Liquefy your L-dopa

Liquefy your L-dopa

The following method for liquefying L-dopa has been shown to have faster on time with less dyskinesia. It is perfectly safe and as it will be shown, has been used with children with amblyopia (lazy eye).

Simply put, it is liquifying 5 doses of L-dopa with 1,000 mg of vitamin C/ascorbic acid, is stored in the refrigerator and a dose is extracted when needed.

[Preparation of a levodopa/carbidopa solution in ascorbic acid (citridopa) and chromatographic and electrochemical assessment of its stability over 24 hours].

"Thus, a patient taking 5 tablets of Sinemet Plus a day, would pulverize them in a glass, ceramic or marble mortar and add them to a measuring cup containing a 1 gram tablet of vitamin C (Redoxon) dissolved in 500 cc of cold water. This would be shaken or stirred until the Sinemet powder had dissolved."

ncbi.nlm.nih.gov/pubmed/778...

Redoxon: amazon.com/s/?ie=UTF8&keywo...

Of course there are 1,000 mg capsules of vitamin C available which can be emptied into water. Will they completely dissolve in water like redoxon? Standard 1,000 mg capsules of vitamin c are much less expensive than redoxon:

amazon.com/Swanson-Vitamin-...

Using liquid levodopa in the treatment of Parkinson's disease. A practical guide.

"A solution of levodopa and carbidopa, stabilised using ascorbic acid, offers a means of delivering a titrated amount of levodopa at regular intervals. Solutions pass through the stomach faster than solids, affording more rapid symptomatic relief in some patients with Parkinson's disease."

ncbi.nlm.nih.gov/pubmed/914...

Oral levodopa/carbidopa solution versus tablets in Parkinson's patients with severe fluctuations

"Four patients with Parkinson's disease, optimally treated with levodopa/carbidopa (LD/CD) tablets but experiencing severe motor fluctuations, underwent an open trial of a levodopa/carbidopa/ascorbic acid solution (LCAS) orally at timed intervals. LCAS reduced bradykinesia, decreased dysfunctional dyskinesia, and increased functional “on” time when compared with previous LD/CD tablet therapy. Oral LCAS allowed better titration of levodopa dosage and offered a more predictable response than LD/CD tablets. Preparation and oral consumption of LCAS was easy and inexpensive. LCAS may be a practical alternative for patients whose motor fluctuations fail to respond to optimal therapy with LD/CD tablets."

neurology.org/content/43/5/...

[Gastric acid secretion and absorption of levodopa in patients with Parkinson's disease--the effect of supplement therapy to gastric acid].

"We measured the pH and amount of collected fasting gastric juice. Gastric acid secretion was decreased in 22 patients (58%). In ten of these 22 patients, 30 ml of lemon juice was prescribed in every administration of levodopa as a supplement to gastric acid for two weeks. Increases of L-dopa concentration after 60 min. and 180 min. were observed after lemon juice supplement therapy. Among the Parkinson symptoms, rigidity, akinesia, and small step gait were improved in every case except one patient who showed decrease of L-dopa concentration at 180 minutes."

ncbi.nlm.nih.gov/pubmed/820...

24% of lemon juice is vitamin C and the PH of lemon juice and vitamin C/ascrobic acid is similar: 2.2 - 2.4 PH

Lemon juice: fda.gov/Food/FoodborneIllne...

Vitamin C/ascorbic acid: metabolicmaintenance.com/pr...

I previously mentioned this solution was used for children with amblyopia (wikipedia):

"Amblyopia, also called lazy eye, is a disorder of sight due to the eye and brain not working well together."

Development of two stable oral suspensions of levodopa-carbidopa for children with amblyopia.

" In the suspension containing ascorbic acid, the mean concentrations of levodopa-carbidopa were above 93% and 92% for 14 days at 25 degrees C, and 93% and 92% for 28 days at 4 degrees C. This liquid formulation was administered to 15 children (mean age: 5.6+/-1.4 years) with amblyopia."

ncbi.nlm.nih.gov/pubmed/113...

