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Duloxetine or Amitriptyline and sore gums

missmole82 profile image
9 Replies

Hope everyone is well as can be ☺️ I was wondering if anyone on Duloxetine or Amitriptyline experiences sore gums? I went to the dentist yesterday and they think it could be one of the medications that I'm taking, possibly Duloxetine or Amitriptyline. As I've taken both of them together I couldn't really decifer which one it could be but I know it's one of them as it was after starting these that my gums have been so so sore! It's very painful, if I touch some parts of my gums, they feel really bruised and tender. My dentist says there really isn't much build up on my teeth so she doesn't think it's due to plaque build up. She was very resistant to clean my teeth yesterday because of how sore my gums are but I asked if she would do, but hell I'm paying for it now with a part of my gum really really tender.

So my question really is, does anyone else have this issue? And which one do you think the biggest culprit is.

I was told a change in medication may be needed but I'm hesitant to change as both these medications are helping somewhat with my pain and definitely with my sleep. I take the Amitriptyline for neuropathy and the Duloxetine for Fibromyalgia pain and depression.

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9 Replies
012703060610 profile image
012703060610

Wow, I am not alone. I have taken both separately. I am on Cymbalta now as the Amitriptyline caused very dry mouth and bleeding. That was my experience at least. I hate both as they are constipating.

missmole82 profile image
missmole82 in reply to012703060610

That's the thing, when I've looked online about side effects, it says dry mouth and bleeding gums but mine aren't bleeding at all, they are just really sore and tender to the point it's affecting my ability to eat certain foods. It's unbearable. So you think Amitriptyline is the worst culprit?

012703060610 profile image
012703060610 in reply tomissmole82

I don't feel the side effects on Cymbalta! As long as I stay hydrated, I do ok.

missmole82 profile image
missmole82

Thank you for your feedback, I think I may have a word with my GP about the Amitriptyline then, tbh I'm glad it's not the Duloxetine as that's really helping me. The Amitriptyline I am not that bothered with as I was on it alone for a very short while and not long enough to say that one was causing the soreness but it didn't really help with the neuropathy pain when I was on it, although I suppose it could be said I'd not been on it long enough to say that. I did ask my GP if I could come off the Amitriptyline when I was put onto Duloxetine as it does the same thing anyway so I didn't understand the need to stay on it really

Tedsm4lls profile image
Tedsm4lls

I never had sore gums on Amitriptyline 150mgs

davidt2 profile image
davidt2

I have been on Amitriptyline for about 9 months and also have sore gums although not as bad as yours.

missmole82 profile image
missmole82 in reply todavidt2

I'm going to see if I can trial giving Amitriptyline a break, I don't see the need for it anyway when I'm on Duloxetine as they do the exact same things

davidt2 profile image
davidt2

I'm slowly coming off of it, I was on 100 mg, now 40. I have noticed an improvement in my gums, hopefully it will be the same for you.

missmole82 profile image
missmole82 in reply todavidt2

Oh gosh, I'm only on 10mg, imagine if it is that how sore they would be if I was on a higher dose! 😬

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