Has anyone had success reducing levodopa-induced Dyskinesias after using Dr. Laurie Mischley’s regimen? (High DHA Fish Oil, Citicholine)

[PNWpWp2014d]

I would like to know if anyone has been successful in reducing or eliminating levodopa-induced dyskinesias after using Dr. Laurie Mischley's regimen (High DHA Fish Oil and Citicholine). There were quite a number of posts here about 2 months ago. I took the fish oil one extra month because there was no change at all—still suffered dyskinesias. I have one week left on the high DHA fish oil then I will stop that and start the CDP Citacholine. I'm hoping for some positive input since my motivation is dwindling and my dyskinesias continue to plague my limited "On" time. Thank you for any information, experiences...

[JayPwP]

healthunlocked.com/cure-par...

[park_bear in reply to JayPwP]

Thanks for posting the link. I will add that Laurie Mischley does not recommend citicoline to reduce dyskinesia- she recommends it to reduce levodopa usage.

Fish oil does seem to reduce my dyskinesia.

[Allypally49 in reply to park_bear]

Do you know what measures to take in reducing it to blind out if its working?i. e missing out once or 2 times a day etc

[park_bear in reply to Allypally49]

If you are referring to citicoline, my recommendation is if you are not taking it, don't start; if you are taking it, don't stop. If you are taking it, get your TMAO level checked.

healthunlocked.com/cure-par....

healthunlocked.com/cure-par...

[PNWpWp2014d in reply to park_bear]

Thanks. Yes, I am very familiar with the L. Mischley information—I’ve read and watched it many times. So, yes, I know the dyskinesia help I’m asking about only applies to the high DHA fish oil part of her regimen (the first step). That is the part that does not seem to be working for me after two months. Maybe I will try a third month of the high DHA fish oil. I take the brand sold in Dr. Mischley’s pharmacy (Pharmax DHA Finest Pure Fish Oil). I’ve been taking 1 tablespoon with my first meal (brunch at 11-ish). Maybe I will divide it up to 1 teaspoon with brunch and 1 teaspoon with dinner (I only eat two meals). I hope it works—my dyskinesias get so violent I sometimes need to wear a neck brace. But, hey, it sure is a great way to lose weight 😁

[park_bear in reply to PNWpWp2014d]

Reflecting upon the comment below, wondering if what is really going on here is vitamin B6 deficiency which is causing muscle spasm and masquerading as dyskinesia. Important information about B6 deficiency here: htaps://healthunlocked.com/cure-parkinsons/posts/136869228/levodopa-medications-and-vitamin-b6

[Specterishot in reply to park_bear]

Park bear can u kindly repost the B6 link? it will not open for me. Thanks SO much

[park_bear in reply to Specterishot]

Oops. It was accidentally corrupted by Parkinson's tremor. This should work:

healthunlocked.com/cure-par...

[billybobAK]

I have had good success lately using vitamin B 6 100 mg ashwaganda 4x100mgtaken with the last dose of ld

[mitochondria in reply to billybobAK]

Good to know that B6 and Ashwagandha combination is working for you billybobAK .

I have been using only mucuna and ashwagandha for two years. I experimented removing Ashwagandha recently. Dyskinesia was bad. Putting back Ashwagandha (in the morning) and 50 mg B6 along with one-meal-a-day dinner after the last dose of mucuna. B6 in the morning reduced my daytime on-period of mucuna. Still not as good as my pre-experiment days, but dyskinesia is getting better.

[billybobAK in reply to mitochondria]

I had severe dyskinesiauntil recently figuring out the right dose of b6 (100mg) and ashwagonda (400mg with pepper) taken with the last dose of LD. Reduced the time and severity down to 20% of what it was. Good luck with your experiments. I also start my day with 300mg of ashwagonda.

[billybobAK in reply to mitochondria]

I used macuna for about 5 years but still was having severe biphasic dyskinesia . Adamintine and time released versions didn’t work nor did Gabapentin. B6 p5p version has been a life saver.

