implantation failure!!! What else can I do? Prp rejuvenation? Any advice please help

[R1985]

Hi all you beautiful warriors. After 3 unsuccessful ivf rounds with my own eggs. I moved to donor eggs in Spain. I now have had two failed DE transfers and wanting to go for one last round. I just had a hysteroscopy suggested by my doctor and they found a small polyp and removed it. No endrometitis found or anything else with my endometrium. I have had the Ermap done biopsy taken before my second transfer and they didn’t find any nk cells nothing other that I was pre receptive at days 5.5. My endometrium lining was fine for transfer both times. For the third transfer the doctor has suggested prp rejuvenation along with antibiotics and probiotics. Anyone have experience with prp? Is it worth it? Anything I can do? Any advice would really help

[JA-fnuk Partner Nurse Fertility Network UK]

Just wanted to wish you luck with your treatment and hope you get some replies to your post . Remember to look after yourself

Thinking of you

Janet-Partner

[R1985 in reply to JA-fnuk]

Many thanks for the kind words

[ET54AA]

I have failed two IVFs and my AMH was 0.9. Now my AMH has dropped to 0.43 and I asked my doctor to do ovarian rejuvenation. He said yes and I did it yesterday. I did laparoscopic ovarian prp. I am recovering from the intervention. After two weeks I will test to see if that has made any difference.

[R1985 in reply to ET54AA]

Hi many thanks for your reply but since I’m using DE my doctor recommended endometrium rejuvenation. Did you do the prp in the UK or abroad?

[laloles]

I don’t understand why would you do rejuvenation if you are using a donor? I did it to use my own eggs last year and I didn’t get any positive results.

[ET54AA in reply to laloles]

What do you mean no positive results? PrP didn't work? What is your age and Amh?

[R1985 in reply to laloles]

Hi my doctor is suggesting endometrium rejuvenation as I have had failed IVFs using DE. It’s quite a costly treatment given the doctor said I need to get three prp’s and stay in Spain for a week. I was wondering whether it’s worth it and what else I could do instead.

[Doodlebug23 in reply to R1985]

After 3 failed transfers and a chemical my clinic have suggested an HCG wash. I found this:

“In order to create a “sticky” uterus, some women are recommended to have an HCG wash just prior to embryo transfer. It is believed to improve IVF results. In IVF, HCG is absent in the uterus because the embryos are in a dish, not in the fallopian tube triggering HCG production. There is evidence placing HCG into the endometrium improves the response of the endometrium to the embryo so it is “ready” at the time of transfer. This is a uterine infusion.”

I have also read some studies that had really positive results. Not sure of the costs as it’s included in my programme x

[R1985 in reply to Doodlebug23]

Thank you so much for this. I’ll ask my doctor if they can include this. Have you done this HCG wash yet? Is it painful?

[Doodlebug23 in reply to R1985]

No it will be at my next transfer. I haven’t really had much info from my clinic but I found this repromed.co.nz/wp-content/u...

[R1985 in reply to Doodlebug23]

Thanks. Are you doing ivf abroad?

[Doodlebug23 in reply to R1985]

Yes in Spain. The only info I could find on my clinics website was to do with their research on it though not the actual procedure so I googled and found that info

[CyclingAddict]

Sorry to hear that. I'm not expert but I can offer you advice based on my own experience. So I've had 4 failed transfers with good quality embryos (on the NHS) and 1 miscarriage with a poor/average quality embryo (at a private clinic). One thing that the private clinic gave me that I didn't get on the NHS is steroids. My consultant carried out loads of blood tests and found out I had hashimotos (unbeknownst to me as I have no symptoms and it hasn't developed into full blown hashimotos yet). So, because I found out I had an autoimmune disorder, my consultant wanted to temporarily reduce my immune function. He also advised against antibiotics (which I'd been given on the NHS) because they negatively affect your gut biome, but he did suggest taking vaginal probiotics to improve the bacteria culture in my womb. I also had tests to see exactly have many hours I should be on progesterone before transfer. All this seemed to help as it was the first time I even got pregnant, and it was with a 3BC embryo. I've just gone through another cycle and added in another step, PTG-a testing, because of the 4 failed transfers and 1 miscarriage. Hope this helps!

