XTANDI beginning to fail: Hello my... - Advanced Prostate...

Advanced Prostate Cancer
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XTANDI beginning to fail

Hello my brothers,

So I am 10 years into my battle and have been so very lucky as compared to many. My cancer was caught early. I have no bone mets, and the few lymph node involvements have not grown for a few years now.

Here's my conundrum: my Gleason is 9. I've had the prostate removed in 2009, 2010 saw 13 weeks of RT, and then nothing until 2012, when PSA rose again, Lupron for 4 years by itself was effective, Then in 2016 Lupron + ADT and prednasone, until late 2018, and now in 3'rd month of Xtandi, however after 2 months of decline the PSA blipped up just a tad.

What I don't know is what are the next steps for a man with essentially no mets if the Xtandi continues to fail. I meet with my Onc on Monday the 18'th and want to have some alternatives to present.

Thanks and peace be our journey!

Bees

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Erleada has recently been approved for non-metastatic castration-resistant PC. Another hormonal agent, durolutamide, will probably also be approved shortly.

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Seeing that they've unblinded the Titan trial, do you think it may also be approved for metastatic disease soon?

targetedonc.com/news/apalut...

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"Applications seeking regulatory approval of ERLEADA supported by data from the Phase 3 TITAN study are planned for 2019."

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Tall_Allen,

Thank you Bro. I have it on my list for the Oncologist now

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Tall when will it be available durolutamide for prostate cancer patients with mets

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The test with ADT and docetaxel in men with mCRPC will have results in 2022

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Really that's along time

.

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They pick a date when they think half the men will survive until, considering the recruitment lag time.

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Guys,

My Onc said that Elaida is just Xtandi repackaged, so to speak, to extend patents for Janssen. Bummer

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There is a trial ongoing or just beginning on Xtandi plus Indomethacin[An anti-inflammatory used for gout]. We already have anecdotal evidence, of men here using Xtandi, where it was beginning to fail, or PSA was not moving down. One gentleman here got a script from his GP, and in 30 days his PSA that was stuck at 0.3, for a year, after rising from undetectable, and fearing castrate resistance, added the Indomethacin, and became PSA undetectable.

I asked around at my Cancer Center with the Trial Nurse Coordinator, and she confirmed that they were aware, and considering the use of Indomethacin, and other anti-inflammatories, in conjunction with other SOC drugs,like Xtandi. My understanding that the dose is 25 mgs, twice daily. This could be a good alternative for your visit. Go to a search engine. and search Indomethacin and Prostate Cancer, pull the papers on it, and take to your next meeting, on the 18th.

Nalakrats

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Can't it be used with zitega also

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Appears to work with AR blockers, which Xtandi is. Zytiga and Xtandi work thru 2 different pathways. But i have no info if it works with Zytiga, and on second thought it might work with Casodex, or allow Casodex to work again--just theory.

Nalakrats

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Appears to work with Zytiga as well.

ncbi.nlm.nih.gov/m/pubmed/2...

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You are a gem among gems my friend! I've added it to my notes to discuss with my OC

Peace,

Bees

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HI Guys,

Oncologist said that with the current state of my blood work Indomethacin was a non-starter. Good news, at least I think it's good, is that I've got a bone scan coming up on Thursday. If clean, as all have been so far, I will go off all meds and monitor month to month.

I think we all want to get off these damned drugs. I know the risk, and am comfortable with how we will track this. I'm just so happy to be free for even a month I jumped at the offer.

Peace,

Bees

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