Very low lactate dehydrogenase? 150 while the norm is 310-620 Iu/L Meaning/significance?

[lostcat-]

Hello,

Any of you had a similar issue? The doctor's comment on blood test result just said that it is of no significance. But what does such result actually mean?

Regards

[lou60]

I think you should ask your GP exactly what this means, it really isn't good enough that your concern is brushed aside. I do hope you get answers soon. Lou x

[TheAuthor]

Hi lostcat-

I am so sorry to read that you may have Lactate dehydrogenase deficiency, and I sincerely hope that you can find some resolution to this issue.

Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells. However, there are two main types of Lactate dehydrogenase deficiency. So, I agree completely with lou60, it would probably be more beneficial to discuss this with your GP? I would ask them for a full and comprehensive explanation.

I want to genuinely wish you all the best of luck.

All my hopes and dreams for you

Ken

[Bug1966 in reply to TheAuthor]

My LD is 143 and Dr not concerned. I am and that it could me Rhabdomyolosis.... Any thoughts??? Already hypogammagobulemia, AS, Fibro, osteoarthritis, neuropathy, and much more

[TheAuthor in reply to Bug1966]

Hi Bug1966

The *WebMD website that belongs to *Boots Pharmacy says:

*Results. Lactic acid dehydrogenase (LDH) is an enzyme that helps produce energy. Results may vary widely from lab to lab. Normal LDH levels range from 140 units per liter (U/L) to 280 U/L or 2.34 mkat/L to 4.68 mkat/L.

However, I would be tempted to seek a second opinion on this as these levels sound quite low form what I have read. I want to sincerely wish you all the best of luck and please take care of yourself my friend.

All my hopes and dreams for you

Ken

[phlebo123]

Hi lost cat

Low levels of lactate dehydrogenase can be caused by a genetic condition which causes fatigue and muscle aches. (That sounds very familiar!!) As Ken says it is an enzyme that helps produce energy in our cells... so how can that be considered not important?

I think you should pursue the matter further with your doctor. Ask him why this is not significant?

Hope you get some answers, xx

[rosie97]

Hi just wanted to say I hope you find an answer, I have the opposite problem. My Lactate dehydrogenase is elevated and keeps rising. But the Doctors just say don't worry about it. Good luck with getting an answer.

[lostcat-]

Thank you for responses and explanations, everyone, really appreciate them.

I will be seeing another doctor in a week, will see what he says, and post an update after the appointment.

[lostcat-]

Update: another doctor said the same thing, pretty much dismissed it. I don't get it, if 150 isn't a deficiency then I don't know what is.....

[Mdaisy]

Hello Lostcat,

I looked at the NHS choices to try to find information for you & it links to this site which talks about the lab test results;

labtestsonline.org.uk/under...

It says the following Low and normal levels of LDH do not usually indicate a problem. Low levels are sometimes seen when a patient ingests large amounts of ascorbic acid (vitamin C)

However, when my B12 was borderline low (240) the GP said it was not to be treated until under 200 after speaking with Dr Choy at Guys Hospital, London he requested that I should receive treatment.

Are you symptomatic ? I suppose you can't tell as with Fibro the symptoms are similar to low LDH (in some cases) so I've just read. Do you feel worse ?

I have never come across this before, if I find anything of interest I'll let you know.

Best Wishes

Emma

FibroAction Administrator

[lostcat- in reply to Mdaisy]

Hello

Thank you for taking your time to look this up and reply.

Perhaps I will wait a few months and repeat the test, see if it stayed the same or decreased.

I've been suffering from EXTREME tiredness/weakness/muscle aches and lethargy, it has gotten worse last year. I thought that a more comprehensive blood test may show something and this thing came up. I just find it difficult to comprehend how there is no one conclusive test that would determine what exactly is wrong. We can only hope that there will be one in the future!

All the best

[CindyD]

Lostcat have you received any more information? I have been told my lactate dehydrogenase is low. Do you have a rash anywhere?

[lostcat- in reply to CindyD]

Sorry for late response... But no, no new info on it... No rash but I've very sensitive skin.

[sm41478]

I like you have been recently diagnosed with  low levels of LDH. I've been feeling like I have weights on my arms and legs and feel like I'm a walking zombie. I wake up tired and go to bed tired. It's even hard for me to go to work. My Doctor said that they usually do not treat low LD. My number was lower than yours at 83. I also have higher levels of blood sugar, but don't know if it's related. If anyone could shed light on this it would be appreciated as it's hard to find anything about low LD on the net.

