Anti-proliferative effect of Cannabid... - Advanced Prostate...

Advanced Prostate Cancer

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Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3

NewPotatoCaboose profile image

More on CBD and prostate cancer

Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3 is mediated by apoptotic cell death, NF?B activation, increased oxidative stress, and lower reduced glutathione status

pubmed.ncbi.nlm.nih.gov/377...

Abstract

Prostate cancer is the second most frequent cancer diagnosed in men in the world today. Almost all prostate cancers are adenocarcinomas and develop from gland cells. We used the PC3 prostate cancer cell line, which is well studied and derived from a bone metastasis of a grade IV prostatic adenocarcinoma. Cannabidiol (CBD), a major non-psychoactive constituent of cannabis, is a cannabinoid with anti-tumor properties but its effects on prostate cancer cells are not studied in detail. Here, we found cannabidiol decreased prostate cancer cell (PC3) viability up to 37.25% and induced apoptotic cell death in a time and dose-dependent manner. We found that CBD activated the caspases 3/7 pathways and increased DNA fragmentation. Furthermore, we observed an increase of pro-apoptotic genes Bax, an increased level of reactive oxygen species, lower reduced glutathione level, and altered mitochondrial potential in response to CBD treatment leading to lower cellular ATP. Overall, our results suggest that CBD may be effective against prostate cancer cells.

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11 Replies
Maxone73 profile image
Maxone73

normally I would say “cell lines and in vivo does not mean it works on humans” (unluckily)….but when we talk about cbd and thc…I feel I am…let’s say…way less rigorous! 😜😜😜

Nfler profile image
Nfler

it’s seems to b working for me, I do1-2ml/day along w ivermectin 2-4/days/week and psa continues to drop readily…def worth a try

Maxone73 profile image
Maxone73 in reply toNfler

What concentration?? 😊

Nfler profile image
Nfler in reply toMaxone73

Ivm at 12 mg/day 4/days a week.

Cbd at 1-2 ml/day 6 days/week

Maxone73 profile image
Maxone73 in reply toNfler

Yes, ok about ml but concentration? My oil here is 275mg per 10ml but there are different concentrations. Many express them just as percentage, like 10% cbd oil. I could also grow some plants in spring but I would prefer not smoking it!

Nfler profile image
Nfler in reply toMaxone73

Oh sorry, it’s500mg/10 ml, I get it from Lazarus naturals out of Oregon, high quality…

Maxone73 profile image
Maxone73 in reply toNfler

I am not even sure I can find that concentration in shops here in Europe, but I will check!

Nfler profile image
Nfler in reply toMaxone73

Well order it from Lazarus, they give a 60% discount to low income and their the highest quality I found this far

Maxone73 profile image
Maxone73 in reply toNfler

I will look into it, not sure that the customs would let me import it but you never know

NewPotatoCaboose profile image
NewPotatoCaboose in reply toNfler

Lazarus is great! Been ordering from them for several years.

dhccpa profile image
dhccpa in reply toNfler

How many mg of ivermectin per day?

Never mind, I saw it.

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