I have recently gone through the implantion clinic with my IVF clinic, and they found a number of changes I need to make in my treatment plan.
I have high NK cells, they are prescribing prednisolone 20mg for for my NK cells.
Also clexane injections.
I asked my clinic about having intralipid infusions but they are saying they aren't currently offering this at the moment (not sure if it's because of covid) and said it's not part of my treatment plan.
A friend of mine had nk cells, she was treated with prednisolone and intrapalids, and shortly after had a successful pregnancy and now has a healthy baby girl.
I've seen a lot of women having intralipid infusions as well as taking steroids to help deactivate their NK cells.
I have found a clinic close to me that will offer intrapalid infusions, and are saying to book this in for 4/7 days before embryo transfer, after a positive pregnancy test and after a heartbeat scan.
What would you ladies recommend? I'm considering having it, I can't see if causing any harm. As it does the same thing as steroids as they both surpress your immune system and deactivate NK cells.
I have had 3 failed transfers. And I want to do everything I can for this next transfer to work.
Anyone who has taken steroids and intrapalids, please can you reach out
Or anyone is currently about to start treatment and is about to take both, please let me know your thoughts.
(Sorry long message, but I want to make sure I'm doing the right thing)
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I've had cycles where I did intralipids & steroid which failed, chemical & miscarried. In our most recent I took steroids only & we had twins. I decided against intralipids as I'm not sure I really believed they were beneficial. I do think steriods do their thing though. I also had an ERA done as my implantation window was my biggest problem along with low progesterone and wish we had discovered this sooner. Good luck with what you decide.xx
No I hadnt had my ERA done at that point but we had started trying starting progesterone earlier and I got a couple of BFP but that didnt stick. Turned out I need a full 24 hours more of progesterone and a higher dose. Great news that you've got this info already. I started on 20mg of prednisolone but dropped to 10mg daily as per my clinics protocol. I always think this I'd about having no regrets so if you want intralipids then go for it! The timings they have given you sound about the same as what mine recommended if I chose to have them.xx
I've read online, how important timing and progesterone levels are. I'm glad it worked for you 😊 hopefully with my new timing / change in progesterone. It will work next time for me How much progesterone were you given for your successful transfer, were you on both injections and pessaries?
I'll have a think about intralipids. I can't see it causing any harm as intralipids and steroids do the same thing (deactivate NK cells)
Do you think it was the change in timing / progesterone that was the main reason is worked for you ?
I had cyclogest 2x400mg pessaries an 2 lubion per day. Yes, I definitely feel the timing and the increase in meds did it for us although we had good embryos too obviously. I do think there is an element of luck in there too!! All the best.xx
Aww amazing. I've been following your journey, it gives me hope.I'm taking x4 400mg cyclogest a day and 1 lubion a day. I am going to book a blood test before transfer to ensure my levels are fine, Hopefully should all be good 🤞
We are transferring 2 embryos this time aswell, 2 day 5 blastocysts both graded 5AB
I feel this is the closest I have been. Im really praying it works next time 🙏
Yeah I have decided I am going go for it, there's a clinic in Birmingham thats not to far and have booked to have it done there. I want to give myself the best possible chance🤞
Aww best of luck! I'll be keeping everything crossed for you.
How long will you continue to have intralipids? will you have them up until 12 weeks x
That’s where I’m going on Friday. It’s a 2 hour drive for me but they are the only place giving them without paying to see a consultant at £200 a pop.
Thank you, you too!!
I’ll have one on Friday. If a bfp ill have another at 8 weeks and then another at 12 weeks.
I don’t know too much but my specialists was against steroids before a positive test. I don’t want to put doubt in your mind but something to think about.
Hi there, I had 2 failed transfers, now changed clinic and turns out I have high NK cells and TH1 (though I have a child already from natural conception), I am also about to get tested for ERA,Emma and Alice.At Zita West they told me for my case I will need the following: 2xintralipids infusions (1x when my period before transfer starts and 1x 2 weeks before the transfer then if pregnant I will have 1x agyer positive test and 1xafter 4 weeks), I will also have Prednisolone up to 12 weeks of pregnancy, baby aspirin and Clexane injections.