There are some questions which have to be contemplated. What about people taking slow release levodopa (Sinemet CR/Madopar CR)? Vitamin C does come in slow release tablets but at what dose of vitamin C would need to be taken to maximize the CR dose?

This method of liquefying levodopa would work for those using 99% pure levodopa as derived from mucuna pruriens but how well will mucuna pruriens supplements work which are not 99% pure levodopa? Most range from 15 - 50% and how easily will the rest of the plant dissolve?

Best wishes,

Rich

31 Replies

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  • I read a response you wrote re how to administer a version of your pure l-dopa protocol to a woman whose husband who had trouble swallowing. Seems like that would apply. I currently take 300-350 C/L daily in 50mg increments. I am planning to try your protocol subbing the morning and late afternoon dose. I had already purchased Vit C powder, so I will now try it in liquid form with quercetin w/bromelain.

    Thank you!

    Julie

  • I tried 99% pure levodopa from mucuna pruriens with quercetin/bromelain, EGCG, vitamin C and salmon oil all dissolved in a liquid form. I can honestly say it was one of the nastiest combination of flavors I have ever swallowed. Though it worked immediately......

  • I thought it was Q/B or ECEG (I only read it once). I was juicing marijuana leaves for a while. It was vile tasting. I've also been researching black seed oil which many reviewers liken to motor oil and give up after one or two tries.

  • it was the salmon oil, im getting shivers right now

  • I don't understand?

  • I'm thinking of taste, when I was little they used to give us cod liver oil, gross!

  • EGCG has chemical action similar to carbidopa/benserazide ; quercetin has chemical activity similar to entacapone; 200 mg of vitamin C aids in the absorption of both 99% levodopa from mucuna pruriens and EGCG. 1,000 mg salmon oil helps the easily methylated and oxidized supplement EGCG to be absorbed better. Yes liquifying it all together made it work immediately and in a robust manner but it tasted ghastly.

    A few references:

    Green tea polyphenols: novel irreversible inhibitors of dopa decarboxylase.

    ncbi.nlm.nih.gov/pubmed/113...

    Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

    ncbi.nlm.nih.gov/pmc/articl...

    Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition.

    ncbi.nlm.nih.gov/pubmed/127...

  • Dear Silvestrov,

    I have been reading a number of your messages and am grateful for your research and your sharing of it. I wondered if you have finished your documentary because I'd be interested in watching it. My 79-year-old mother has been recently diagnosed with "parkinsonism" by a UCSD movement disorder specialist/neurologist. She has had shortened gait, a few falls (from not lifting foot high enough to step) and some reaching for words in explaining herself. I don't know what to do. I don't trust the Sinemet because of the Carbidopa and how it seems to bind the vitamin B in the body and the supposed increase in Parkinson's death rate since its introduction. Also, the short window of effectiveness of Sinemet and the added dyskinesias people are left with afterwards. The best option seems to use Mucuna Pruriens perhaps supported by amino acid therapy or the Hinz Protocol. Then I find that Dr. Hinz has had his license suspended for a period of years, perhaps spurred by a mental health crisis, but the result was a good number of people who felt they were not properly treated...and something about potentially false supplement claims??? I'm scared for her to go the conventional method. She is scared to go the homeopathic way. My question to you is do you know of the Hinz protocol and if so, what do you think of it? I am researching, reading and trying to figure out the best thing to do, but I'm afraid I'll make a mistake, not being a doctor, and recommend something that will hurt my precious mom, who has been my rock my whole life. Please forgive me, I'm just feeling so unsure of how to advise her. How have you done it? How can I get a medical doctor who will agree to oversee a homeopathic protocol? I found one in the San Diego area, but my mom worries about some questionable reviews. I know that it's a lot to ask, but what would you do if you were me in advising and caring for my mom?

    Any guidance would be greatly appreciated,

    Sarah

  • Sarah,

    First of all, here is the link to my documentary:

    vimeopro.com/user60766261/r...

