Covid antibodies lost in short time periode

[Reinhard]

Wanted to share my experience with vaccination :

After two times Biontech I had 1036 AU/ml (< 50 negativ) in mid of May. On Thursday this week I had my 6 months check and asked to add Covid antibodies just to know when to get a 3rd booster vaccination. The new value is 22 only. So I have lost nearly all antibodies in less than 4 months.

I got 3rd vaccination yesterday and will ask for monthly checks of antibodies in order to get a general feeling how offen I need booster vaccinations.

I should add that I need IvIg monthly.

I have to admit that this rapid loss of antibodies is not only surprising my docs but it is also quite disappointing and scary for me.

To end my post with something positive...

I am still mrd- after V+ O (5/2015 - 9/2018).

Reinhard

[Poodle2]

Thanks for sharing, this is really scary...I had my second jab in May and by the sound of it, I shouldn't hesitate to have the booster as soon as I can.

Glad to hear about your mrd-, that's fantastic!

[Justasheet1]

Thanks for that info. Sounds like you are doing everything right to stay healthy. Jeff

[ElMaga]

For some reason I can't write a post or search past posts. I just got my Labcorp results from my 3rd Moderna. First test in April was positive but only 6.87 and the second in June was 3.8. Today I received my results of 1130. So much better; since I can't search the former posts, how does that fare? what are the scores of healthy people? anything.

[country76 in reply to ElMaga]

Congratulations!! On you taking any Cll treatments?

[ElMaga in reply to country76]

yes but with my Oncologist permission I went off two weeks before and 3 weeks after; he says mine so indolent that he hasn't been worried but I certainly wouldn't do without his permission and monitoring; my blood work this week was the same as before

[ElMaga in reply to ElMaga]

anyone else have access to the reports with the antibody numbers?

[newyork8 in reply to ElMaga]

Which treatment do you take?

[ElMaga in reply to newyork8]

Ibrutinib 280

[newyork8 in reply to ElMaga]

Thanks and good luck. Maybe the lower dose Ibr helped your system develop antibodies.

[AussieNeil Partner Administrator in reply to ElMaga]

Can you search from here?healthunlocked.com/cllsuppo...

Please email [e-mail] for assistance if you can't post.

Neil

[ElMaga in reply to AussieNeil]

Does anyone remember the article that charted antibody responses to vaccine in healthy people, those with CLL, etc.?

[AussieNeil Partner Administrator in reply to ElMaga]

gardening-girl replied with useful information in this post: healthunlocked.com/cllsuppo...

[unairdefamille in reply to ElMaga]

CONGRATULATION!!!!!!!!!!!

[SeymourB]

Reinhard -

Was you most recent test the identical same test panel as before?

Do you get non-COVID total IgG, IgM, and IgA tests also?

=seymour=

[Reinhard in reply to SeymourB]

Test was the same as in May.Last blood test in March this year IgG, IgM and IgA were tested (all too low) - but not this time.

[Edalv]

Remember antibodies are one of the defense mechanisms the body has to protect against infections. The immune system has other means of protection after vaccination that we can’t quantify right now. I think getting a booster is a wise idea for people with CLL. I probably get my 3rd shot soon, but I want to discuss it with my doctor first when I see him in November.

[bennevisplace]

No-one should be surprised to see their vaccine-acquired immunity decline over several months. Especially more elderly CLL patients and/or with more advanced disease.

These are my own inferences from a recent Estonian study in volunteers who had received the Pfizer BNT vaccine. Their IgG levels starting to wane after 6 weeks, to a median of only 7 percent of peak values after 6 months. Antibody levels correlated negatively with age and positively with vaccination side effects.

87 percent of volunteers developed spike-specific memory T cells. However, their levels were negatively correlated with senescence of CD8+ cells, a feature of advanced CLL.

thelancet.com/journals/lane...

[Reinhard in reply to bennevisplace]

Many thanks for this interesting information!