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Avodart / Dutasteroid

We had a discussion about Avodart and he said he would consider a prescription if I could show him persuasive studies. The following 5 are the best I could find. Does anyone have a favorite study that helped them convince their MD to prescribe Avodart?
We had a discussion about Avodart and he said he would consider a prescription if I could show him persuasive studies. The following 5 are the best I could find. Does anyone have a favorite study that helped them convince their MD to prescribe Avodart?
Scout4answers profile image
Scout4answers
in Advanced Prostate Cancer

Non - metastatic (per PSMA-PET ) but high risk due to PSA 61 . Am I hastening CRPC with ADT and Zytiga

6 PCa , I stopped Avodart for one month 2 years ago .
6 PCa , I stopped Avodart for one month 2 years ago .
PBnative profile image
PBnative
in Advanced Prostate Cancer

DHT lab report

hence their is no need for Avodart? Component DHT, LC-MS/MS Your Value <2.5 pg/mL Standard Range 106.0 - 719.0 pg/mL http://www.theprostateadvocate.com/pdf/DIHYDROTESTOSTERONE%20DHT%20CONTROVERSY.pdf
hence their is no need for Avodart? Component DHT, LC-MS/MS Your Value <2.5 pg/mL Standard Range 106.0 - 719.0 pg/mL http://www.theprostateadvocate.com/pdf/DIHYDROTESTOSTERONE%20DHT%20CONTROVERSY.pdf
Scout4answers profile image
Scout4answers
in Advanced Prostate Cancer
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Catheter

I know there are oral meds out there such as avodart. Anyways, when I got home after the scope, I was not able to urinate. I rushed myself to ER and they put a catheter. it's discomforting but I'll take it in emptying my bladder. God bless you all. Nick
I know there are oral meds out there such as avodart. Anyways, when I got home after the scope, I was not able to urinate. I rushed myself to ER and they put a catheter. it's discomforting but I'll take it in emptying my bladder. God bless you all. Nick
Nicnatno profile image
Nicnatno
in Advanced Prostate Cancer

High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice

However, from what I know, Avodart will inhibit the final step that results in DHT. How often is Enzalutamide [Xtandi] resistance due to intratumor DHT? I don't know, but Avodart is an inexpensive safety play.
However, from what I know, Avodart will inhibit the final step that results in DHT. How often is Enzalutamide [Xtandi] resistance due to intratumor DHT? I don't know, but Avodart is an inexpensive safety play.
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

After Active Surveillance since 2013, time to explore treatment options

PSA under Avodart had been running around 2.0 since 2014. Had a follow-up biopsy in 2014, 18 core, was negative, but received a severe infection, prostatitis from it. Almost went sepsis, because they had me on CIPRO, and the e-coli infection was resistant to fluoroquinolones.
PSA under Avodart had been running around 2.0 since 2014. Had a follow-up biopsy in 2014, 18 core, was negative, but received a severe infection, prostatitis from it. Almost went sepsis, because they had me on CIPRO, and the e-coli infection was resistant to fluoroquinolones.
Yearofthecow profile image
Yearofthecow
in Prostate Cancer Network

Questions for 2nd Meeting with MO tomorrow about reaction to 2 months on Orgovyx and Zytiga

They said the size of my prostate even after 12 years of Avodart precludes me having brachytherapy. RO and MO said they can treat me with “ curative intent “ as shown in STAMPEDE trial.
They said the size of my prostate even after 12 years of Avodart precludes me having brachytherapy. RO and MO said they can treat me with “ curative intent “ as shown in STAMPEDE trial.
PBnative profile image
PBnative
in Advanced Prostate Cancer

Looking for anyone else with the RAD51B mutation with mets to liver.

PSA before - 4.0 PSA after - 0.3 He has been able to control with Avodart, Casodex and Metformin. 06/27/18 started Lupron when PSA was 1.1 10/16/19 started Xtandi PSA 9.3 6/16/21 Pet CT PSMA mets to liver.
PSA before - 4.0 PSA after - 0.3 He has been able to control with Avodart, Casodex and Metformin. 06/27/18 started Lupron when PSA was 1.1 10/16/19 started Xtandi PSA 9.3 6/16/21 Pet CT PSMA mets to liver.
Dadslove profile image
Dadslove
in Advanced Prostate Cancer

Impact of Dutasteride on PSA Kinetics and Time to Progression in Men with PSA-only Recurrent Prostate Cancer - medRxiv - pre-pub May 5, 2021

I know we have some members who will vouch for the effectiveness of Avodart in managing their own disease state.
I know we have some members who will vouch for the effectiveness of Avodart in managing their own disease state.
cujoe profile image
cujoe
in Fight Prostate Cancer

Darolutamide & Simvastatin?

