Looking for suggestion of clinical trials for mCRPC

[Cmdrdata]

I have had SBRT (2007), Chemotherapy (2010/2011), ADT using Casodex/Lupron/Zytiga (2012-Current). Interested in joining trials that involve PARP inihibitors, immunotherapy, or other new/novel therapies. Can any of you suggest trials currently accepting candidates. My PSA was undetectable (<0.01) for about 5 years, but in the last 4 quarters it began to creep up. Latest PSA this past week is 1.01, with no obvious symptoms at this point. Last MRI/CT scan 6 months ago was negative. Thanks in advance. Prefer Texas location if possible.

[Tall_Allen]

MD Anderson probably has more clinical trials than anyone. Maybe get a consult with Paul Corn to discuss. Or Oliver Sartor at Tulane.

[kklott01]

I am currently in a trial at MD Anderson that includes Cabazitaxel, Carboplatin, Cetrelimab and Niraparib. I have been in this trial for 21 months. My M.O. is Dr. Submit Subudhi.

See more info on clinical trials.com, the NCT is NCT04592237.

[Cmdrdata in reply to kklott01]

Thanks. I’ve emailed the principal investigator asking for more questions with regards to my inclusion/exclusion eligibility. I I’ve in the Dallas area. In the past I have traveled to Houston every 2-3 months to see my favorite Oncologist/Researcher. Unfortunately he passed way a few years ago. Also investigating ODM-208

[MateoBeach]

You don’t mention any somatic genetic nor IHC analysis that can guide targeting trials such as PARP, DDR and such. Do you have PSMA PET scan recently to look for a met accessible for biopsy? And for suitability for Pluvicto?

A few rounds of BAT may restore sensitivity to the Zytiga or other AAR drug. You might need more data, Commander.

[Cmdrdata in reply to MateoBeach]

Thanks. I had a genetic mutation screening 2+ years ago, and there were no genetic mutations that may cause PC. BRCA1/2 and HER1/2 also negative. Last year I had CT/MRI/Bone scans and there are detectable mass. My Onc is reluctant to send me to a facility that have PSMA scan, not available at his facility.

[HopingForTheBest1]

Go to clinicaltrials.gov for a comprehensive list.

[Fightinghard]

Not trials but Provenge might help you. Then LU 177 but might need a trial participation depending on you specifics

MO Drs at UT Dallas should be familiar with both and could guide you.