Cabazitaxel after reaction with Docetaxel

[Szdnizam3]

Hello everyone,

During initial treatments my father was given docetaxel chemotherapy, but within minutes of infusion he experienced a severe reaction and fainted. Since then, he has been on hormone therapy and oral drugs like Nubeqa and Zytiga.

As his PSA is going up, his oncologist wants to try giving chemotherapy again but with cabazitaxel.

Has anyone else experienced a similar reaction with docetaxel and were able to successfully undergo a second attempt with cabazitaxel? I’d greatly appreciate any insights or advice.

Thank you!

[God_Loves_Me]

I know one person reported similar side effects on this group or other group. I think he did benadryl iv and tried docetaxel again. It fixed his side effects.

[NemoHic in reply to God_Loves_Me]

You may be thinking of me. I had a severe hypersensitivity reaction a few minutes into the first docetaxel infusion. They pumped me up with lots more dexamethasone and benadryl to end it and started up the docetaxel again at half delivery rate (but still full dose) around an hour later. All subsequent infusions were at half rate and I didn't have any more problems. Everything I've seen says you get desensitized after the first reaction but I wouldn't know if that carries over from docetaxel to cabazitaxel. (They are both similar taxanes so maybe?) Maybe OP can ask for extra dexamethasone and benadryl along with a reduced delivery rate for her father?

[God_Loves_Me in reply to NemoHic]

Yes , I was thinking about you. Thank you

[PChater]

I had a very similar reaction to Docetaxel. My oncologist increased my premeds and slowed my next infusion to two hours. I reacted again within 5 minutes of my second infusion and the infusion was stopped. I next had 6 Pluvicto treatments with mixed results. My oncologist recommended Cabzitaxel and I was able to get 6 infusions with no reactions. Good luck.

[4tunate1]

My story is similar. I lasted 2 minutes and 7cc on my first attempt with Docetaxel as part of an NIH trial. They did not re-attempt after getting me out of the situation dex and bendadryl. They discussed with my local MO and decided that since I'm responding extremely well to Lupron/Abi, not to mess with chemo. Perhaps the silver lining to all of this.

I offered to try again with the pre-treatments but NIH and my MO stuck to their plan. I don't think NIH wanted to be bothered with me as my reaction would probably interfere with their data. Just my opinion.

Regardless, if your father and his health are up to another chemo challenge, that's great. Best of luck to you both!

[Szdnizam3]

Thank you everyone for sharing your experiences.

They said that they will be giving Dexamethasone, Benadryl, Pepcid, ondansetron before infusion to avoid rejection.

Hope it works this time.