Tauroursodeoxycholic acid: This was a new one on... - AMN EASIER

AMN EASIER

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Tauroursodeoxycholic acid

monkeybus profile image
26 Replies

This was a new one on me. I only Googled it because I liked the name.

link.springer.com/article/1...

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

ncbi.nlm.nih.gov/pmc/articl...

Alzheimer's, Parkinsons's, Huntington's, ALD, AMN, Ocular disorders.

Impressive stuff for an OTC supplement.

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monkeybus profile image
monkeybus
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26 Replies
bluejadedwho profile image
bluejadedwho

This is very interesting. A lot of medical terms, however through the years I have self-taught through my own research. This is definitely a new idea for me, and sounds very promising.

I'm going to see if it is available at my local health food store. Thanks for sharing.

wilburlois15 profile image
wilburlois15

Well found! That is 2 articles of potential new treatments from December 2016.

monkeybus profile image
monkeybus in reply towilburlois15

I'm positive there is more.

Stop the axonal degeneration, remyelinatiin, upregulate ABCD2.

I'll do a post about Sobetirome in a few hours.

I've been obsessively reading patents. Companies have patented "cures" for AMN. Just existing drugs and supplements repurposed for a new disease.

I'll type it all up later.

wilburlois15 profile image
wilburlois15 in reply tomonkeybus

I read up and bought some TUDCA. It may not do anything but it also doesn't seem to have any side effects so I'm going to give it a go

monkeybus profile image
monkeybus in reply towilburlois15

wilburlois15 , where did you buy? I'll get my credit card out and buy some.

wilburlois15 profile image
wilburlois15 in reply tomonkeybus

Amazon

amazon.co.uk/d/Health-Perso...

monkeybus profile image
monkeybus in reply towilburlois15

Yes, looks good. I always buy bulk powder.

I'm on my phone here, soon as I get to a PC I'll work out the best value.

I'm thinking of ebay.com/itm/151170396125

Yevgenii profile image
Yevgenii in reply towilburlois15

It's been 7 years from this post. Do you still take TUDCA? Have you noticed any improvements?

wilburlois15 profile image
wilburlois15 in reply toYevgenii

I had to stop in 2018 because I went on to the MIN-102 trial. I didn't notice any difference but then again, MIN-102 also hasn't changed anything!

tieaknot profile image
tieaknot

Thank you for all the time and effort you put into researching and especially for sharing this info! I truly believe the sharing here is what will bring us the best results and hopefully a cure in the future!

monmon profile image
monmon

Impressive speed! That was was only published on 21/12/16! Thank you Monkeybus.

deengo profile image
deengo

I just bought some I'll give it a try also. It was on back ordered on a lot of sites.

Yevgenii profile image
Yevgenii in reply todeengo

It's been 7 years from this post. Do you still take TUDCA? Have you noticed any improvements?

monkeybus profile image
monkeybus

Maybe I've started a revolution. Biotin was sold out for a while when the remyelinatiin news was announced.

bluejadedwho profile image
bluejadedwho

Any updates on the TUDCA? This seems like one of the most promising things I've seen yet.

monkeybus profile image
monkeybus

I ordered from Ebay (that renowned purveyor of nutraaceuticals).

Forgot all about it, hasn't arrived yet.

I'll chase it up ASAP

bluejadedwho profile image
bluejadedwho

I've started taking the TUDCA. I have been reading the study, and cannot determine what dose they used in the mice. Then perhaps we can figure out a dose for humans relative to weight. Does anyone have any ideas?

This seems amazingly promising. It appears that mitochondrial damage as present in adrenomyeloneuropathy is also present in many neurological conditions.

monkeybus profile image
monkeybus in reply tobluejadedwho

@bluejadedwho, I've been banging on about mitochondrial damage for what seems like years now.

Nice to see someone else reference it.

I'll post later about mitochondrial nutrients. Something in this, for sure.

bluejadedwho profile image
bluejadedwho

Any updates on TUDCA? I only took it for two weeks then stopped for some reason. I’ve just started a week ago again. I’m taking between 1000 and 1500 mg a day. I still can’t figure out dosage based on the study. Has anyone been able to figure it out? I have a question into the doctor at Kennedy Krieger, hoping he can help me with that.

bluejadedwho profile image
bluejadedwho in reply tobluejadedwho

Any updates on TUDCA? I only took it for two weeks then stopped for some reason. I’ve just started a week ago again. I’m taking between 1000 and 1500 mg a day. I still can’t figure out dosage based on the study. Has anyone been able to figure it out? I have a question into the doctor at Kennedy Krieger, hoping he can help me with that.

monkeybus profile image
monkeybus in reply tobluejadedwho

I forgot all about TUDCA.

I'll post up about it later today.

I'll say one thing, it costs a fortune.

bluejadedwho profile image
bluejadedwho in reply tomonkeybus

It all depends on what the dose should be. I have read the study from Spain over and over and still cannot figure out a dose.

It is about $50 a bottle for 60 caps. At 1500mg a day, (I read that the upper safe limit is around 1700mg/day) we are looking at $150/month.

If this helps in any significant way, this is worth it. I have been on it steady for 1 month. In the study, the mice were treated for 3-4 months and then improvements were noted. They also discussed the anti-oxidant cocktail of vitamin E, alpha lapoic acid and N-acetylcysteine. They did a study on this a while back before the TUDCA. I don’t know if this needs to be used in conjunction to repair free radical damage or not. I wish there was more guidance for things like this.

monkeybus profile image
monkeybus

clinicaltrials.gov/ct2/show...

1 gram, twice a day.

I saw the study you talk about. What do I know? But the antioxidants have been proven to work in mice, sadly not for me.

I am ordering more TUDCA right now, I'll do the 2 grams per day regimen. Plus antioxidants.

bluejadedwho profile image
bluejadedwho in reply tomonkeybus

Oh man, 2 grams. Unfortunately, I live in Canada, and it’s not available here. I have to order from the states. So with shipping and the conversion rate it’s going to be about $200 a month. However, as I said before if it works then it’s all worth it. Is this study happening right now that you reference, or has it concluded? Do you know how they came up with the 2 g per day?

deengo profile image
deengo

I've been taking the TUDCA for awhile now. I'm way underdosing compared to these numbers.

Also I've been taking the antioxidant cocktail since they began that study and believe it helps. I was taking it for about 6 months and wasn't sure if it was working. I stopped for about 3 months and felt worse and started again and haven't stopped.

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