Antibodies after third or fourth covid vaccine

[Davidcara]

Hi Everyone,

Wondering if anyone developed initial antibodies, or increased previous antibodies after a third or fourth covid vaccine while on BTK inhibitors such as ibrutinib, or acalabrutinib? Also if you could provide the below information it could be helpful to our community.

1. Which vaccines were administered

2. What was the change in antibody level after the third or fourth dose

3. What BTKi were you on, and was it a reduced dose, or was the dose held prior to vaccination and for how long

4. How long had you been on BTKi therapy prior to your first covid vaccine

5. Were you on any current or recent CLL treatment other than BTK inhibitors

6. Were you on any immune suppressing medication, other than CLL therapy

Sorry I could not format this in a more easily way for responses.

Thank You,

David

[AussieNeil Partner Administrator]

David, I suggest you amend your post to include:-

Which BTK were you on, how long have you been on it (CLL inhibits vaccine effectiveness too, so bonus points for noting your lymphocyte count and spleen/node sizes at vaccination), were you on full or reduced dose, did you have a BTK holiday for your vaccination(s) and did you have an anti-CD20 monoclonal antibody in the 12 months prior to your vaccination?

Neil

[Davidcara]

I will go first

1. Three Pfizer’s

2. No change, all zero

3. Ibrutinib full dose.

4. Started one year prior to initial covid vaccine.

5. Not on ant CLL medication other than ibrutinib

6. Not on any other immune suppressing medication

[Seok in reply to Davidcara]

1. Three Moderna.2. Negative after 2 doses. Positive (4.2) after 3rd dose.

3. First 2 doses while on Acalabrutinib. 3rd dose was on Venetoclax & Ibrutinib.

4. Started Acalabrutinib in March 2020.

5. No other immune suppressant.

[Davidcara in reply to Seok]

Wow, thanks for responding Seok. Glad you made something

[BallyB]

Four Moderna jabs and no antibodies. I am scheduled for Evusheld Thursday.

[Davidcara in reply to BallyB]

Thanks Bally, are you on treatment?

[BallyB in reply to Davidcara]

Yes, acalabrutinib.

[rubberlegs68]

1. 3 moderna full dose vaccines 2. antibodys were 2.6 after 1st, 7.7 after the 2nd, 1100 after third. 140 mg dose of Ibrutinib for 4 years. No other immune suppressing meds. No ibrutinib holiday for vaccines but did stop for 10 days when I contracted covid.

[Davidcara in reply to rubberlegs68]

Thanks rubberlegs

[Eucalyptus22]

3 doses, no antibodies Scheduled for 4th this afternoon.

Been on Acalabrutinib for 15 months.

[Davidcara in reply to Eucalyptus22]

Thanks Eucalyptus

[Davidcara]

If I get enough responses, will try to tally up and post