I will be meeting with my hematologist soon for a regularly scheduled appointment. I would like some feedback from the group about evushield. I am a 56 year old, overweight, with bipolar disorder and CLL. I have had 2 shots of the Pfizer vaccine with no evidence of antibodies through lab testing and the immunocompromised dosage of the Moderna shot. I also did not test with antibodies to covid after my 3rd vaccine. I fight a low grade sinus infection almost all the time. I am currently taking imbruvica and have been since diagnosis 5 years ago. I’m unmutatef, 13q, Trisomy 12. Here’s my question. . . should Ii push for evushield, if it is available?
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Health50
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The CLL expert doctors at NY Presbyterian are prescribing Evusheld biospace.com/article/astraz... as a preventive (prophylactic) for their patients with similar issues to yours.
(no detectible antibodies to the vaccines and evidence of high risk of infections). It is in very limited quantities so they are saving it for the most susceptible immune compromised patients.
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It may not be as effective as a treatment after contracting the virus but given before infection it is thought to help reduce the severity of infections and is the only non vaccine preventive available under a EUA in the USA.
The Evusheld literature/trial reports aren’t all that impressive to me. My first choice would be to do nothing and if I got covid I’d get sovrotimab, but that is practically non-existent here at this time. Paxlovid next choice.
Nonetheless, I am trying to get Evusheld; I see where Dr. Furman spoke highly of it, that’s good enough for me.
A question I have is lots of pharmacies are scheduled to get doses, a couple near me. With the requirement when administering Evusheld that the patient be monitored for bad reactions for 1 hour, is that something a pharmacy is equipped and qualified to handle?
Has anyone in the U.S. received Evusheld at a pharmacy?
And if you take Evusheld (2 shots) and still get covid, are you precluded from getting sovrotimab? Or Paxlovid?
I am not a doctor but my bet would be virtually every cll specialist would recommend you get evusheld. Evusheld is created for people like us to protect us from a serious Covid infection. I took my evusheld shots as soon as I could find it and traveled 100 miles to get it. Good luck
HiI also have no antibodies after my first 2 jabs and my first dose of Covid(alpha) while on Obinatuzamab cycles.I was hospitalised briefly for second covid infection(delta) and that was dealt with by monoclonal antibody infusion. 4 weeks later I had my 3 vaccine jab. And 4 weeks after that tested for antibodies again and they were there.... I can't tell yet if they are left from my treatment. I am now on my 3rd Covid Infection and awaiting to be called to receive antivirals. Remember antibodies are only part of the picture as the immune system is complex and other factors provide protection.
Of course you should; unless, for some reason your CLL Specialist is against it. I can't imagine for any reason that your CLL doctor would be against it. In fact I'd be totally shocked if your specialist didn't suggest you do anything possible to get it.
Hi health 50. I have no antibodies either after 2 shots and the booster. My Doctor can’t get his hands on evoshield. He’s supposed to call me today because it stinks being at work knowing I’m not protected. What does your doctor recommend?
I would absolutely push to get the Evusheld, but don't get your hopes up about its availability. Now that you're living in the south, and you have mentioned (in a separate thread) that masks & vaccine use are much lower there, you need to do absolutely everything you can to stay safe.
That said, in vitro studies have shown that Evusheld (cocktail of cilgavimab and tixagevimab) has a reduced neutralizing potency of 200-fold. forbes.com/sites/williamhas...
Evusheld is said to last from 6 to 8 months, and who knows, it might protect against the next emerging variant, even if it's not great against omicron.
I think it's a waiting game until more therapeutic options become available. New (non-mRNA type) vaccines are coming out, which may prompt more people to get vaccinated (the Hotez vax, Novavax, & Walter Reed vax), and maybe Sotrovimab will become more available.
My sanity demands that I have hope. Walk softly, but carry a big N95 mask.
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