[lostcat- in reply to sm41478]

That's really low. I'm not sure why but there's not much on this issue on the web. And it seems like the doctors simply don't know much about it either?

[Hidden in reply to sm41478]

Hi, I hope you are feeling a little bit better.

OMG, I know what you mean when you say your arms are heavy...., I too feel like a zombie, I keep saying that to raise my arms is like I'm raising 100lbs on each it's unbelievable, in the morning is the worse, I feel like I'm made of iron and my bed is magnetic, I'm going to tell what I've learned in the last 3 years of this ordeal.

I've been in 3 doctors and now I have one that I really like, she listens to me, I complained of feeling lethargic then she performed a stress test to check my heart to see if it was the cause of the extremely fatigue NO, then I had a very detailed allergy test NO, then I was diagnosed as insulin resistance, as I used to go 6 hours without eating, then she said that my thyroid wasn't working so there goes thyroid medicine and I started feeling little better and went back to my gym workout but after 4 months the stupid tiredness came back and the point that I thought I was going to pass out on treadmill, so I went bk to doctor and she put me on an anti depressant med, WHATEVERRRRR, of course the medicine helped a little giving me energy but didn't last long, so right now I've stopped with ALL the medicines by myself and I just did a 7 vials of blood work and the FIVE pages just came back, my LDH is 91, my vit.D, iron, iron saturation, calcium, phosphorous are LOW, I'm still going to the doctor but I'm pretty sure that our body works as a team, doesn't exist just one cure, I need to keep meditating to keep stress level low, eat healthier because when we eat junk our body get inflamed and every part of it starts to complain but I'm anemic, the iron plays a very important role on bringing oxygen to the cell, yesterday I started with iron and vit.C together to help absorption the after 3 hours I took calcium with D3, im don't like vegetables too much but will start eating more, I'm lowering intake of lactose, and will try to lower gluten,I hope soon I will be able to go back to gym because it's 50% of the situation solved, after exercising I feel awesome, so keep positivity high and don't expect the doctor will save all your problems because they won't unfortunately, we need to learn that is in our hands to be health, I hope we will get the strength to fight the feeling, IM TIRED OF FEELING TIRED, my husband and my sister are tired of listening to my complaints but how in the world a person can face everything if can even walk normally, last week I've took 1/4 of caffeine pill to help me keep moving cause the world doesn't stop.... Best wishes.🌺

[sm41478 in reply to Hidden]

Thank you for your reply. I've done some reading and research. I would suggest you get off the vitamin C as it lowers LD levels and can be worse.

[Elannon in reply to sm41478]

Do you know any more info than posted here? I have been wondering why I feel as though I can't get enough sleep and feel so heavy. Then I was looking over my labs and saw my LDH level is only 69. I don't see my doctor until next week and I want to be prepared to speak with him.

[Gettingold51 in reply to Hidden]

Hello Bruna2016

"an anti depressant med, WHATEVERRRRR" I laughed at that... Up North Doctors put everybody on Anti depressants... for anything..

I have a 75 LDH count as of Two years now.

been trying to figure it out, with so help from doctors. but they mostly have never heard of it.

I have been active all my life and now it just hurts.. 12 hours of sleep a night is normal. I ripped my Bicep 4 cm, 2 years ago pulling myself out of the water after scuba diving. something I do maybe 20 or 30 times a month now I live on my Yacht in the Caribbean. so Depressed...?. NOT. lol.

I have tried a lot of different treatments like Magnesium... I eat healthy foods, but have changed around diet, but no change to feeling better.

Right now my left shoulder has been in pain for 6 months.. pulled it or something.

the gym is probably not a good Idea for you. very light work if you do.

be careful not to rip your mussels.

I find if I am lifting things on the boats, 50 lbs or more, I will hurt for days after. then a couple of days of major rest and I feel better.. i don't lift anything over 75 lbs anymore to be safe. 10 years ago I could lift 300 plus pounds. so it is not just getting old, it is the LDH.

I have asked my Family that is still alive to check their LDH levels to see if it is inherited. no results back yet.

Hope you feel better. don't complain to your loved ones. suffer in silents, and feel lucky you are alive. I bought my boat and went sailing full time after my 3rd sister of 8 died on my 49th Birthday. she was 5 years younger than me. Cancer.

