Help, losing hope, What next? 2nd IVF failure negative 6dp5dt

[Habibi87]

I am loosing all hope and really don’t know what to do next.

We had a second FET last Sunday with a single PGS tested hatching embryo and the first response test today is absolutely negative. With our first IVF, positive started to show 5dp5dt but it ended in a chemical. As I always have some fluids in the womb at the beginning of the cycle (they disappear around ovulation time) before this second FET we did a hysteroscopy which showed everything was normal, absolutely nothing found. In this FET fluid disappeared from around day 13 and there were no fluids on transfer day. The doctor also asked us to do thrombophilia screening which again was normal and NK cells tests for both uterus and blood. NK cells in the womb were normal but the blood ones were slightly raised so we did intralipids a few days before the transfer. Because of the chemical pregnancy with the previous cycle, the doctor ruled out the need for ERA as apparently the chemical showed that the embryo transfer timings are right. This was a natural FET supported with cyclogest and also blood thinners injections (just in case said the doctor). The endometrium was over 10mm. On the day after transfer my progesterone was low (42) so they added lubion twice a day and when they checked yesterday (day 5) progesterone was at 284. I feel like there is nothing else left to do and that we have already no hope left at the age of 35. I have low AMH but we are doing IVF because of MFI. I only got pregnant naturally once with twins but it ended in a missed miscarriage at around 8 weeks. We still have 4 pgs tested embryos (day 5 and day 6), but I really don’t know what could be different if we tried FET again. I have bombarded my body with medicines and tests and spent so much money but nothing works. Am I missing anything ?

[IVFat40]

Hello lovely, I'm so sorry, negatives are so incredibly painful, just devastating. At the risk of falling in to the super annoying 'just keep trying' camp, it does sound like your next embryos will have a really good chance. I expect you know all this already, but my understanding is that even with PGS tested embryos they have about a 60-70% chance of implanting and continuing, so at this stage it could really just be horrible luck that these two haven't made it. Which doesn't make your pain any less right now, and I'm sorry if it's insensitive of me to suggest just carrying on. My circumstances are very different (I started at 40 and my embryos weren't tested), but I had success with my 8th embryo transferred (not that I think for a minute it will take you that long!). The only thing I did wonder is whether your Dr would prescribe steroids for the NK cells? Steroids (Prednisolone 20mg) were a massive game changer for me (I have high uterine nk cells). I also had the endometrial scratch on my successful transfer, but I think the evidence for that is mixed (I feel it was the steroids that really made the difference). With everything you've already done and checked I'm pretty certain you'll already have thought of this but if not, have you had your vitamin D levels checked?

[Habibi87 in reply to IVFat40]

Thank you so much for sharing your story. I have emailed the doctor to ask for a consultation and I’ll ask about the prednisolone. I was tested for vitamin D a few months ago and it was in the normal range, I have also been taking 2000 iu of vitamin D for many months x

[sun-and-rain]

I really understand that you feel low, but 6dpt is really early to expect any positive result. Even uf it started to show early last time, as it ended up as a chemical you couldn't say that that's was positive to get that positive test that early. Hang on till OTD. Only then you'll know for sure! For me I had the faintest line at 8dp5ot (I didn't test earlier, but the line was so faint I doubt I'd get a positive result any earlier either), and I know people with successful pregnancies have had negative test clise up to OTD. So don't lose hope yet ❤

And also, you can't give up after two transfers! Well, of course you could, but I'm sure you'll regret it knowing you have your embies still on ice. I'd give thise embies a try, and if you still don't succeed, well, then you'll have to decide if that was it or if you'll head for a new collection. But that's not now. Don't lose hope, and give your little ones a try. That's my advice ❤

[Hidden]

I think you are too early to write off this round! But also I think sometimes you have to accept it’s a numbers game and there’s luck in there two. Two transfers isn’t a lot in the scheme of IVf and whilst I don’t mean it’s not difficult, if this round doesn’t work it doesn’t mean the next one won’t. I know people who have taken 8 rounds to just get a positive. I know someone who had their two children on their last two transfers number 7 and 8 with their absolute worst embryos. Try to think positive about this round but if it doesn’t work out you should keep on keeping on and you should get there. Good luck x

[MakingbabyN]

Hey. Sorry to read. Have you considered a medicated FET? I had 2 unsuccessful natural FETs, then a successful fresh (which ended in a late loss 💔) then a successful medicated FET (currently 15 weeks). I figured after the 2 natural FET fails but fresh success that maybe my body responded better when medication was controlling it. It also took out any element of doubt, I knew my lining was nice and thick and that medication would help to maintain it. Don’t give up, hopefully all of this stress and pain will be worth it for all of us soon and we will look back and be glad that we struggled through 🙏🏻🙏🏻 Xxx

[Twiglet2]

So sorry about your negative 😢 In iVF (just like with trying naturally) there is still a game of chance we can do everything ‘perfectly’ but the embryo just doesn’t stick unfortunately, and it can be nothing that you or the doctors could have done differently that would have affected the outcome. It does sound like you’ve found the right process for you and have some lovely embryos waiting to go so fingers crossed one of those will be the ‘one’. It was embryo number 4 (transfer number 3) that worked for us and actually that’s pretty lucky to get that result for our first round and 3rd transfer as it can take others quite a bit longer (it’s such a numbers game 😢). There is of course the chance that this round will turn around for you 🤞🏽 Xx

[Babydustforall]

Hi! I’m so sorry for your trouble. It is all devastating and sooo hard. The good news is that you have more embryos. That is so much of the battle. I tried a few different things after multiple losses. Ultimately, I was also on a blood thinner and prednisone, which was recommended here. I also was on claritin and pepcid, estrogen and progesterone of course. I think the nonhormone-meds were to suppress my immune system. I would try it all!! I stayed on lovenox (blood thinner) for the entire pregnancy. I wish you so much love and luck and am here is you have any questions or to help in any way at all!