Akkermansia - how to increase levels in the gut microbiome

[pjoshea13]

This is a follow-on from my Akkermansia post.

1] while Akkermansia is not yet a common probiotic, Bifidobacterium is.

- 2019, Spain:

Bifidobacterium animalis subsp. lactis (Ba8145) "ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index ...versus its baseline. Changes versus the placebo group reached significance ... after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group .... Diastolic blood pressure and HOMA index decreased ... Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight"

2] Sodium Butyrate and Inulin

- 2017, Iran

"There was a significant increase in A. muciniphila percent change in inulin and butyrate supplemented groups .... Also hs-CRP, MDA and diastolic blood pressure levels decreased significantly in these groups.."

3] Polyphenols

3.1] Berberine / Metformin

3.2] Green Tea:

3.3] Blackberry leaf & fruit extract:

3.4] Cranberry extract:

3.5] Capsaicin:

3.6] Pomegranate:

3.7] Curcumin:

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/302...

[2] ncbi.nlm.nih.gov/pmc/articl...

[3.1a] pubmed.ncbi.nlm.nih.gov/338...

[3.1b] pubmed.ncbi.nlm.nih.gov/292...

[3.1c] pubmed.ncbi.nlm.nih.gov/279...

[3,2] pubmed.ncbi.nlm.nih.gov/325...

[3.3] pubmed.ncbi.nlm.nih.gov/317...

[3.4a] frontiersin.org/articles/10...

[3.4b] pubmed.ncbi.nlm.nih.gov/269...

[3.4c] pubmed.ncbi.nlm.nih.gov/250...

[3.5] ncbi.nlm.nih.gov/pmc/articl...

[3.6] pubmed.ncbi.nlm.nih.gov/279...

[3.7] pubmed.ncbi.nlm.nih.gov/339...

[Hidden]

Hi Patrick, do you use a probiotic and, if so, which one?Thanks, Russ

[pjoshea13 in reply to Hidden]

I am a long-term user of low-dose Minocycline (every other night) & double-up on probiotics every morning.

For years I went for the expensive refrigerated brands - latterly, one of the Dr. Perlmutter-formulated "Garden of Life" concoctions. When the pandemic hit, I switched to mail-order brands that did not require refrigeration.

At the moment I am using:

swansonvitamins.com/swanson...

I am going to quit Minocycline & allow Akkermansia to flourish. I will stay with the Swanson product for now.

Best, -Patrick

[Hidden in reply to pjoshea13]

Thanks. I bought 4 bottles on amazon. Good price. amazon.com/Swanson-Probioti...

[TheTopBanana in reply to Hidden]

RSH1, what are your opinion on this supplement?

pendulumlife.com

As I wrote in another post: Since I live in Sweden it is very (!) expensive, and difficult, to get a hold on. Yet if there is Akkermansia to get a hold on for my father, I'm willing to try. Thankful for any thoughts!

[Hidden in reply to TheTopBanana]

Trial results look good. But there are lots of tricks that can be played with trials (I'm not implying that they misrepresented their results - I'm only stating the need for healthy skepticism). Thanks for the link. I might try this. Expensive but shouldn't be too hard to test out the results. Do an a1c blood test before starting, take this for a month and test again. Also monitor blood glucose. You could use a Dexcom or another continuous monitor but a day by day fasting BG test should probably suffice.

I don't mind ponying up and testing it and then letting you know what the results were (it would be N of 1 and certainly not conclusive but I think perhaps would give more insight instead of relying on a manufacturer-sponsored study).

[MateoBeach in reply to pjoshea13]

The ultra potency has much higher CFUs count any twice the fos. swansonvitamins.com/swanson...

[TheTopBanana in reply to MateoBeach]

Hello MateoBeach! Could you say that sentence again put simplify it for a Swedish person..?

[MateoBeach in reply to TheTopBanana]

CFUs means colony forming units, an assay for how many active probiotic bacteria are in a dose. The higher, up to 100 billion, the more potent. Probably more important initially than for maintenance. FOS is fructose oligosaccharides, short chain soluble fiber similar to inulin, that feed and support the healthy bacteria.

[MateoBeach]

Thank you Patrick. Very thorough as usual. You are right I could not find a commercial product with akkermansia m. But bifidobacterum sp. Yes. Appears that, along with inulin and possibly a little butyrate will support it. I also have foregone the anti inflammatory benefits of doxycycline/ minocyclin in favor of preserving gut microbiome

[fish7days]

Pendulum makes a probiotic that contains it but rather expensive.

[MateoBeach]

I may do one month of the Pendulum product to establish akkermansia and then use the Swanson or similar for ongoing use. Chicory as inulin supplement?

[Peppertree602]

anyone heard of this one? expensive but from what I read (I am novice at best) it seems very good. thisisorenda.com/orenda-ult...