[billybobAK in reply to mitochondria]

I'm using p5p b6

[park_bear in reply to billybobAK]

I'm wondering if what you had was vitamin B6 deficiency causing muscle spasm and masquerading as dyskinesia. B6 deficiency can cause peripheral neuropathy which has symptoms such as numbness, prickling, or tingling in feet or hands. Your thoughts?

[billybobAK in reply to park_bear]

I think leva dopa is the problem comes on when I ramp up in the morning and ramp down in the afternoon. More ld caused worse dyskinesia

[BeedieBird]

Yes, I've had success with both dha fish oil, I didn't discontinue use of this but take citicoline.. citicoline stopped my dyskinesia even before I started reducing Sinemet. Rytary has also helped in reduction of Sinemet and Levodopa induced dyskinesia. Those 3 combined for me. Does she say to stop taking the DHA oil?

[PNWpWp2014d in reply to BeedieBird]

Good question: "...Does she say to stop taking the DHA oil?” Does she?

[Zella23]

My husband is taking the fish oil, and was already taking the Citicoline. It seems to have reduced some of the dyskenesias but not reliably so. He reduced his .Rasagaline, because as soon as he took that the dyskenesia would start up within an hour. He’s cut down on the Rasagaline to . 5 mgs a day but it has slowed him down. He only rakes 3 x 125 mgs of levadopa otherwise he d be dancing off the ceiling with the dyskinesias. Amantadine helps but it is such a difficult balance to get it all of the meds working in balance.

[Kevin51 in reply to Zella23]

Hi Zella,

I am still taking DHA @ 2gms /day but the jury is still out on that. I found some motor symptom benefit in adding ER Ropinerole @ 2mg/day (minimum possible dose - no obsessions so far except for PD!). I get diphasic dyskinesia so have started to delay taking SInemet till late morning and rely on my Amantadine and Ropinerole till then to have a dyskinesia free morning albeit with more tremor. I feel my way though the rest of the day with 50mg Sinemet so the DK which kicks in is not too bad. I was surprised I could do without Sinemet for most of the morning . It's not easy trying to optimise 3 different meds so I am going to consult a well known neuro next week who's witten a recent paper on this topic!

Best

Kevin

[Zella23 in reply to Kevin51]

Hi Kevin, yes really hard to balance the meds. Recently after cutting the Rasagaline in half and a couple of weeks of cutting it down to nothing. He restarted just taking a half in the mornings and it seemed to help and the dyskenesia wasn’t so intense. He’s now taking the other half when he goes to bed and it doesn’t seem to have any disastrous effect on his sleep so we ll stay with this for a while.

He does also have the Neupro patch same strength as your Ropinerole, 2 mgs. He can also go a long time without meds just slows down but can still function. He s had PD dx for 9 years so Neuro thinks he should have more meds but my husband can’t take the side effects and can function reasonably well on the amount he takes. Going to keep on the fish oil, but much less Citicoline than Dr Mischeley recommends.

Good luck with the Neuro will be interesting to see what he says. We’re balancing 3 meds plus the patch.

Forgot to add since adding in above supplements my husband is sleeping better.

[1LittleWillow]

I have so much challenging stuff going on in my life right now that it's been impossible for me to find time to post anything comprehensive about what I've been doing.

I had started citicoline a while back (last year, don't have time to look up dates right now) and was experiencing some improvement. This was prior to doing Dr. Mischley's DHA protocol. Because I was having some issues that I couldn't figure out (STILL trying at the moment), I decided to stop it. I only took a small dose for a couple of weeks.

I started the high-dose DHA oil in November, and did that for 2 months straight. After reading ParkBear's (I think?) posts about it, I never restarted the citicoline after finishing the DHA.

I'm continuing to take a DHA/EPA supplement with a lower, but still higher than normal, amount of DHA. I still get dyskinesia, but it's reduced by about 50% from where it was before I did doctor Mischley's protocol. It's tolerable now, and occasionally I have days where I don't really notice it.

FYI, I take mucuna plus carbidopa instead of Sinemet.