Hope this helps in some way.

All the best, Marko.

[sm41478]

Bruna, hey I'm just wondering if any of your Doctors sent you to a dietician as some of the things I'm reading about low LD says that diet helps? Just curious as to what they might have said about this?

[shance]

Hi LC - I was so pleased to find your post and this forum, because there seems to be very little on lactate hydrogenase deficiency. I too am low in LDH and additionally I'm experiencing (and have experienced for years) very low energy and at times motivation. The body feels heavy like others have mentioned. I'm a personal Trainer so it is equally problematic in that regard as well. If there is any silver lining, it would be the indication that low LDH could be at the core for many with Chronic Fatigue. I find it interesting that Doctors seem to minimize this issue. Sad really. So far I haven't found any information and/or enzymatic supplementation that helps but am certainly on the search and would welcome any and all feedback others may have as well. All the best, Connie (aka shance )

[lostcat- in reply to shance]

Hi

Sorry to hear about this!

Yeah, in most sources, it says that low levels of it shouldn't be a problem. Apparently, too much vitamin c can cause it but that's not the problem in my case.

However, I found another source (not in English) saying that there are two possible genetic mutations causing low levels of LDH, not just one - someone already mentioned one of them on here. People suffering from the first one suffer from tiredness and muscle pain. The second mutation usually does not give any symptoms.

Here's some more info from an english site

What is lactate dehydrogenase deficiency (glycogenosis type 11)?

This disease is a metabolic muscle disorder, a group of diseases that interferes with the processing of food (in this case, carbohydrates) for energy production.

What are the symptoms of lactate dehydrogenase deficiency?

Lactate dehydrogenase deficiency results in exercise intolerance and episodes of myoglobinuria (acute muscle breakdown leading to rust-colored urine). A skin rash is common, probably because skin cells need lactate dehydrogenase.

What causes lactate dehydrogenase deficiency?

The disease is caused by a genetic defect in the lactate dehydrogenase enzyme, which normally recycles byproducts of carbohydrate metabolism.

What is the progression of lactate dehydrogenase deficiency?

The condition has its onset in early adulthood and does not progress.

I do exercise but it's a massive struggle even though I used to be a total gym bunny as a teen. However, I don't have a rust-coloured urine. Do you? Lol sorry if its too personal, just trying to see if we have anything in common. When did yours start? I've only had that blood test year ago but I'd say that I started getting the symptoms in early adulthood. Not sure if they are getting worse or are standstill.

[Gettingold51]

Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells.

There are two types of this condition: lactate dehydrogenase-A deficiency (sometimes called glycogen storage disease XI) and lactate dehydrogenase-B deficiency.

People with lactate dehydrogenase-A deficiency experience fatigue, muscle pain, and cramps during exercise (exercise intolerance). In some people with lactate dehydrogenase-A deficiency, high-intensity exercise or other strenuous activity leads to the breakdown of muscle tissue (rhabdomyolysis). The destruction of muscle tissue releases a protein called myoglobin, which is processed by the kidneys and released in the urine (myoglobinuria). Myoglobin causes the urine to be red or brown. This protein can also damage the kidneys, in some cases leading to life-threatening kidney failure. Some people with lactate dehydrogenase-A deficiency develop skin rashes. The severity of the signs and symptoms among individuals with lactate dehydrogenase-A deficiency varies greatly.

People with lactate dehydrogenase-B deficiency typically do not have any signs or symptoms of the condition. They do not have difficulty with physical activity or any specific physical features related to the condition. Affected individuals are usually discovered only when routine blood tests reveal reduced lactate dehydrogenase activity.

Hello Everyone.

About A year ago I ripped my Right bicep 4 cm, doing nothing more than climbing out of the water after scuba diving into my tender. I am a Dive Master and lift 60 lbs tanks daily and am in good shape. So this was very shocking to me that I did this so easily ...

I had blood tests done just after that and the only thing abnormal was my LDH, Low! at 150.

My GP said don't worry about it.... but I did because I could feel something had changed in my body. I have had many different experiences in life and lived all over the world and at 51 years old, been in ICU twice and so on, I kinda know my body well. I eat a well balanced diet and always have, and I Exercise regularly. always have.