From what I understood intralipids are just a mix of aminoacids, vitamins and proteins nothing harmful..
So i did intralipids, and steroids .., turns out the steroids caused my testosterone to drop to below 0.01 and with the result our 2 cycles failed as there was no response and nothing grew... i now have to try rebalance my hormones specifically testosterone and see can we do another collection in a few months ... we are soo annoyed .. as no-one explained the risks that steroids could cause this effect
Hello, i know this is an old thread but interested to hear more about your experience with intralipids and steriods - can they affect implantation? I've had three good quality blasts transferred whilst on them and i'm starting to wonder if they have a negative affect? I read a passing comment from a Dr that they could stop implantation but struggling to find any info. xx
So my experience .. they def seemed to help. I think intralipids are probably less risky than steroids, as it is just egg and soya products as far as I know etc steroids however I am on the fence about. I seemed to get positive pregnancy tests however I really don't know if maybe the steroids caused other hormonal issues. Like the issue with my low testosterone that seems to be caused every time I use steroids. So o sometimes worry if I lost 1 of my pregnancies due to the steroid use as I just could not keep my thyroid, nor progesterone stable regardless of medications used. If I got pregnant again I may be slow to start the steroids .. its just soo hard to know really 😪
Hi I do not recommend you to copy paste other patient’s treatment plan. For high NKC, each person is different and the reaction to different treatment plan is different as well. I suggest you go for detailed immunology tests, which will take your blood and test with steroids, IVIG and Intralipid to check your reactions. You should choose the best combination for yourself, the one suits your body. It works differently at each individual. It is not a simple copy paste. Hope this makes sense.
I know someone doesn’t work with Intralipid/IVIG only, or like here someone mentioned didn’t work with steroids etc. So it is better to see with tests results.
Hello SCHNOW, I am not planning on copying anyone’s treatment plans I have simply asked for advice around intralipids. I have my own treatment plan which does include steroids amongst other meds. As my other posts I have high uterine NK cells, low progesterone and my implantation timing is out by 12 hours. All of this was discovered after having an ERA and I am following my consultants treatment plan they have provided. The only reason they are not providing intralipids is because they have temporarily stopped doing them (as far as I understand when speaking to them) and I am trying to figure out if I should fork out at another clinic and use them in combination.
Also you cannot test for uNK cells via a blood test this was done using the ERA which is a biopsy of your endometrium lining. Peripheral NK cells are tested with a blood test
You are correct, usually need to test both ERA and blood. I am wondering if you have high NK in your uterus do they recommend you to go for blood test as well? In my case, I have low NK cell in uterus but high NK cell in blood.
It is interesting because if you need Intralipid but your clinic doesn’t provide how could they justify that the treatment plan will work. Similar thing happened to me from my clinic. They do not provide steroids anymore but only Intralipid. I feel it is not justified but I cannot force them to give me steroids because it is not justified either whether I need it or not. So I went for miscarriage center to have a second opinion and I will have combined treatments. The good thing is both tests confirmed the NKC problem. What I found is sometimes the clinic doesn’t provide one medication is not justified. The feeling is like we run out of stock so just go with what we have and regardless of whether we need or not. Who knows!
The intralipids weren’t on my treatment plan it was an add on but they didn’t offer it at the moment due to COVID so I needed to go to another clinic for treatment if that’s what I wanted to do. After lots of research and speaking to other ladies, NK cells are treated with steroids and intralipids in most cases as they both do the same thing - they completely suppress your immune system and lower the NKC profile.
I have also spoken to the other clinic and they have informed me that intralipids are completely safe as it’s a natural product (e.g. Soy bean and egg) and it’s actively used by athletes.
Thanks for your advice but we have decided to go for steroids and intralipids. Good luck with your treatment and I hope what you decide to do what works best for you.
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