    I have come to categorize Parkinson's disease as a 'trial and error' disease because every person with Parkinson's seems to react differently to the various therapies and everyone seems to have a different but similar version of the disease.

    In my doc the second video is on Amino Acid Management featuring the Hinz protocol. I have had people on the therapy who have contacted me and it seems to help them but it is expensive and the amount of (mucuna pruriens) levodopa they take is prohibitive. On average, every person takes about 1 bottle every 2 days and this translates into approx. 11 grams of 40% levodopa a day. Cramping and nausea are common side effects of the therapy.

    The easiest solution to the levodopa quandary is for her to try Zandopa (HP-200). It has been tested on PD patients and though it is a powder it is mixed with water and thus it too is in a liquid form. Zandopa can be purchased on amazon.com.

    amazon.com/zandopa/s?ie=UTF...

    An alternative medicine treatment for Parkinson's disease: results of a multicenter clinical trial. HP-200 in Parkinson's Disease Study Group.

    ncbi.nlm.nih.gov/pubmed/939...

    Regardless of the form of levodopa someone takes it causes a subclinical niacin deficiency and 250 mg of slow release niacin is recommended for this and an additional reason. One man went on 1,000 mg of niacin per day and it improved some of this symptoms but he had to quit taking it because of nightmares and extensive flushing. A later article showed that niacin relieved inflammation from the GPR-109a receptor (Niacin receptor 1):

    Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson’s disease symptoms without side effects

    ncbi.nlm.nih.gov/pmc/articl...

    Since a meat consumption interferes with the absorption and conversion of levodopa into dopamine, a (relatively) meat-free diet is recommended with breakfast and lunch being veggie meals and some form of protein consumed at dinner.

    The problem with this diet is the major source of cobalamin (vitamin B12) is from red meat and because any form of levodopa can raise homocysteine levels - a non-protein amino acid associated with vascular disease and dementia, by eating a minimal amount of meat you need to add a B12 supplement. The most potent form of B12 is methylcobalamin and B12 is a co-factor for the conversion of homocysteine to methionine. Studies have shown that oral/sublingual B12 is just as effective as B12 injections in raising cobalamin levels. In a Dutch article they stated that large dose of methylcobalamin, larger than a doctor would prescribe, is perfectly safe. ALS patients were given 50 mg/day of intravenous methylcobalamin per day with no side effects. Normally 1 mg of B12 is considered to be a 'maintenance' dose but larger doses are required to PD patients because of known B12 deficiencies and the use of levodopa. I have taken 5 mg/day sublingual methylcobalamin for years with no side effects. Low B12 levels is associated with poor cognitive function and peripheral neuropathy.

    peripheralneuropathycenter....

    Treatment with high dose vitamin B12 been shown to be safe for more than 50 years

    stichtingb12tekort.nl/weten...

    If you either take B12 or folate you should take them both. They are like the dynamic duo of B vitamins because they work synergistically. Methy folate (methyltetrahydrofolic acid) is the bioavailable from of the vitamin and it also helps to lower homocysteine levels associated with levodopa. By itself folate has been shown to be neuroprotective in PD:

    Folic Acid Linked to Parkinson's Disease

    webmd.com/parkinsons-diseas...

    400-800 mcg/day of Methyl folate is sufficient unless the patient is known to have the MTHRFR mutation then large doses of folate are required:

    healthunlocked.com/parkinso...

    If you take sinemet/madopar you have to take pyridoxine (B6) but if you take Zandopa you do not. Sinemet/madopar causes a deficiency of B6 but taking more than 5 mg of pyridoxine per day causes the immediate conversion of (mucuna pruriens) levodopa into dopamine in the body. Thus it prevents the levodopa from reaching the blood brain barrier to be converted into dopamine in the brain.

    So start with Zandopa, 250 mg slow release niacin, 5 mg sublinqual methylcobalamin and Methyl folate. Keep in mind that every person has a uncertain response to levodopa and it may be required to take 4-6 doses a day - it depends on individual response.

