Wait or start docetaxel?

[AllenMarco]

Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT or Tc99 scan supports the findings of the PSMA scan I can wait, as long as I have a scan every 3 months. He feels that there can be a 1-1.5 year lag time between the positive PSMA scan and positivity on a CT and that there are QOL reasons to wait.

Thoughts and opinions?

Thank you

[KocoPr]

Sorry to hear about your Daro failure and previous enza failure.

I couldn’t get a reading from your bio how long were you on daro before failure?

I also haven’t seen and genetics testing.

[AllenMarco in reply to KocoPr]

Enzalutamide worked well as sole agent 3 years as part of the NIH trial. Darolutamide worked for 3 years before adding Orgovyx early this year. MO said that my genetic markers show some degree of resistance to ADT.

[KocoPr in reply to AllenMarco]

I don’t mean to sound pushy but you need to take charge and know your genetic markers and all your numbers. You can’t put everything on your doctor who only sees you once a quarter and he probably sees 10 patients a day x maybe 4 days a week x 12 weeks and that adds up to you being one of 60 patients and then you only get a half hour with him.

You can use the hospital’s portal to look at all your numbers/reports/visit summaries etc. i wish you all the best and fight on

[j-o-h-n in reply to KocoPr]

1/2 hour???......... Check your watch.........and/or the Doctor's watch....

Mickey's (start) little hand is on the 12 and (end) his big hand is on the 3.........Okay next PaYtient.

Note: I wish to offer my apologies if I offended anyone regarding my so-called humor about "race" or "misogyny". To me, humor is boundless and since we entered this word crying, I thought it would be a good idea to exit laughing.

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 12/17/2023 6:36 PM EST

[Hidden in reply to j-o-h-n]

Spoken like a true racist. You will never change.

[maley2711 in reply to KocoPr]

He should be his own Doc?

[Tall_Allen]

I think using Xofigo earlier may have some benefit. The combo with docetaxel allows reduction in the chemo dose:

prostatecancer.news/2021/02...

[msnik in reply to Tall_Allen]

hello Tall Allen....the link you provided says ".....So far, it is only FDA-approved as a monotherapy,"

are you implying that he could get someone to prescribe the combo for him outside of the

trial? if he does the trial he has only a fifty/fifty chance of getting the combo.

Thank you to all for sharing your knowledge. good luck.

[Tall_Allen in reply to msnik]

Everyone gets the combo at the trial at Tufts, Henry Ford, and Ohio State.

clinicaltrials.gov/study/NC...

[msnik in reply to Tall_Allen]

Thank you.

[louschu]

Chemo kills cancer. The two drugs you are on suppress cancer. My chemo went ok and got rid of soft tissue cancer. I still 6 years later have it in my bones. But I'm still here and getting lu177