Experiences with

Avodart

Anyone doing this and what’s your protocol and how are you doing. Iam going on my third month this Friday. Psa went from 3,5 to .8 in the first mo.

Saw Tanya Dorff in USC and was put on triple hormone therapy with 90 day lupron. and Casodex and Avodart Dorff believed in intermittent therapy and was i was given a holiday from treatment if psa and testosterone were hormone sensitive between 9 months to a year until psa started its climb.

Taking Avodart for ten years and doing many lifestyle changes per Snuffy Meyers kept my PSA low for a decade but when I stopped Avodart for a month 3 years ago PSA began to rise .

Is there any support for taking Avodart with Apalutamide to extend castrate sensitivity? I have been on Lupron/Apalutamide for >2 years now. Are there any studies that suggest Lu177 is effective in a castrate sensitive patient?

We had a discussion about Avodart and he said he would consider a prescription if I could show him persuasive studies. The following 5 are the best I could find. Does anyone have a favorite study that helped them convince their MD to prescribe Avodart?

hence their is no need for Avodart? Component DHT, LC-MS/MS Your Value <2.5 pg/mL Standard Range 106.0 - 719.0 pg/mL http://www.theprostateadvocate.com/pdf/DIHYDROTESTOSTERONE%20DHT%20CONTROVERSY.pdf

However, from what I know, Avodart will inhibit the final step that results in DHT. How often is Enzalutamide [Xtandi] resistance due to intratumor DHT? I don't know, but Avodart is an inexpensive safety play.

6 PCa , I stopped Avodart for one month 2 years ago .

PSA under Avodart had been running around 2.0 since 2014. Had a follow-up biopsy in 2014, 18 core, was negative, but received a severe infection, prostatitis from it. Almost went sepsis, because they had me on CIPRO, and the e-coli infection was resistant to fluoroquinolones.

I know there are oral meds out there such as avodart. Anyways, when I got home after the scope, I was not able to urinate. I rushed myself to ER and they put a catheter. it's discomforting but I'll take it in emptying my bladder. God bless you all. Nick

They said the size of my prostate even after 12 years of Avodart precludes me having brachytherapy. RO and MO said they can treat me with “ curative intent “ as shown in STAMPEDE trial.

Another escape pathway is the manufacture of DHT (dihydrotestosterone) via the alternate pathway that does not require testosterone, Avodart will inhibit that.

PSA before - 4.0 PSA after - 0.3 He has been able to control with Avodart, Casodex and Metformin. 06/27/18 started Lupron when PSA was 1.1 10/16/19 started Xtandi PSA 9.3 6/16/21 Pet CT PSMA mets to liver.

I haven't really seen anything on this since Patrick (pjoshea13) had written about it a few years ago: https://healthunlocked.com/advanced-prostate-cancer/posts/139885449/dutasteride-avodart-abiraterone-zytiga Has anyone discussed it with their docs? I plan to, later this week.

I know we have some members who will vouch for the effectiveness of Avodart in managing their own disease state.

FYI, apart from statins, Avodart and a long list of supplements I am not under any treatment.

[1] Note: 5α-Reductase Inhibitors [5ARIs] - such as Dutasteride [Avodart] - inhibit the conversion of testosterone to dihydrotestosterone [DHT]. "SARS-CoV-2 has a disproportionately severe effect on men, suggesting that the androgen pathway plays a role in the disease.

Dutasteride (Avodart) and finasteride (Proscar) are two types of 5-alpha reductase inhibitors. You’ll generally have to wait three to six months for symptom relief with 5-alpha reductase inhibitors.

Again slow rise and I off and on used Avodart and Casadox during the last three years. Had two 68 GL PSMA in the last three years which came out negative. Now I am planning to start EstroGel therapy. Had been closely monitoring the progress of some of the esteemed members who are on this group.

I have not had Avodart but might consider it down the road. My main complaints about Lupron include: decreased metabolism leading to obesity, loss of muscle mass, loss of bone density, fatigue and lethargy.