CRPC, Testosterone &

[pjoshea13]

New Japanese study.

"... we aimed to reveal the association between pretreatment serum testosterone {T} level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC."

"The present study included Japanese patients with metastatic prostate cancer whose serum testosterone levels during androgen-deprivation therapy were available."

OK, so "pretreatment" T means pre-subsequent treatment.

"Progression-free survival among men with higher serum testosterone level was superior to that among men with lower serum testosterone level when treated with enzalutamide."

whereas:

"progression-free survival and overall survival among men with higher serum testosterone level were significantly inferior to those among men with lower serum testosterone level when treated with docetaxel and cabazitaxel"

Seems logical.

-Patrick

ncbi.nlm.nih.gov/pubmed/304...

Urol Oncol. 2018 Nov 13. pii: S1078-1439(18)30404-6. doi: 10.1016/j.urolonc.2018.10.020. [Epub ahead of print]

Serum testosterone level as possible predictive marker in androgen receptor axis-targeting agents and taxane chemotherapies for castration-resistant prostate cancer.

Shiota M1, Kashiwagi E2, Murakami T2, Takeuchi A2, Imada K2, Inokuchi J2, Tatsugami K2, Eto M2.

Author information

1

Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: [e-mail].

2

Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Abstract

PURPOSE:

Currently, several therapeutic options for castration-resistant prostate cancer (CRPC) are available, for which predictive biomarkers have not been established. Therefore, we aimed to reveal the association between pretreatment serum testosterone level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC.

PATIENTS AND METHODS:

The present study included Japanese patients with metastatic prostate cancer whose serum testosterone levels during androgen-deprivation therapy were available. The antitumor outcomes when treated with enzalutamide, abiraterone, docetaxel, and cabazitaxel with clinicopathological parameters including serum testosterone levels during androgen-deprivation therapy, as well as prognoses including progression-free survival and overall survival, were examined.

RESULTS:

Progression-free survival among men with higher serum testosterone level was superior to that among men with lower serum testosterone level when treated with enzalutamide. On the contrary, progression-free survival and overall survival among men with higher serum testosterone level were significantly inferior to those among men with lower serum testosterone level when treated with docetaxel and cabazitaxel, respectively.

CONCLUSIONS:

The present study indicated distinct prognostic values of serum testosterone level when treated with androgen receptor axis-targeting agent and taxane chemotherapy for CRPC, suggesting that serum testosterone level may be useful predictive biomarker to navigate the appropriate therapy in patients with CRPC.

Copyright © 2018. Published by Elsevier Inc.

KEYWORDS:

Abiraterone; Cabazitaxel; Docetaxel; Enzalutamide; Testosterone

PMID: 30446464 DOI: 10.1016/j.urolonc.2018.10.020

[Fairwind]

There is an experimental treatment, BAT therapy, that treats advanced prostate cancer with massive doses of testosterone while keeping the patients on Lupron...This "shock treatment" , flooding PC cells that have been starved for testosterone and suddenly flooding them with it causes them to self-destruct and in many cases produces a nice remission...