Prostrate cell division

[Poollover]

Does age effect the speed at which prostate cancer cells divide? There are many factors that affect cell division, but I'm interested in the effect of age. Perhaps not a question that cannot be answered. I'm now 87, stage 4, Gleason 9 on Orgovyx, Zytiga and generally doing okay and concerned for how long these drugs will continue to work. I have been on these drugs for about a year.

[Tall_Allen]

In general, prostate cancer spreads faster with age.

ncbi.nlm.nih.gov/pmc/articl...

[m1946 in reply to Tall_Allen]

I was always under the impression that with age and the lack of testorone prostate cancer did not have such an impact as if one was younger?

[Tall_Allen in reply to m1946]

Your impression was incorrect.

[Jewelrylady in reply to m1946]

This study is comparing younger men to older men who had a prostatectomy. Did you have this?

[m1946 in reply to Jewelrylady]

NoJust Brachytherapy 2011 and intense radioactive beam therapy to a rogue lymph node last year. At the age of 78 I hope & wish that my next PSA reading will be well within acceptable limits!!!

[Jewelrylady in reply to m1946]

I hope so, too🤞

[Worked_the_World]

This is only speculation, but statistically we older folks (I an 85) might have longer times to develop more advanced cancers. Perhaps the conclusions in the study are influenced by that.

None the less, Poollover, your courage is pretty good proof against this condition. An earlier patient at church made a good point. This prostate cancer is only an attack out there. In no way do we ever take ownership and call it our cancer.

[Poollover in reply to Worked_the_World]

Thanks for your encouragement. Often, I feel like just sitting, but try to not give into fatigue and fight through it. I'm still able to work and play pool 6 days a week.

[Yokohama2023 in reply to Poollover]

Agree your positivity is infectious.. keep enjoying life

[Mgtd in reply to Poollover]

way to hustle!

[Sagewiz in reply to Poollover]

The fatigue is my biggest issue as well. I have finally been getting to the gym 6 days a week and pushing through it as much as I can, but I still have profound bouts of fatigue that come and go.

[Poollover in reply to Sagewiz]

+

Yes, sometimes I too feal like sitting in front of the TV and eating ice cream.

[Worked_the_World]

That is just what I meant. My urologist called me last October after a biopsy. He said he loves giving good. Unfortunately, in my case he said I had an extremely aggressive Gleason stage 9 prostate cancer. Is did not show signs s of metastasis. I've tried to give this SOB hell. I have taken Orgovyx since Feb. 29. My first prescription cost $889.00 for 30 pills The practice got me a grant since for a year.

The Doc said last month he liked my positive attitude. I had SBRT at the end of April.

I have doubled down on banging the piano at church on Sundays, hit the gym a time or two a week, cooking dinner for my spouse of 58 years as she descends into dementia, I write novels as well. This pushes the cancer down to priority five or so. My MO said I might be in remission. I had my six-week PSA test today. Signs are decent, but I cannot take such a shock again, so am skeptical in the extreme. I will receive results tomorrow.

Like you, I have had muscle and joint pain, and still do. Depression is frequent, mental confusion is continuous, coordination comes and goes.

Here is my every day. Up at four or five am. Walk dog to see the sunrise. Give thanks to God and the Great Spirit for the day given. I promise to make the best of it possible. I would feel disingenuous to ask for more. I will give thanks for each one that comes and will fight for every one that comes my way.

You, my friend, are in this with me. Let's walk this journey together. We can chat privately if you want.

Apologies for this long post.

[Tinkudi in reply to Worked_the_World]

very well said 😊🤗

[Tommyj2 in reply to Worked_the_World]

You can SAY that your prostate ca is # 5 on your priority list but it has a way of bullying it’s way to the top without your permission……hope you are paying close attention.

[Poollover in reply to Tommyj2]

Yes, of course, it's omnipresent always.

[Worked_the_World in reply to Tommyj2]

Tommy, You are correct. My comment really focuses on my attitude toward this condition, not my attention.

I am now twelve weeks past a five-session SBRT. My medical oncologist recommended a PSA test for three months, as in right now. However, I talked her into a PSA test every six weeks for a half a year. I am more interested in the trend than the absolute level at this point. My PSA at fiducial insertion was 0.9. It was 0.7 right after SBRT. was 0.3 six weeks after SBRT. It is now 0.2 at twelve weeks. I was hoping for a lower value, but this is okay.

My activities are my efforts to maintain a positive attitude through the muscle and joint pain, mental confusion, occasional loss of coordination, the love affair with the toilet for my urination, my depression, my muscle loss even with exercise, and other symptoms I cannot remember.

My Dad died of a heart attack at 52 years old. I have made it to 85, so have an extra 33 years. I have tried to use them well. Each day counts as a blessing. I begin with my dog on a walk to watch the sun break the eastern horizon in a glorious display. I give thanks to God and the Great Spirit and ask for no more. I fervently hope for many more.

Thanks for your reply.

[Poollover in reply to Worked_the_World]

In many ways you sound like my twain: up at 5-AM, core exercises, hot tub at 7-AM, breakfast, out with my Belgium Shepard to the dog park where she loves to catch frisbees, and so on. I have 3 sons, who worry about me, but I tell them I'm still enjoying life and have had a great life, on like their wonderful mother, who was cheated, didn't see 60 -- breast cancer. Maybe we should carry on in private; why bother others with this stuff. Mental confusion: I couldn't stand in front of a class again. They would think that their professor had lost it; maybe they thought that anyway.

Where do you live? I live on Cape Cod.

[j-o-h-n]

Remember, you're as old as the woman you feel....

Good Luck, Good Health and Good Humor.

j-o-h-n

[MoonRocket in reply to j-o-h-n]

Very funny j-o-h-n. Now this woman has to get ready for work.

[j-o-h-n in reply to MoonRocket]

Well it's a good way for her to start off her day (and yours too)........

Good Luck, Good Health and Good Humor.

j-o-h-n

[Poollover in reply to j-o-h-n]

"The human animal is the only animal that blushes or needs to." Twain

[j-o-h-n in reply to Poollover]

I know from experience..........my ex-wife is a real (and a mean) in-human animal......

Good Luck, Good Health and Good Humor.

j-o-h-n

[Worked_the_World in reply to j-o-h-n]

After all this bullshit the medical profession has inflicted on me over the past months, I sure as fuck am no longer a man.

However, appearances can be deceiving. I am returning to my roots. On top of a ten-gallon cowboy hat, I have bought western shirts, blue jeans, a wide leather belt, and am looking for an obscene silver belt buckle. I expect my cowboy boots will arrive next week.

Now to perfect my cowboy swagger.

I actually did work on a ranch, but hustled bales of hay, not cows. Cowboy sounds better than baleboy.

See ya on the trail, pard.

[Poollover in reply to Worked_the_World]

It's now 4:41 AM, EST. thanks for the laugh.

[j-o-h-n in reply to Worked_the_World]

Remember: Save a horse and ride a cowboy....

Good Luck, Good Health and Good Humor.

j-o-h-n