XTANDI beginning to fail

[zenbee13]

Hello my brothers,

So I am 10 years into my battle and have been so very lucky as compared to many. My cancer was caught early. I have no bone mets, and the few lymph node involvements have not grown for a few years now.

Here's my conundrum: my Gleason is 9. I've had the prostate removed in 2009, 2010 saw 13 weeks of RT, and then nothing until 2012, when PSA rose again, Lupron for 4 years by itself was effective, Then in 2016 Lupron + ADT and prednasone, until late 2018, and now in 3'rd month of Xtandi, however after 2 months of decline the PSA blipped up just a tad.

What I don't know is what are the next steps for a man with essentially no mets if the Xtandi continues to fail. I meet with my Onc on Monday the 18'th and want to have some alternatives to present.

Thanks and peace be our journey!

Bees

[Tall_Allen]

Erleada has recently been approved for non-metastatic castration-resistant PC. Another hormonal agent, durolutamide, will probably also be approved shortly.

[zenbee13 in reply to Tall_Allen]

Tall_Allen,

Thank you Bro. I have it on my list for the Oncologist now

[Bob10 in reply to zenbee13]

Tall when will it be available durolutamide for prostate cancer patients with mets

[Tall_Allen in reply to Bob10]

The test with ADT and docetaxel in men with mCRPC will have results in 2022

[Bob10 in reply to Tall_Allen]

Really that's along time

.

[Tall_Allen in reply to Bob10]

They pick a date when they think half the men will survive until, considering the recruitment lag time.

[zenbee13 in reply to zenbee13]

Guys,

My Onc said that Elaida is just Xtandi repackaged, so to speak, to extend patents for Janssen. Bummer

[Tall_Allen]

"Applications seeking regulatory approval of ERLEADA supported by data from the Phase 3 TITAN study are planned for 2019."

[Bob10]

Can't it be used with zitega also

[zenbee13]

You are a gem among gems my friend! I've added it to my notes to discuss with my OC

Peace,

Bees

[zenbee13 in reply to zenbee13]

HI Guys,

Oncologist said that with the current state of my blood work Indomethacin was a non-starter. Good news, at least I think it's good, is that I've got a bone scan coming up on Thursday. If clean, as all have been so far, I will go off all meds and monitor month to month.

I think we all want to get off these damned drugs. I know the risk, and am comfortable with how we will track this. I'm just so happy to be free for even a month I jumped at the offer.

Peace,

Bees