So I took a second blood test about one month or so later just to see if the LDH read of 150 had changed, It Had not.

now refereed to specialist and they are still testing.... with no luck

I always feel tied. I am semi retired and live mostly on my boat in the Caribbean, so I can sleep more than normal.... but it sucks sleeping 12-14 hours a day....

I have to be careful about how I use my body for lifting and moving weights..

I was getting on my bicycle about a month ago to run my dog for a few miles and slipped off the pedal, saved my self with my arms on the handle bars..... now I have damaged my right shoulder. It is taking much longer than normal for the mussel tissue to recover as well.

I have also as of late started to have a lot of pain in random places.

If anyone has any information on what will help with Low LDH, I would welcome any thing to help greatly.

Thank You

[lostcat- in reply to Gettingold51]

Hi

I don't really have much to contribute anymore but I also need a lot more sleep than an average person. I can't function on 8 hours of sleep, even though I used to be fine in my teens (im in my 20s now)

Would be good to know if others with this condition also need more sleep than average, I'm curious to know if this could also be a symptom.

[Gettingold51 in reply to lostcat-]

12-14 hours a day for me of sleep

[lostcat- in reply to Gettingold51]

mines at least 11. it sucks, seems like a waste of life : (

[Gettingold51 in reply to lostcat-]

Yes. "But this is life" as my Great friend from South America says in had times and she has seen very hard times in life. I have learn to take 2 hour naps at noon as the Spanish normally do.

One Important thing I have discovered is Aspiren helps with the pain the best. I have test many different types and all others have no affect on the pain, ecept the Aspiren.

I have read that vitamin C, aspirin and alcohol can all raise the readings of LDH in the blood test....

[rustyhead in reply to Gettingold51]

Hi,

try to eat cottage cheese 2-3 times a day for at least 2 weeks. Please let us know if it helps.

[BrianM1977]

I'm being tested for PV and just had this test done my results were very low it was 124 waiting for more test results

[Bug1966]

My LD is 143 and the doctor is not concerned and every one of my IgG and all subtypes are low as well which the oncologist referred me to immunologist now and got diagnosis of hypogammagobulemia for IgG but concerned about LD because it could be Rhabdomyolosis and I already have AS which is autoimmune disorder, severe Fibro, osteoarthritis entire spine, both clavicle and shoulders, right hip, left knee, and hands, neuropathy and tons more. Also lots of muscle wasting and continue to lose weight. Ugh

[Vgustafson95]

My LDH level is 104 on a normal scale of 140-271 what does that mean? A deficiency I guess but should I be concerned?

[kjackson]

Really pleased to find this discussion. I have been getting blood tests done privately every 6 to 12 months for the last few years and my ldh is always low, between 121 and 138, on a scale where the normal range starts at 310. I had some genetic testing done privately a few years ago, and looking at my results from that I have homozygous mutations on three LDHA snps. My symptoms are exhaustion and big dips in energy particularly after meals if I do not eat little and often. I was diagnosed with B12 deficiency 4 years ago, and my health has improved since then with frequent B12 injections and lots of other supplements, but I still struggle with tiredness. That is why I have started looking into other reasons. I cannot find any research into treatments for LDHA deficiency, it seems to be a condition where we have to find our own coping mechanisms. I am not confident that I would be able to find a doctor or specialist who knows about this.

[sm41478]

