I’m a 74 year old male with advanced prostate cancer. I was diagnosed with metastatic disease in 03/2010. My gleason score was 9 and my cancer was said to be “very aggressive” with scans showing mets in the right ribs and the right hip. I was entered into the Chaarted Study and received taxotere and lupron. My PSA quickly dropped from 7 to 0.1 although I had to withdraw from the taxotere (chemo) halfway through the treatment cycle due to the onset of chemo induced neuropathy in my feet and legs which persists to this day. Owwie! All radiographic evidence of metastasis promptly disappeared. In 2012 my PSA rose again until peaking @17. At that point I also became unable to urinate as the cancer had obstructed the urethra. I was given a modified TUR using laser surgery which fixed that problem and I was also placed on abiriterone acetate ( Zytiga). My PSA very quickly dropped back to 0.1 where it remained until early 2017. Since then it has been steadily climbing until reaching 8.4 last month (Dec 2017). Scans remain clear. Now the docs must decide what to do next and it looks like Xtandi or Keytruda (immunotherapy) off study. Neither is likely to be as effective as the Zytiga. The other option is to look at clinical trials of which there are many in the large metro area I live in. I meet with my medonc next week. Any advice?