Endometriosis UK
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Zoladex injections before starting IVF - Any experiences please?

Hi all, please has anyone experiences with Zoladex (Goserelin)? I have stage 4 Endometriosis, had Laparoscopy in January. We want to go for IVF, but before we start I will be treated with Zoladex for 3-4 months. I understand this will induce Menopauze for 3 months which apparently might improve our changes for IVF.. I am a bit scared of going through Menopauze, especially the side effects / emotional instability! Has anyone had this treatment and any tips? Many thanks!

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Hiya, I had prostap which is similar to zoladex. I found the side effects started about 1 week into the injection and I had most listed side effects, hot sweats, headaches etc but on the plus side if you are going straight into ivf u need less injections and as soon as you start the stim injections the side effects go away. The hot sweats were quite handy in the cold weather ! Good luck with it and the ivf xx

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Hi Penny, thank so much for your reply! That's helpful to know. Did you go straight to IVF too? And did you get emotional when on the injections? I hope it's going well for you, x x

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Yes I went straight into ivf after the prostap. To b honest I felt so tired and drained on the prostap (probably due to the diagnosis and finding out the cause of the infertility post laparoscopy ) that I felt great on the ivf stim injections, more energy, happier etc. Unfortunately the ivf didn’t work because I also have poor egg quality. Good luck with your journey, ask any questions - happy to answer them xx

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Hi Penny, thanks for your message, I'm so sorry to hear IVF didn't work out, that's really sad. The diagnosis is such as rubbish one and I think gets most of us down! Hope you're okay. It's nice to share experiences with other people going through similar issues x x

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Hi

I had a bad Endometrosis my doctor said the worst he’d seen I had 6 months zoladex which induced menopause and I had all the side effects including suicidal thoughts and another medicine was prescribed to counter the side effects. To cut the long story I had bad reaction to zoladex and my menopause lasted for 5 years and some months ( worst time of my life ) we were meant to start IVF which we ended up cancelling and a year and 7 months after my period started I CONCEIVED NATURALLY . Good luck

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Hi Abbs, thanks for your message. Oh my gosh that sounds terrible! I'm sorry you had to go through such as hard time. I am quite anxious about getting the emotional side effects / low mood / emotional instability etc.. But will just have to see how it goes! But it's so great to hear you fell pregnant naturally! Hope you're happy with your little one :) Thanks for sharing your experiences x x

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Thank you so much for your reply my miracle is keeping me on my toes, but it all worths it. You have every right to be scared zoladex earned me depression and suicidal thoughts I was on antidepressants for about 9 months until I researched and I realised that since my estrogen was severely suppressed that’s what made me nearly killed myself. Honestly if to be honest I would advices people against zoladex, but on a flip side being menopausal for 5 years created a perfect condition for me to conceive naturally since the odds they gave me was very slim. I pray that the treatment you are embarking on will be in your favour and am sending some baby dust your way.

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Thank you so much Abbs, you're very kind. I'm so happy for you and your "miracle", amazing that you have fallen pregnant naturally! Thanks for sharing your experiences and let's hope for some baby dust for us all! :) x x

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hi. How you feeling since your lap? I have stage 4 as well and had what they described as major surgery. Immediately afterwards I was put on prostap to allow my body to heal from the surgery. We didn't know the extent of my endometriosis and it also gave us time to deal with it and decide our next step. We had the ivf tests and had planned on starting last month but unfortunately my husband is very poorly so its temporary / permanently on ice at the moment. I found prostap brilliant I was pain free and the cycle I have had since was very minimal pain. I'm looking into birth control at the moment whilst we get my husband sorted but it worked well for me.

good luck with the ivf. Xx

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Hi Tilly, many thanks for your message. To be honest I felt quite rough after the lap for a few months.. And also my first two periods after lap were absolutely awful, more painful than ever. However it seems to be slightly improving now I think.. I think my tummy needed to heal after the op. (it was also quite a big op!). I am anxious about the side effects of the Zoladex, however hopefully it will mean that I won't have so much pain so that might be nice. I'm sorry to hear your husband is poorly, must be really stressful. I hope he recovers well and you can go ahead with IVF.. It's all such as big deal and overwhelming sometimes! It's nice to hear other people's experiences. Thank you x x

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