Gut microbiome and prostate cancer

The U.S. government is overseeing a dozen or so RCTs pertaining to gut microbiome and prostate cancer. A few of them:

To Investigate the Role of Gut Microbiome in ADT Related Metabolic Changes in Prostate Cancer Patients - Full Text View - ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

Evaluation of Gut Microbiome in Patients With Prostate Cancer - Full Text View - ClinicalTrials.gov (I found an NIH writeup of the results and nothing striking was found)

clinicaltrials.gov/ct2/show...

Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer - Full Text View - ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

Intestinal Microbiota in Prostate Cancer Patients as a Biomarker for Radiation-INduced Toxicity (IMPRINT) - Full Text View - ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

[fmenninger]

should we be eating more kimchee and sauerkraut?

[Hidden in reply to fmenninger]

I don't know if we have the answer to that. Zytiga and Metformin "might" increase some potentially beneficial bacteria. As pjoshua posted, standard ADT might increase some potentially harmful bacteria (Zytiga is an interesting exception - something to do with the mechanism of action).

I take Zytiga and had my gut biome measured with a biomesight.com/ test.

My beneficial bacteria are supposedly 20x the average. Verrucomicrobia phylum (includes akkermansia).

But I do not take Zytiga to change my gut biome. I take it to block cyp17 (standard therapeutic use).

Until we know more about the microbiome, it makes sense to me to eat plenty of fiber and maybe add some probiotics like the ones you mentioned. I do find it interesting that there are a few dozen RCTs in progress. Hopefully, this is an area where the smoke comes from a fire.

25. Akkermansia is speculated to be a PCa beneficial gut bacteria: Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotic in the gut, evidence from dietary intervention studies - PMC

ncbi.nlm.nih.gov/pmc/articl...

26. Akkermansia is speculated to be a PCa beneficial gut bacteria: Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients | Nature Communications

nature.com/articles/s41467-...

[Scout4answers in reply to Hidden]

any reason you picked biomesight?

[Hidden in reply to Scout4answers]

Not really. I read about it in an article. It was only a couple hundred bucks so I didn't bother looking around. And I figured that the only way it would be actionable is if something was way off.

[Hidden in reply to fmenninger]

Hec yah! Both fantastic!