How long does Omeprazole (10mg) take to work?

Hi everyone,

I have had severe pains in the centre of my chest, its like a burning sensation. During the first week it got worse because I was on no medication and avoided going to the doctors. I went yesterday morning because it was unbearable. I was prescribed with Omeprazole (10mg) to take once a day an hour before eating. I was wondering how long it takes to work? I had it yesterday, and it calmed down the pain for a while (took the tablet at around 7pm) and I went to sleep at around 11.30pm. I slept throughout the night with few sharp pains here and there but not as severe as they used to be. But then in the morning when I woke up it was very painful again. I know I've only taken it for a day but I was wondering how long it takes to work :)

Also does Ibuprofen work?

19 Replies

  • It should work as needed but you may need a higher dose. The pain in your sternum may not be down to too much stomach acid it may also be another fibro symptom enhancing any problems you have. I take 20mg which I only take because I also take NSAIDs but it had the benefit of stopping the acid reflux and the small gnawing creatures that used to nibble my innards at night ;). I found many years ago I got severe pain in that area which was due to allergy to eggs (although the egg thing resulted in instant, rapid non stop loo breaks too and other things) and intolerance to wheat products especially anything high in fat like pastry and cakes. Generally a diet of exclusion is recommended. Just try cutting something out for 24 hours, then something else, think groups of things like wheat based stuff, then diary, then eggs.

    See how it goes and remember worrying can really kick off tummy problems because it activates the production of stomach acid :) Take heart that it did work partially so its unlikely that there is anything very bad going on. If it gets worse re-visit the doc.

    Take care xx

  • Thank you for your response.

    My doctor said she was going to put me on a lower dose before going up to 20mg.

    I was food poisoned a day before I start suffering from the pain. Can acid reflux follow from food poisoning?

  • Anything can upset the tummy acid levels and if you have had a touch of food poisoning it could do anything. When you say a touch, what do you mean are you sure it was poisoning. Did you tell your doc?

  • I am sure it was food poisoning, it happened the day before I got tummy pains that night after dinner.

    I did tell my doctor, but she didn't pay attention to that, she just said, its not related to the heart and that its acid reflux causing the heartburn, and to avoid, spicy, oily and citric foods.

  • This is a link to what food poisoning actually feels like and does. many people think they have it when it was infact more about eating something that may not have agreed with you.

    That will be why your doc did not pay much attention to it :) I assume you have an appointment so talk it out with the doc and think about what you ate that triggered it rather than food poisoning. As another poster has said, ask doc about ibruprofen before taking, however, all NSAIDs work through the stomach and can increase acid production see overview

    They would not be used to help with stomach pain. Try soluble paracetamol if you don't already take it.

    Really though if you don't get any relief from the pain, which still could be a side affect of what you ate (not poisoning) talk to you doc, write it down before you go in :)

  • Hi Mariya,

    I am sorry to haer that you are suffering from Tummy problems!

    I found this, hopefully It will help :)

    Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

    If you are self-treating with this medication, over-the-counter omeprazole products are used to treat frequent heartburn (occurring 2 or more days a week). Since it may take 1 to 4 days to have full effect, these products do not relieve heartburn right away.

    Speak to your local Pharmacist (re) Ibuprofen to see if this would be suitable to take with any other medication you are currently prescribed. Unfortunately I am not medically qualified to do so.

    Sending you soft and warm hugs,

    Elizabeth :) xx

  • It doesn't take long at all, a few days or so. Give it a week, if no better see your dr again, you may need a stronger dose. I'm on 20mg which I take in the morning, but if I know I'm going out for a meal or a drink I know I have to take 2 tabs. Hope you get relief soon 🐸

  • Thank you, today is my second day only, if gives me interim relief. But I am told it will take longer depending on how bad the inflammation is?

  • Like the others I am on 20mg which I take in the morning it has been great for me after a couple of days I haven't been troubled since. Hope your symptoms improve X

  • Thank you for your response.

    I am going to start taking 20mg too. My doctor said to start in 2 weeks, but 10mg doesn't seem to be making much of a difference.

    When you first started on 20mg, how long did it take to kick in?

  • I'm on Lansaprazole which is a very similar drug. On its lowest dose I didn't find it worked very well but when I took one in the !morning and one at night it soon bcwme effective. My doctor told me change might not be instatenous but might take a few days to help fully. That there has been some improvement gives grounds for optism that if you get the dose right it will really help.

    Cutting out very fatty or spicey food will help and some people find that slightly acid foods like citrus and tomatoes add to the problem.

    Do hope that horrible feeling soon goes and you can get some rest at night. Having another pillow at night might also help.x

  • Hello,

    I understand, It can take some time making sure you have the right dose.

    I've been taking 10mg for 2 days, it hasn't been too effective, it works for a while only.

    I used to have a lot of spicy foods, but have cut it out of my diet completely now.

    Thank you for your advice :)

  • l started with nausea last year and gastrologist diagnosed gastritus, l was already taking cimetidine for acid reflux diagnosed years earlier, which l,d few symptoms with. l was also put on 20mg and it did take over a week to work and settled it 90-percent but l,d also cut out dairy products, use alternatives, milk, cheese, also cut out ready meals, processed, tins, now just plain food, pots products veg chicken fish rice pasta, But as with poster above l have some days where after evening tablet find nausea can come on following mid aft, so on those those days take another, l do know of some on 40mg

    guess it depend on what it takes, if l0 settles probs thats good, but 20m seems more prescribed dose. good luck

  • Thank you for your response.

    The diet really does affect how you feel :)

    My doctor said it was inflammation, and that it may take a while to heal, I was just wondering whether the 10mg would be effective enough.

  • Most patients with gastritus lve read posts from on mbs, seem to be on 20mg, some double that, ironically my gp said to me we can half the dose if it suits, and some days when l,d flare up hours after taking 20mg l,d take another 20mg to settle it, l,d rather not but if needs be. It did take a week for mine to work, but some posters say days, l guess its up to you if your prepared to leave it for a week or more as it is, and then if not settled take another, let gp know you have. If you do decide to take lo twice a day, you could always try to reduce later when it settles. You could also look at gastritus mb, l also look in on one for `patient`, all give advice on diet supplaments

    good luck with what you decide.

  • I would advise against Ibuprofen if you have acid reflux or any stomach problem, I cant take it for that reason xx

  • Hi Mariya1103

    I sincerely hope that you are feeling as well as you possibly can be today? Welcoem to the forum and it is wonderful to make your acquaintance. I have pasted you a link below to our mother site, FMA UK which hosts loads of useful Fibro information:

    I can see that you have been given some really good answers, such as it should start working when you need it too, and that it is not advisable to take Ibuprofen a sit can make the problem worse. I want to genuinely and sincerely wish you all the bets of luck.

    All my hopes and dreams for you


  • You might need a different PPI medication. Omaprazole doesn't work for me, Lansoprazole 30mg did work for a few years, but then I stopped taking it and when I had the burning pain start up in my chest it didn't now I'm on Pantoprazole 40mg in the morning and Ranitidine 300mg in the evening (slightly different acid med) which seems to be doing the job until I see the gastroenterologist in a few weeks.

    Everybody is different and what works for one, might not work for another.

    It should only take a day or so to settle down, so I'd go back to your GP if you are not getting any relief.

  • Yes i agee that omeprazole made me have the dryest TONGUE in the world leading to cracks and bleedin...stoped taking it my tongue back to its powerful tablet...but my reflux has gone since ive been dieting...its a miracle no reflux since dieting does stop it....good luck with them strong glad im off much side effects for mexxx

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