Hello again everyone! It's been a while since I've been on here. I'd like to share with all of you my medical journey over the past two years in hopes that it may help others like me. First, let me start off by stating that I am not a Doctor and this is not meant to be medical advice. I like many of you was feeling zombish, lethargic, and weighted down. It came to a head two years ago when I was at work and couldn't remember how to do something I had been doing my entire life. That was when I had to go to the Doctor as the incident scared me. Just so you know my stats, at the time I was 37 years old and 115lbs (very slim build) male. At the first appointment my blood sugar was checked along with cholesterol and urine. Everything was normal except my blood sugar which was a little high. At that time I was diagnosed with pre diabetes and was put on a diet that I took seriously. Still not feeling well, I went back a few weeks later and more blood tests were ordered to rule out thyroid, anemia, and others. All came back normal. A few more blood tests revealed low LDH which was 83 and a vitamin D deficiency. I was put on 1,000iu daily of a Vitamin D supplement and was told to stop taking C. This increased my D levels to normal and also helped with the low LDH which is also now in a barely normal range. Feeling a little better I decided to give it a bit to see if I would start to feel better. It was short lived and I was back at the Doctor's office. Many more blood tests and no abnormal results made all of the doctors put all the emphasis on my pre diabetes diagnosis. I doubled down on the diet and asked to meet with a dietician. Because this is getting too long, I'm skipping now to present day. About a month ago I went to the Doctor, but this time I wrote down a complete list of all of my symptoms no matter how small or if I felt they applied. I will put a list of my symptoms at the end of this so that others on here can compare to see if any of them sound familiar. I didn't even know some of my symptoms were symptoms. Long story short, after my Doctor got through half of the list she said you have fibro. Being a male I didn't think of that as a diagnosis because I like others thought it was a woman's disease. A tender point test confirmed the diagnosis as I had 16 of the 18 sensitive areas when only 11 are needed for a positive diagnosis. My Doctor prescribed Cymbalta, but after much research I decided not to take it as I didn't like the side effect list and was not keen on changing brain chemistry in the way that line of drugs do. Since my main complaint was weakness and concentration due to fibro fog which I didn't even know was a thing, I decided to look into ADD medications. I scheduled a phone conference with my Doctor to discuss taking a small does of Adderall. This drug at only 5 milligrams per day have been a life changer. I am my old self and have the energy for the first time in years to do the things I need to and like to do. It has also helped with the weighted down feeling and the pain. I can only hope that you all also have the results and diagnosis that you all need and deserve. God Bless and take care. I hope this helped others in similar situations. Please see the next post for a list of symptoms I promised.

[sm41478]

Okay, so If you've read my last post I promised that I would share a list of my symptoms with you in case any of you are dealing with the same issues. Again, my diagnosis was pre diabetes and Fibromyalgia. Here's the list.

Constant Exhaustion, Muscle fatigue and widespread pain, muscle twitches, heat intolerance, hot flashes with a swaying feeling, hands turn white in cold water, cold hands and feet, sinusitis and laryngitis, thick mucus, skin sensitivity, stiff in the early morning and late night, brain for when tired, shaky and weak, anxiety, burning muscles, headaches associated with strong smells or noise

So that's it, I know it's a long list, but it was the key to the diagnosis. My only suggestion to all of you is to write down all of your symptoms because you never know what might be the key to figuring out what might be ailing you especially in a disease like mine where it's a diagnosis of exclusion. If any of you have any follow up questions for me please feel free to write back.

[SusaninNC]

Hi everyone, I'm another one that has realized that I also have a low LDH at 87 in 2015 and have been complaining to different Physicians of my fatigue, sore muscles, brain fog, having to rest more than is normal, sensitive to heat, and more. I just started with a new Physician and ask her to check my LDH after I found this site and it is now 86. I go tomorrow to see what she recommends I do to fix it. I'm wondering if it could have anything to do with being acidic?

[HardcasB]

So I just came across this today and like many of you I have the same symptoms. I was diagnosed with LDH in February my shortened story is this: For the past ten years my visits to the dr office and hospitals have been something of a novel. I have been hospitalized for kidney failure, have had exploratory surgeries, been poked and prodded like an experiment, been told it's just in my head and put on anxiety and antidepressants. It wasn't until 4 years ago my GP finally realized something was wrong and I started to see my fantastic hematologist. I have been seeing him for the past 3 years. At first he wanted to rule out anything life threatening as it wasn't a clear prognosis. Through extensive blood work this is what he found with me: red blood cells have a shorter lifespan than normal (they are also not the right shape) which means my body is producing more red blood cells than it should causing the white blood cells to act like there is an infection (which makes me sick a lot) and my platelet count is always low. My Specialist had ruled out life threatening diseases and has diagnosed me with the lactate dehydrogenase deficiency which he says effects less than one in a million (so could explain lack of knowledge and resources).

I have been told that through taking vitamin B50 and folic acid every day it should help. So folic acid maybe something to try. I continue to see my specialist every 4-6 months but am still in a lot of pain as I'm an active person who lives for hiking.

Hope this post helps some of you. I was having a really tough day today because as my friend put it "it has to be tough living with an invisible illness" so was happy to stumble upon this thread and gave me some ideas to try myself

[deal15]

Hi all. So I am wondering has anyone recieved treatments for low LDH? Or found a way to increase your levels. I just found out my level is 60 My dr was very perplexed said they never have seen before and she is doing some research to see what kind of specialist I should see. Any info is helpful. Thanks