New entries in my Parkinson journal following Dr. Mischley's convincing presentation in her second of 24 webinar sessions started in January at the rate of two per month at a price of $10 per session. See educationismedicine.com/
ca. 2/22/20 start fish oil as recommended by Dr. Mischley for omega-3 fatty acid to reduce risk of dyskinesia from levodopa. Hope for effect after 2 months. 1 tablespoon [15ml] per day. Source: “DHA FINEST pure fish oil” by Pharmax, 1200 mg DHA [vs 725 mg in “Finest Pure Fish Oil” from the same source], 150ml, not cheap [$50 or $5 per day].
3/5/20 start Citicoline [CDP Choline] as recommended by Dr. Mischley to reduce risk of dyskinesia from levodopa and possibly reduce the dosage of levodopa by 30-50 % over time. 2 capsules 2x/day or 1 cap 4x/day since taking it with c/l may make the levodopa effect last longer. Source: Citicoline by Jarrows Formulas, 250mg capsules, quantity 120, $30 [$0.75 per day] from Vitacost.
3/5/20 levodopa: start eating a banana [or other non-protein-rich food] immediately at bed rise, after a 12 hour overnight fast, approximately 10-15 minutes prior to taking levodopa, as recommended by Dr. Mischley to reduce morning levodopa-induced queasiness [mild nausea].
For maximum effect of levodopa Dr. Mischley recommends taking it with lemon juice or vitamin C [ascorbic acid powder I dissolve in water], for enhanced stomach acidity.
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Pa-zzi69
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Sound advice. A good way to spare methyl donors and antioxidants. People can also try plain choline or phosphatidycholine (better), which is much less expensive for TMG/betaine supply, which recycles homocysteine back to methionine to lower inflammation, especially for those who are challanged by sluggish MTHFR activity.
Do you know anything about the interactions of Choline with a beta blocker? I wanted to try Choline but have been on metoprolol for as long as I have been diagnosed with Parkinson’s, which is 15 years and understand there is a problem regarding potassium.
Choline is an essential nutrient and your body produces in a small amount and naturally uses it for vital functions including phosphatidylcholine and acetylcholine synthesis, and if you're MTHFR compromised and can't utilize the folate&B12 remethylation pathway, your need for choline increases for the choline (betaine) pathway for compensatory methylation or you'll suffer elevated homocysteine - very bad.
Metoprolol may have anticholinergic (blocks acetycholine at synapse) property in some subjects, but that should not stop you from trying choline rich foods, such as egg yolks and livers when suspecting deficiency, or you could possibly risk dementia among other problems.
If you have heart issues it would be good to test for levels of homocysteine (optimal 6-9) and if elevated, then may be to consider taking choline, see link -
Choline supplies methyl groups essential for converting homocysteine to methionine. Low levels of choline may thus lead to homocysteine buildup, which increases the risk of heart disease and stroke in some people [1, 90, 91, 92].
In almost 4,000 African-American patients, higher intake of choline lowered the risk of stroke [93].
On the other hand, increased consumption of choline-rich foods raises the level of a toxic metabolite: trimethylamine–N–oxide (TMAO).
High TMAO blood levels are associated with a 2.5 times increased risk of stroke and heart attack, but this is more pronounced in people with other risk factors such as diabetes, kidney disease, and high blood pressure [94, 95].
According to the data from over 120,000 adults, increased choline intake was associated with up to 26% higher cardiovascular mortality (from heart disease and stroke) [96].
All in all, the effects of dietary choline on cardiovascular health are inconsistent, and a review of 50 clinical trials came to this conclusion. Further research is warranted [32]."
This is a good advise. It's best to know your homocysteine level to verify your inflammation level (even if physical signs are present), or try filling your dietary need when suspecting deficiency (as in Esther51's headache from an older post). The TMAO hypothesis is controversial among experts, and the few study lacked control group nor actual human clinical data for heart disease to be convincing, yet it's prudent to stay on the cautious side especially when one is unsure of his/her methylation status. However, TMAO concern from a few eggs yolks and occasional liver (especially when not combined with high carbs/sugar) to fill the dietary gap is minimal.
It may or may not be an epigenetic event depending on diagnosis. Some HDs can be reversed or it cannot be if it's due to gene mutation. Watch your triglycerides level and eat healthy nutritious diet watching fat/carb ratios and exercise. If you provide your body what it needs and support it to be able to fight off oxidative stress, you're less likely to cause a gene mutation.
Thanks for the post on HD. My husband had 'heart disease' and overcame it by changing the diet. I have never had heart disease. We also have the MTHFR gene and take methylated B12 and mthf folate.
Close to half the human population have SNPs MTHFR, but some are more compromised than others. However, if you're an undermethylator (with high histamine) and have neurological symptoms such as depressions/anxiety, you should NOT over supplement with any form of b9 because it'll depress your serotonin. It's best to get your nutrition from diet in that case.
No problem. I'd love to hear back if that helps you at all. Hope your headache has eased up by now.
Why would you need to increase the acidity of your stomach with a weak acid like ascorbic acid? Your stomach contains extremely strong acid to begin with. Levodopa is not metabolised in the stomach!!
Fish get their DHA from algae they consume. But then the fish are largely contaminated with heavy metals and other things. Instead of paying a lot to get those contaminants out, why not just take DHA derived directly from algae in the first place? It's less expensive and very pure. I take "Non-Fish Vegan Omega-3 DHA" made by Deva. Vitacost has it.
Hello, can you please share your preferred source for actual raw vitamin C pills? It is hard to decipher what is best but I have gathered from reading that ascorbic acid is not as good as the real vitamin C. Thank you.
By the way, if you're trying to maximize the levodopa, you'll need a low Ph - meaning the GOL pills won't help for that purpose. For that, you'll need to use either lemon juice or pure ascorbic acid powder (not the buffered kind) strictly to improve the stomach acidity.
Thank you for clarifying. I’m not presently on levodopa. Coincidentally I have the GOL vitamin C. I was on the right track without knowing it. I also use the GOL MCT oil and vitamin D and B.
A while ago I posted a thread about liquifying your levodopa by combining each dose with 200 mg of vitamin C. Summary: 5 doses of Sinemet are ground up and liquified with 1,000 mg of vitamin C. The desired result is the following:
Liquid levodopa/carbidopa produces significant improvement in motor function without dyskinesia exacerbation n.neurology.org/content/47/...
Thank you silvestrov for reinforcing what I learned from dr. Mischley and forwardedunder your name to my personal distribution list of Parkinson patients !...
That is a good question. I am in the process of doing my taxes and have not summarized my deductions. Off the top of my head I do not think I will because my health expenses were at a minimum. I had a healthy year and the total of out of my pocket expenses was minimal....say less than 40$ (2 prescriptions).
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DHA for dyskinesia also improving sleep?
Probiotics? Are they helpful? BioKult? Dr. Mischley says no probiotics but not why? 
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