Article says iron is not getting across the BBB. Wonder if helps with PD.
They are trying to sell, but Interesting . I already take some of the things mentioned. Says I need Lactobacillus plantarum 299. My probiotic has Lactobacillus plantarum but does not state 299. The article has links, but I don't really understand medical jargon.
Just ordered amazon.com/dp/B00O4BPX9O?ps...
I have the probiotic Neuralli, which contains Lactobacillus Plantarum 128. I wonder if this has the same effect on iron as Lactobacillus Plantarum 299?
Probably not.... And because they are trying to sell, their claim that 299 does maybe Bogus!!!
Looks like 299v does as claimed, this link doesn't mention getting iron across the BBB.
Looks like 299v improves as claimed, this link doesn't mention getting iron across the BBB.
Here are the ingredients. Kind of low on DV of D3. Do we all need more B6? I take a gram of curcumin twice a day, but this whole proprietary blend is only 227 mg.
I have a high school degree, so please do your own research.
Pyridoxine is the toxic form of B6. Only 2 mg is probably not enough to do harm but still, they really should have known better.
Label does not claim 299v. Could be a multitude of LP's.
I am under the impression that probiotics seed the gut and it is not necessary to take 2 a day. Is that true?
It depends. Some probiotics are colonizing and some are not.
I suspsct that low level of ifpn iz vdr rarely a cause but an indicstor of high levels of systemic inflammstjon caused by curre t diets containing processed foods as skmple as bread or fruit juice. As well as infammarion diet has marked ecfects on the balance of bacteria in the microbiome.
supplement with Magnesium
I do...
...the brain cannot take up iron directly from the circulatory system... (does 229v help maybe)
I just want to throw in that I always thought PWP have too much iron in their brains. Iron Chelation is something that has been tried (they used Deferiprone). As I recall the iron went down but the symptoms got worse so they stopped the trial.
Trial of Deferiprone in Parkinson’s Disease 2022 nejm.org/doi/full/10.1056/N...
I question if iron is the problem. Yes, iron is one of the metals found in autopsies of deceased PD patents brains, but it could be due dysfunctional iron utilization.
This is about Traumatic Brain Injury, but may apply to PD as well:
Great!!! another supplement on my shelf that probably won't help
...modifying central iron levels may offer hope for that most elusive of treatments: a disease-modifying therapy for people with Parkinson disease. ncbi.nlm.nih.gov/pmc/articl...
Maybe the key is modifying, Maybe the 299v will help control iron levels. I don't have restless leg often, that and Toe Curls are usually when I am late taking my C/L...
Is it Fe3+ or Fe2+ that cause problems? Which was measured in PD? Was it both?
Is High Dose Thiamine (HDT) a mechanism of repairing a Leaky Brain? And, a reason HDT works.
…Several B vitamins sup.port the health of the blood-brain barrier:
Vitamin B1 (thiamine) deficiency disrupts the blood-brain barrier and supplementation can restore it.
Vitamins B12, B5, and B9 (folate) can restore blood-brain barrier integrity.
thefnc.com/research/nutrien....
gomelgo
I wish I knew the answer to that. I do have a hunch though that having lived in an area that had very high iron content in the water maybe was a contributing factor to my symptoms/diagnosis.
Clinical trial of Lactobacillus plantarum PS128 probiotic supplement in Parkinson's shows improvement in UPDRS and quality of life
Interesting looking supplement
Prebiotic Probiotic Antibiotic... What's the deal?
Restless Leg Syndrome
