PALB2 genetic defect-Lynparza

[Azores1]

I have PALB2 genetic defect. Just completed six cycles of Taxotere as part of triple therapy (chemo, Nubeqa and ADT) for about 20 Mets (PSMA scan) mostly skeletal (no organs). Only four Mets still lit up on PSMA scan after four cycles of chemo/Lupron/Nubeqa. Next PSMA scan in Jan. 2024. Oncologist recommends starting Lynparza in a month or two after side effects of chemo mitigate (edema, fatigue, blood clots in surface vessels in arms). My question: has anyone here taken Lynparza and what side effects? I still work full time and worked through chemo. Want to continue working. I am 75 y/o. Thank you all for your contributions to HU.

[mrscruffy]

just started 1/2 dose this week. I get pretty bad indigestion if I don't take with food

[DrFeeelgood]

Been taking for 2 years. When I first started it made me nauseated in the morning, but if you eat first and then take it you should be fine. Take 300 mg in morning, 300 mg at night. Don’t really notice any other side effects. Also take Lupron, Casodex, Xytega. Keep fighting!

[Azores1 in reply to DrFeeelgood]

Thank you!

[Azores1 in reply to Azores1]

How is it working for you in terms of disease control?

[j-o-h-n]

Note: Their are tons and tons of posts with the meds " Lynparza" listed as part of the topic or in the text. Just do a find on H.U. history to find them.

Meanwhile, would you be kind enough to detail your bio on you bio home page. All info is voluntary but it helps you and helps us too. Thank you!

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 11/12/2023 7:17 PM EST

[Azores1 in reply to j-o-h-n]

Will update tomorrow and thanks!

[j-o-h-n in reply to Azores1]

Thank you Senor..........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 11/18/2023 12:26 PM EST