In May 2013 I asked my GP to put me on Duloxetine (alongside my 20mg Amitriptyline), as she refused to send me to pain clinic. However after an initial 3 week "rush" I slumped into really bad fatigue. After 6 months I moved over to Fluoxetine, as I suspected the adrenalin levels in my body had been upset by the duloxetine. After a short remission, it started up again, so I reckoned that because the Amitriptyline has the same mechanism - and I have been on it over 11 years - I would try coming off that slowly. I took my last one last week, and I still feel rough.
I am going through the menopause, but this is extremely bad. My sleep is being affected and I am getting really hot spells at work, where I have to stop and sit down and get a cold drink. I work at a hospital, and have had numerous staff tell me I look rough and shouldn't be that bad just coming off 20mg dose.
Has anyone else had this problem which could have been set off by Duloxetine? Can it cause adrenal fatigue, and how long do you think it will take before I know the Amitripyline will be out of my system totally?
I am going through getting a referral to the sleep clinic - hence another reason I am off the Ami, as I was told previously it would be necessary before they could get an accurate test, but never dared come off them before.