[R1985 in reply to CyclingAddict]

Many thanks for your detailed reply. Sorry for what you have gone through. My consultant also recommended antibiotics with prebiotics. How were you diagnosed with Hashimoto?

[CyclingAddict in reply to R1985]

No worries! With the hashimoto's testing they have to do a blood test to measure your antibodies to determine whether antibodies are attacking your thyroid. Usually to check a for a thyroid condition they will measure your hormone levels to see if they are in normal ranges, but this can be ineffective if you have normal hormone levels (like I do) - that's why they need to measure the antibodies specifically. Hashimoto's unfortunately can lead to miscarriage and birth defects if left untreated, and it is fairly common (one in eight women will develop a thyroid condition in their lives). Worth asking your doctor if you do have concerns about your immune system, as it's only a little blood test. Good luck!

[Yellow83]

Hey, I’ve had the prp rejuvination for your endometrium lining, I think that’s the one you mean not the ovariun one. I’m also using DE in Spain. I don’t have a success story unfortunately but it definitely helped my lining as I’d had endometritis and various adhesions so it helped with the healing from that. It is expensive though. Have they given you a reason to try it or just because it’s something you haven’t tried yet? X

[R1985 in reply to Yellow83]

Yes that’s correct it’s endometrium lining. No they haven’t given me any reason other than let’s try something different but me and my husband calculated that it will be quite costly especially if there aren’t many successful rates with it? Also I only found one place in the UK that does it for £800 per session and I’ve been told to get three sessions. How did they find endometritis? I just had a laparoscopy and this was not found.

[Yellow83 in reply to R1985]

I had a hysteroscopy at the start of the PRP process and there was some indication of it then. So I took some antibiotics which I’m assuming helps too.

When I had it they took loads of blood one day then, the following day I had a hysteroscopy where they injected some PRP stuff too I think. Then about a week later I think I had three other sessions every other day then the transfer some days after that…I think that’s how it went! They’ve advised I do it again for my next round too, lots to think about.

You are right though it is super costly everything just adds up 🤪

[Seren0119]

I would highly recommend HCG flush and steroids before trying more expensive treatments x

[R1985 in reply to Seren0119]

Many thanks I checked my clinic and they don’t offer HCG flush they said they offer the ovitrelle injections. I don’t understand why and I’m lost.

[Seren0119 in reply to R1985]

Perhaps change clinic with more advanced options? X

[Chel91]

I had recurrent implantation failure. While I was using my OE, I was only in my 20s so I knew something wasn't adding up. In the end I had a laparoscopy surgery with a specialist and they found and removed endometriosis. I also did Reproductive immunology with a specialist (steroids, blood thinners, immune drugs). I believe these two things are much more common to try before prp. I would personally tell any of my friends with symptoms of endo to strongly consider the surgery, it was life changing for me and a real eye opener as to why symptoms had been ignored since childhood. Check out Nancy's Nook FB page for info and specially trained surgeons as this is very important when considering it, it can't be a novice (that's where I found mine). All the best x

[R1985 in reply to Chel91]

Many thanks for the detailed response. I did have mild endo removed 4 years ago but still have somewhat painful periods and heavy bleeding. Can I check who was your surgeon and if different the reproductive immunology specialist?

[Chel91 in reply to R1985]

Was the endo removed via excision or ablation? Supposedly it does make a difference. There is a lot of new info out there. Definitely check out Nancy's Nook. They have a lot of info and a surgeon list in their file section on their FB page. I think it's a word document you can download. Reproductive immunologists are different, there aren't many of them. I live abroad so mine is abroad, but I think there might be one in Spain that I've heard of if you are getting treatment there. It's a female doctor that I've heard ladies have used (but I have no experience of her), but we can't share names on here. Feel free to PM me, or maybe make a post asking people to PM you names / recommendations xx

[R1985 in reply to Chel91]

I think it was removed via excision. Thanks I will look at that page and also pm you.