Please shoot holes in this plan. - Advanced Prostate...

Advanced Prostate Cancer

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Please shoot holes in this plan.

Crabcrushe profile image
12 Replies

Dx Stage 4 Gl 9 bone mets only, PSA 41, 6 cy. docataxel, leuprolide since 10/16, PSA 1.2, doubled in a year, added bicalutamide, doubled in a year, swapped out Casodex for enzalutamide, roughly half way through the Provenge thang.

Plan to pause Lupron/Xtandi for 2 quarters, receive SBRT in Sep, cavitaxel w/carboplatin/resume Lupron/Xtandi in Oct with Avodart.

The rationale is that the stinking crab cells are adding the adaptive gene to their long, chromosomal "tail" (roughly) annually (for me), a met or two springs up each double (detectable mets). I picture the process as a tree with "blight spots" as the mets, which are dormant during most of the treatment phase prior to the cell's adaptation/conversion. So, I'm thinking to use enough Grays to render the met sites and gland peranently dormant, while using max tolerable dosages of the ADT(s) for 9 months only. Then I take a vaycay and repeat the cycle with new ADT' s each time. The breaks give my organs a rest, I can regain top physical conditioning, and the little SOB's will barely have time to add on to their tails when they get waylaid by a new weapon (apalutamide, et al.) each iteration.

Nous Defions

Crabcrusher

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Crabcrushe
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Crabcrushe profile image
Crabcrushe

Where's the edit button?

in reply to Crabcrushe

See the 'v' after More? Hit that to edit.

Crabcrushe profile image
Crabcrushe in reply to

Thanks!

Crabcrushe profile image
Crabcrushe

My intent is to receive feedback in the areas in which I' m ignorant or have little experience by people who got the T shirt. Don't t roll over on me now, m'amigo; gonna present this puppy on 3/18.

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Tall_Allen profile image
Tall_Allen

I'm not sure I understand, but I think it's important that you have maximum hormone therapy starting before and continuing through SBRT. A better way to visualize the mets is this:

healthunlocked.com/advanced...

Crabcrushe profile image
Crabcrushe in reply to Tall_Allen

Thanks again for the link; it's easier for me to analog the process as a tree disease over spores/mushrooms, as my recurrence seems "seasonal".

I'm certain you're correct, of coure, and will time the resumption of the leuprolide/enzalutamide (at a minumum). I'll research the optimal time on HT/ADT before RT, unless some with experience contributions that information.

Love this place.

Charlie

Tall_Allen profile image
Tall_Allen in reply to Crabcrushe

It's usually 2 months - the important thing is for the PSA to get as low as it can be on hormone therapy before starting radiation.

Crabcrushe profile image
Crabcrushe in reply to Tall_Allen

Thanks again, Grandfather.

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Crabcrusher

NPfisherman profile image
NPfisherman

Here is some info on CRT--chemo/radiation therapy...

curetoday.com/publications/...

Good luck on your plan....

Fish

Crabcrushe profile image
Crabcrushe in reply to NPfisherman

"Spatial cooperation" is an OUTSTANDING descriptive phrase for that particular facet of attack.

Thanks mucho for the ( now bookmarked) link, bro. Great intel.

Nous Regions

Crabcrusher

Crabcrushe profile image
Crabcrushe

Another pertinent question would be to ask whether anyone has an opinion on administration of dosage that is discontinued early/prescribed at less than MTD. Did they test on HeLa cells? Anybody here try it?

Thanks.

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Crabcrushe profile image
Crabcrushe

Lol Medonc called me in today, approved the plan whole cloth, and scheduled the scans. Praise God...I am tickled.

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