Another escape pathway is the manufacture of DHT (dihydrotestosterone) via the alternate pathway that does not require testosterone, Avodart will inhibit that.
Another escape pathway is the manufacture of DHT (dihydrotestosterone) via the alternate pathway that does not require testosterone, Avodart will inhibit that.
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

No adverse effect from the covid vaccine to my PSA

FYI, apart from statins, Avodart and a long list of supplements I am not under any treatment.
FYI, apart from statins, Avodart and a long list of supplements I am not under any treatment.
Justfor_ profile image
Justfor_
in Prostate Cancer Network

Side effect comparisons: Adovart vs Lupron

I have not had Avodart but might consider it down the road. My main complaints about Lupron include: decreased metabolism leading to obesity, loss of muscle mass, loss of bone density, fatigue and lethargy.
I have not had Avodart but might consider it down the road. My main complaints about Lupron include: decreased metabolism leading to obesity, loss of muscle mass, loss of bone density, fatigue and lethargy.
ron_bucher profile image
ron_bucher
in Advanced Prostate Cancer

Anyone taking a 5ARI (dutasteride/finasteride) with Abiraterone?

I haven't really seen anything on this since Patrick (pjoshea13) had written about it a few years ago: https://healthunlocked.com/advanced-prostate-cancer/posts/139885449/dutasteride-avodart-abiraterone-zytiga Has anyone discussed it with their docs? I plan to, later this week.
I haven't really seen anything on this since Patrick (pjoshea13) had written about it a few years ago: https://healthunlocked.com/advanced-prostate-cancer/posts/139885449/dutasteride-avodart-abiraterone-zytiga Has anyone discussed it with their docs? I plan to, later this week.
noahware profile image
noahware
in Advanced Prostate Cancer

Eleven Years Updates. Starting EstroGel.

Again slow rise and I off and on used Avodart and Casadox during the last three years. Had two 68 GL PSMA in the last three years which came out negative. Now I am planning to start EstroGel therapy. Had been closely monitoring the progress of some of the esteemed members who are on this group.
Again slow rise and I off and on used Avodart and Casadox during the last three years. Had two 68 GL PSMA in the last three years which came out negative. Now I am planning to start EstroGel therapy. Had been closely monitoring the progress of some of the esteemed members who are on this group.
KSK54 profile image
KSK54
in Advanced Prostate Cancer

PSA

I am Al Mayo from canada .I am 86 years old .I have been fighting with my urologist for the past 17 years not to get a biopsy .My psa last Dec was 52.2 and I still refused a biopsy .I have taken many herbs and they work for awhile then stop.My urologist put me on avodart last Jan and he said that if
I am Al Mayo from canada .I am 86 years old .I have been fighting with my urologist for the past 17 years not to get a biopsy .My psa last Dec was 52.2 and I still refused a biopsy .I have taken many herbs and they work for awhile then stop.My urologist put me on avodart last Jan and he said that if
olddryleaves profile image
olddryleaves
in Prostate Cancer Network

5-alpha reductase inhibitors & the risk of hospitalization for COVID-19

I use Avodart as do some of Ar. Myers ex-patients. "Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI.
I use Avodart as do some of Ar. Myers ex-patients. "Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI.
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

BAT, dutasteride, and my search for truth, Part 1 of 2

George71 in reply to kaptank neither Avodart or finasteride are blocking the cells from getting testosterone -- nor are they blocking you from making testosterone -- they only keep you from converting testosterone to DHT. Kaptank: I don't know the answer and cannot find it in the literature.
George71 in reply to kaptank neither Avodart or finasteride are blocking the cells from getting testosterone -- nor are they blocking you from making testosterone -- they only keep you from converting testosterone to DHT. Kaptank: I don't know the answer and cannot find it in the literature.
cigafred profile image
cigafred
in Advanced Prostate Cancer

5α-Reductase Inhibitors are Associated with Reduced Risk of SARS-COV-2 Infection

[1] Note: 5α-Reductase Inhibitors [5ARIs] - such as Dutasteride [Avodart] - inhibit the conversion of testosterone to dihydrotestosterone [DHT]. "SARS-CoV-2 has a disproportionately severe effect on men, suggesting that the androgen pathway plays a role in the disease.
[1] Note: 5α-Reductase Inhibitors [5ARIs] - such as Dutasteride [Avodart] - inhibit the conversion of testosterone to dihydrotestosterone [DHT]. "SARS-CoV-2 has a disproportionately severe effect on men, suggesting that the androgen pathway plays a role in the disease.
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

Avodart mimicking herbs

I see that a lot of members here are taking Avodart to reduce DHT level (5-alpha-reductase inhibitor) and since it is hard to get this medication without a prescription, I searched for herbal replacement such as: 1) Pumpkin Seed 2) Saw Palmetto 3) Green Tea 4) Giant Dodder 5) Reishi mushroom 6) Fatty
I see that a lot of members here are taking Avodart to reduce DHT level (5-alpha-reductase inhibitor) and since it is hard to get this medication without a prescription, I searched for herbal replacement such as: 1) Pumpkin Seed 2) Saw Palmetto 3) Green Tea 4) Giant Dodder 5) Reishi mushroom 6) Fatty
Ralph1966 profile image
Ralph1966
in Prostate Cancer Network

Need to shrink prosate.

Dr wants me to take avodart to shrink prostate. Don't care for sounds of possible side affects. What are the other and best options? New Dr would prefer it smaller before next biopsy due to very large.
Dr wants me to take avodart to shrink prostate. Don't care for sounds of possible side affects. What are the other and best options? New Dr would prefer it smaller before next biopsy due to very large.
DaveNes profile image
DaveNes
in Prostate Cancer Network
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