Can too much denosumab cause heart problems?

[inHishand]

My husband has been on 6 mo. Prolia injections since 2017. Recently, he decided to have treatment closer to home, as he was to receive docetaxel. His heart health has always been excellent. Upon receiving first chemo treatment on 7/19, he was also given a one month injection of Xgeva, although he was not due for any injection until October 1. Could this be the cause of newly diagnosed heart problems? Hospitalized at end of July for perforated duodenal ulcer and experienced some vtac episodes. Stress test did not show any significant problems; however, a small blockage may be present. Delay in any heart cath procedure until he recovers from abdominal surgery. Thanks for your responses.

[Tall_Allen]

It's not a known adverse reaction to denosumab.

[inHishand in reply to Tall_Allen]

However, afib is a known reaction. Correct?

[Tall_Allen in reply to inHishand]

I have not heard that and don't see it on the prescribing info. Where did you read that?

[inHishand in reply to Tall_Allen]

Drugs.com and rxlist.com

[Tall_Allen in reply to inHishand]

It's not in the prescribing info or in epocrates:

online.epocrates.com/drugs/...

And I don't see it in any of the clinical trials of it that I have. I think drugs.com and rxlist.com may be wrong.

[inHishand in reply to Tall_Allen]

Thanks for your response, TA.

[StayPositive1]

Very cool photo, can you tell us what we’re looking at here please, Alaskan glaciers? Sorry, that I can’t help with your question

[inHishand in reply to StayPositive1]

Glacier in southern Argentina known as Perito Moreno. Photo is dated…about 1989.

[MateoBeach]

You may or not have been advised to take supplemental calcium and possibly vitamin D when started on denosumab? It does increase calcium uptake especially initially so this should be monitored. The reason I mention it is that active vitamin D3 is reputed to also increase calcium uptake into arteries (atherosclerotic plaques). This can be prevented by taking Vitamin K-2 along with vitamin D3. Vitamin D levels should be monitored along with calcium routinely if taking higher dosages. Just a thought to consider. The negative stress test is reassuring.

[inHishand in reply to MateoBeach]

Thanks, Mateo, for the reference to Vitamin K-2. Only thing recommended to him re: denosumab has been calcium and D3 daily. He was discharged from hospital (after surgery for perforated ulcer) with, among other prescriptions, a once a week capsule of D3 @ 50,000 iu, as he has a significant D3 deficiency. Maybe this deficiency is blessing in disguise if it can cause calcium uptake into arteries....must be a fine balance. He will inquire about using K-2 when he sees cardiologist....for the first time ever in his 84 years.

[Nfler in reply to inHishand]

One can always incorporate ivermectin in their protocol safely and in lieu of in a lot of cases, good luck 🍀…😊😇😇