Diabetes India

Galvus 500/50 OR Glycomet GP2/500

I had been taking Glycomet GP 2/500 twice daily. Doctor has changed to Galvus 500/50. I can't see much difference other than Galvus being much more expensive.

Secondly Vidagliptin is not sold in US because apparently DPP4 inhibitors trigger joint pains (See Rxlist website).

Should I move back to Glycomet GP2/500. My sugar used to be 113/160 F/PP with galvus its 124/148.

And can I revert to Glycomet gp2 immediately or slowly.

4 Replies

The merits or demerits of drugs can only be answered by the doctor who prescribed.He must be having good reason for doing so when he changed the drug.


Galvus Met composed of two generic drugs viz., Vildagliptin (50 mg) and Metformin (500 mg)

Composition for Glycomet-GP 2 Tablet SR is Glimepiride (2mg), Metformin (500mg).

Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. (Side effects: frequent hypoglycemia).

Vildagliptin is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus. (Caution: Reduce the dose with renal failure)

Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood.

It may be noted that glimepiride + metformin (brand name: Glycomet) is wide prescribed anti-diabetic medications in India. (Total sales - Rs.105 crores) It is affordable and effective.

Consult your diabetologist.








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Thank you Nair Saheb for the elaborate description of the various drugs. Very informative.



Would you please post your diet? By idm you will be able to avoid / lessen medications.

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