    This is enough info for you to mull over so after watching the doc and reading the links I sent you let me know how your mother responds.

    Rich

  • Bless you a million times over. The knowledge you have accumulated is amazing and so incredibly needed with the state of care for Parkinson's at this time. I am so happy to have the link for your documentary and will apply myself to it! Thank you, Rich. I am so grateful for your help.

    Sarah

  • Dear Rich,

    I am so appreciative of your documentary material. I've been following it for hours and taking notes. I can't believe you have both sides of your brain going with being an artist and understanding this intricate and complex medical information. I like your recommendations above and am researching further with this in mind. I would really like to know your view on Carbidopa. It scares me because of this study:

    ncbi.nlm.nih.gov/pmc/articl...

    Conclusion

    "Between 1960 and 1974, the only prescription form of L-dopa available was the single-ingredient form that was associated with a decreasing death rate.61 In 1975, the original combination L-dopa/carbidopa drug (Sinemet®) was approved by the US FDA. Between 1976 and 2011, the CDC documented a progressive increase of 328.7% in Parkinson’s disease deaths that crossed age, sex, and ethnic boundaries.61,84 In addition, no effective way has been discovered to truly stop what has been described as neurodegeneration.

    The mechanism of action for carbidopa and benserazide induces irreversible binding to and permanent deactivation of PLP and PLP-dependent enzyme molecules, potentially inducing a negative impact on over 300 enzymes and proteins."

    ----------------------------------------

    I have a sibling who will only listen to large, double blind studies, which, of course, are not so easy to find with more homeopathic therapies. I've also noted that the large ones for Sinemet and its various different formulations seem to be funded by the large drug companies that sell the product, listed in the conflict of interest statement on the medical journal studies themselves! So how are we supposed to trust that this is an unbiased result that is not skewed to represent the product from which they are making money?

    Also, there is a site called Askapatient.com, When you look up Sinemet, there are, yes anecdotal stories of people who have had horrible experiences with hallucinations and paranoia with their loved ones on this medication. And these are written off as "anecdotal," but geez, it's hard not to listen to caregivers discussing their experiences.

    Then you go to another site for patients' experience and it's a much cheerier outlook:

    patientslikeme.com/treatmen...

    but I noticed that they partner with drug companies as well. And maybe that is because it is valuable info for the drug co.s, but it's just strange looking at two very opposing pictures of the same situation.

    I know that you said everyone is so different. I want the very best for my mom. The hard part is, family pressure to follow the conventional accepted medical route, confirmed by studies funded by conventional suppliers. I have seen doctors make major mistakes (just last month my friend's husband with brain cancer was put on a chemo drug that made him violently sick. The doctor had left on vacation and not left a backup doctor on duty, something that was confirmed by the shocked hospital staff. They went to another doctor who said he couldn't believe the first doctor had used that chemo agent because it was no longer used in the industry and was considered highly toxic and ineffective).

    The other problem is that the amino acid Hinz protocol therapy has so many supplements that they sell and is expensive, as you said. It comes across to a sibling as a marketing ploy.

    Do you think there are many doctors willing to work with patients who want to do these homeopathic, less beaten path ways?

    I would really value hearing your thoughts,

    Sarah

  • I will get back at you later because I am working a heavy schedule this week.

    Rich

  • Thank you silvestrov ,

    Two years back I was having difficulties for my medication to kick off in early morning so my neurologist advised me to dissolve half a tablet of sinemet 100/25 in a small cup of soda (7 up or sprit o mountain dew) it was working quickly but Soda in general is full of sugar and not good for general health .

  • Yes soda is a very unhealthy product and I have not drank it in years. I probably had 1 mouthful in 10 years before spitting it out. The ph of soda is acidic though slightly less than lemon juice and ascorbic acid:

    google.com/search?q=ph+of+s...

