Please shoot holes in this plan.

[Crabcrushe]

Dx Stage 4 Gl 9 bone mets only, PSA 41, 6 cy. docataxel, leuprolide since 10/16, PSA 1.2, doubled in a year, added bicalutamide, doubled in a year, swapped out Casodex for enzalutamide, roughly half way through the Provenge thang.

Plan to pause Lupron/Xtandi for 2 quarters, receive SBRT in Sep, cavitaxel w/carboplatin/resume Lupron/Xtandi in Oct with Avodart.

The rationale is that the stinking crab cells are adding the adaptive gene to their long, chromosomal "tail" (roughly) annually (for me), a met or two springs up each double (detectable mets). I picture the process as a tree with "blight spots" as the mets, which are dormant during most of the treatment phase prior to the cell's adaptation/conversion. So, I'm thinking to use enough Grays to render the met sites and gland peranently dormant, while using max tolerable dosages of the ADT(s) for 9 months only. Then I take a vaycay and repeat the cycle with new ADT' s each time. The breaks give my organs a rest, I can regain top physical conditioning, and the little SOB's will barely have time to add on to their tails when they get waylaid by a new weapon (apalutamide, et al.) each iteration.

Nous Defions

Crabcrusher

[Crabcrushe]

Where's the edit button?

[Hidden in reply to Crabcrushe]

See the 'v' after More? Hit that to edit.

[Crabcrushe in reply to Hidden]

Thanks!

[Crabcrushe]

My intent is to receive feedback in the areas in which I' m ignorant or have little experience by people who got the T shirt. Don't t roll over on me now, m'amigo; gonna present this puppy on 3/18.

Nous Defions

[Tall_Allen]

I'm not sure I understand, but I think it's important that you have maximum hormone therapy starting before and continuing through SBRT. A better way to visualize the mets is this:

healthunlocked.com/advanced...

[Crabcrushe in reply to Tall_Allen]

Thanks again for the link; it's easier for me to analog the process as a tree disease over spores/mushrooms, as my recurrence seems "seasonal".

I'm certain you're correct, of coure, and will time the resumption of the leuprolide/enzalutamide (at a minumum). I'll research the optimal time on HT/ADT before RT, unless some with experience contributions that information.

Love this place.

Charlie

[Tall_Allen in reply to Crabcrushe]

It's usually 2 months - the important thing is for the PSA to get as low as it can be on hormone therapy before starting radiation.

[Crabcrushe in reply to Tall_Allen]

Thanks again, Grandfather.

Nous Defions

Crabcrusher

[NPfisherman]

Here is some info on CRT--chemo/radiation therapy...

curetoday.com/publications/...

Good luck on your plan....

Fish

[Crabcrushe in reply to NPfisherman]

"Spatial cooperation" is an OUTSTANDING descriptive phrase for that particular facet of attack.

Thanks mucho for the ( now bookmarked) link, bro. Great intel.

Nous Regions

Crabcrusher

[Crabcrushe]

Another pertinent question would be to ask whether anyone has an opinion on administration of dosage that is discontinued early/prescribed at less than MTD. Did they test on HeLa cells? Anybody here try it?

Thanks.

Nous Defions

[Crabcrushe]

Lol Medonc called me in today, approved the plan whole cloth, and scheduled the scans. Praise God...I am tickled.

Nous Defions