The following method for liquefying L-dopa has been shown to have faster on time with less dyskinesia. It is perfectly safe and as it will be shown, has been used with children with amblyopia (lazy eye).
Simply put, it is liquifying 5 doses of L-dopa with 1,000 mg of vitamin C/ascorbic acid, is stored in the refrigerator and a dose is extracted when needed.
[Preparation of a levodopa/carbidopa solution in ascorbic acid (citridopa) and chromatographic and electrochemical assessment of its stability over 24 hours].
"Thus, a patient taking 5 tablets of Sinemet Plus a day, would pulverize them in a glass, ceramic or marble mortar and add them to a measuring cup containing a 1 gram tablet of vitamin C (Redoxon) dissolved in 500 cc of cold water. This would be shaken or stirred until the Sinemet powder had dissolved."
Of course there are 1,000 mg capsules of vitamin C available which can be emptied into water. Will they completely dissolve in water like redoxon? Standard 1,000 mg capsules of vitamin c are much less expensive than redoxon:
Using liquid levodopa in the treatment of Parkinson's disease. A practical guide.
"A solution of levodopa and carbidopa, stabilised using ascorbic acid, offers a means of delivering a titrated amount of levodopa at regular intervals. Solutions pass through the stomach faster than solids, affording more rapid symptomatic relief in some patients with Parkinson's disease."
Oral levodopa/carbidopa solution versus tablets in Parkinson's patients with severe fluctuations
"Four patients with Parkinson's disease, optimally treated with levodopa/carbidopa (LD/CD) tablets but experiencing severe motor fluctuations, underwent an open trial of a levodopa/carbidopa/ascorbic acid solution (LCAS) orally at timed intervals. LCAS reduced bradykinesia, decreased dysfunctional dyskinesia, and increased functional “on” time when compared with previous LD/CD tablet therapy. Oral LCAS allowed better titration of levodopa dosage and offered a more predictable response than LD/CD tablets. Preparation and oral consumption of LCAS was easy and inexpensive. LCAS may be a practical alternative for patients whose motor fluctuations fail to respond to optimal therapy with LD/CD tablets."
[Gastric acid secretion and absorption of levodopa in patients with Parkinson's disease--the effect of supplement therapy to gastric acid].
"We measured the pH and amount of collected fasting gastric juice. Gastric acid secretion was decreased in 22 patients (58%). In ten of these 22 patients, 30 ml of lemon juice was prescribed in every administration of levodopa as a supplement to gastric acid for two weeks. Increases of L-dopa concentration after 60 min. and 180 min. were observed after lemon juice supplement therapy. Among the Parkinson symptoms, rigidity, akinesia, and small step gait were improved in every case except one patient who showed decrease of L-dopa concentration at 180 minutes."
24% of lemon juice is vitamin C and the PH of lemon juice and vitamin C/ascrobic acid is similar: 2.2 - 2.4 PH
Lemon juice: fda.gov/Food/FoodborneIllne...
Vitamin C/ascorbic acid: metabolicmaintenance.com/pr...
I previously mentioned this solution was used for children with amblyopia (wikipedia):
"Amblyopia, also called lazy eye, is a disorder of sight due to the eye and brain not working well together."
Development of two stable oral suspensions of levodopa-carbidopa for children with amblyopia.
" In the suspension containing ascorbic acid, the mean concentrations of levodopa-carbidopa were above 93% and 92% for 14 days at 25 degrees C, and 93% and 92% for 28 days at 4 degrees C. This liquid formulation was administered to 15 children (mean age: 5.6+/-1.4 years) with amblyopia."
There are some questions which have to be contemplated. What about people taking slow release levodopa (Sinemet CR/Madopar CR)? Vitamin C does come in slow release tablets but at what dose of vitamin C would need to be taken to maximize the CR dose?
This method of liquefying levodopa would work for those using 99% pure levodopa as derived from mucuna pruriens but how well will mucuna pruriens supplements work which are not 99% pure levodopa? Most range from 15 - 50% and how easily will the rest of the plant dissolve?