  • I used vinegars mixed with warm water.to up digestive juices (hydrochloric acid) older stomachs can benefit,

  • just learned that couple years ago, university of Virginia found lymphatics in the brain....that excreted three pounds of toxins and PLACK.....during sleep. From dr mercola's article on revised stance on wheat and barley allergies.

  • I am using half lime with Sinemet plus and half Entaphone tablet for every dose but having slight dyskinesia. Practicing for last six months. I don't have tremors.

  • Has this "sinemet juice" been speed-tested against the ODT (orally disintegrating tablet) which when chewed and swallowed with a glass of liquid would seem to offer the same tendency to take effect quickly. The ODT sinemet has a mint taste and is a cheap generic (my copay is $20 for my 1080 pill 90-day supply. I formerly chewed the regular sinemet tablets, which are bitter and made life just a little more miserable by their awful taste. Taste problem solved with ODT, and I can't imagine why they should be any slower than your sinemet solution, if they are washed down with your liquid of choice after thorough chewing and swallowing with a beverage. Rytary was tested head-to-head against regular sinemet but not against sinemet CR or very-tiny-but-super-frequent doses of ODT (to simulate continuous infusion into the stomach.) Rytari added about an hour of on time per day without dyskinesia, which isn't bad. A few more improvements like that and life might seem a lot better!

  • Thanks Silverstrov

    It is very useful info, and pleased to have this formula and supporting info.

    Those i know of who dissolve their Sinemet have done it because of wearing off and dyskenesia. They do not take a dose at set times but sip the liquid all day. The aim is to keep a constant level of levadopa in the body.

  • What to say. It's mostly above my head I'm afraid.

    Now, I'm to have a Duodopa procedure for the same reason........keeping a constant level of the 'stuff' in my poor old body.

    The 2 specialists, Gastro Enterologist and Neurologist have to 'gang up' together and work out the time both can do the procedure. I'm still waiting to hear.

    Dyskinesia is wearing me out....I jerk all day...hate it.....also have NUMB TOES, BURNING HEELS, AND I HAVE LOST 2 TOENAILS FOR NO REASON. Is this Parkinson's or do I have Diabetes aaas weeel.

    This condition is beating me at the moment......hard to laugh but easy to cry.

    'Keep on the sunny side of life' Where is it?

  • advancedPDguy

    Hi. You mentioned the ODT type of Sinemet in your post 8 mths ago. Are you still able to get it? Express Scripts cancelled my prescription & I am not able to find it now. I called the Mylan, the manufacturer, & they said it would be September, but I still haven't heard anything.

  • I take Parcopa. It's blue & minty & dissolves on my tongue. It works well. I do have some off times but not real bad. I've been takng it approximately 9 years & still only take 3--5 per day.

  • What strength do you take laglag?

  • 25/100. The manufacturer is Mylan. The pharmacy gave me some made by Sunxxx? one time and it did not work as well. It took a lot of talking but I talked them into changing it back. Funny thing is, Mylan makes the generic.

  • You said too mix five tablets pulverized levodopa with one gram citric acid in 500 cc's. That sounds like a lot of water did you mean 5 cc's 500 milliliters?

  • The following link ataes 1000 cc of water is 2.2 pounds....so 500 cc is 1.1 pounds.

    google.com/search?q=how+muc...

    And I just noticed the additional links on the search page give handy dandy information about the weight of breast implants. More info than was required....lol

  • Okay thank you okay thank you I guess it's just over a pint not as much as I thought.

  • Today has been great. Except for one episode of paraesthesias it has been smooth like whisky

  • Hi

    My husband

    Has takes dopamine in capsule form

    2 different size doses

    Throughout the day..

    I don't see how I could apply this to him

    Although the idea sounds good

    As his down time is very significant and so his the Dyskinesia

    ??

  • What sizes and forms does his levodopa come in?

  • Dear s,

    I tried it today. So far onset of on time is very fast and the duration of on time MODESTLY raised.i shall continue for a week and report back to you.

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