My Rheumy has just increased my Mtx from 15mg to 20mg and Folic Acid 5mg from once a week to 5mg every day except Mtx day. The Folic Acid dose does seem to be a massive increase but I will do what I am told. The only problem is that I normally take my Mtx at 7pm and I was only told not to take Folic Acid on that day. I want to get into a routine of taking the Folic Acid in the morning and was not told how long after taking the Mtx I should take the FA. I have read that the FA can effect the action of the Mtx. How does everyone else take their meds and is 5mg of FA daily a safe amount?