CAR-T follow-up at City of Hope for Prostate Cancer to Bone

[abmicro]

They pulled me back into City of Hope hospital with high Iron levels after a CAR-T discharge from hospital.

Treatment started working, lowering my PSA from 60 to 50, but high Ferritin (Iron) hit 6000 indicated t-cells could start attacking non-cancer places it shouldn't attack. Dr calmed it down with an IV10 of dexamethasone and another drug. Clinical Trial central almost recommended killing all the T-cells and pulling the plug on my COH trial. Glad they didnt do that. This is my only hope. I have no other options.

Blood counts still very low, and if the dont turn the corner soon, they will give me a pint of blood.

Urine test showed an infection so IV is running an antibiotic. Wife is waiting for me to get out of hospital again. She is waiting at a local hotel in Arcadia, CA.

Have a little less pain now. I think I will get a mild response when this treatment gets done working. I would compare the response similar to Lu177, but without the radiation and bone side effects. Wont get a full remission that will put me back on the dance floor, but I will get a small life extension from metastatic prostate cancer to bone, (hips, spine, and ribs). Every treatment helps, even if just a little at this point.

I appreciate the team of health unlocked warriors thinking about me.

[GP24]

I hope you will get a very significant remission! Thank you for providing information about the CAR-T trial. Very few patients are included - as far as I know.

[Tall_Allen]

Glad to hear you made it through that crisis. CAR-T is very risky, but when it works, it works well. I hope it works well for you.

[abmicro in reply to Tall_Allen]

Thanks. Hope so. After 19 years fighting this beast, this is the last treatment option I have--better a risky one than let the cancer run amuck, lose the battle, and send me to hospice.

[NWLiving]

High iron? Confused about that. Thanks for posting. Sounds like a scary time and a good team. I’m sure she is worried for you.

[keepinon]

I hope you are able to continue the trial.Best of luck to you! And thanks for participating!

[TJGuy]

Can you elaborate as to any specific modifications they are performing on your T-Cells to direct them to your cancer?

Are they using your cells or generic cells for this process.

Is this a case of finding a few if your T-Cells that have the most interest in and are the most robust in attacking the cancer.

Selecting those and growing and reinjecting?

Are they adding manmade receptors to your T-cells to lock onto the cancer as well?

Thanks

[andrew61]

What is your neutrophil count?