BAT: Bipolar Androgen Therapy: A Para... - Advanced Prostate...

Advanced Prostate Cancer

13,365 members16,302 posts

BAT: Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of CRPC.

pjoshea13 profile image

New Denmeade paper, but free Abstract lacks details.

"Bipolar androgen therapy (BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. Initial studies demonstrated that BAT is safe and produces clinical responses. A trial comparing enzalutamide against BAT is ongoing."

I suppose that I bristle a little when I read "paradoxical" & "supraphysiologic".

It is well-established that ADT causes CRPC. In fact, the price of ADT is accelerated aggressive disease. It is Reasonable to think that restoration of androgen might unsettle CRPC cells & perhaps reverse certain aspects of it.

Many men do not acheive "supraphysiologic" levels of T. Far from it. & it is not necessary, it seems. Is 2,000 ng/dL better than 1,000 ng/dL? I haven't seen the evidence. When androgen receptors are saturated with T, how does extra T act?

-Patrick

ncbi.nlm.nih.gov/pubmed/283...

13 Replies

Since I am on BAT rather that paradoxical I call it counter intuitive. I'm not in a trial, but there is one locally and my doctor also has patients in the trial, but since I had already had both Zytiga and Xtandi, I was not eligible. Before my first treatment my PSA was nearly 5000 and in the last 3 months it has fallen as low as 1670, although it was nearly 3000 last week. More encouraging is the fact that scans last week showed shrinkage in lymph mets, shrinkage and apparent healing in liver mets and no new activity in the bones. I'm having another injection of testosterone tomorrow and continue to monitor PSA and T levels every 2 weeks with the plan to have another injection in early May unless numbers are significantly worse or I begin to have pain or other symptoms.

Sisira profile image
Sisira in reply to Gecrellin

Hope this treatment protocol will work 100% for you and you will emerge victorious and cancer free to encourage all of us in the battle.

Good luck

Sisira

BigRich profile image
BigRich in reply to Gecrellin

How has this treatment been for you, PSA values and testosterone?

Rich

What interested me is how in some guys BAT reversed CRPC

Nalakrats profile image
Nalakrats in reply to gusgold

Where Have You Been? I feel abandoned here in Costa Rica. Did you see Patrick's work on DIM---most of it known to me as Zeligs, sent me via e-mail his research papers, from over the years, But the kicker is the possibility of turning off the AR-V7 gene splice, making Xtandi, and Zytiga useful and viable. I need to communicate with my Geneticist about this--and if she has any awareness. Word has to get out.

Anyway back in the States and home this weekend.

Nalakrats

gusgold profile image
gusgold in reply to Nalakrats

Nal,

the word is slowly getting out..imo the future of BAT lies in turning off AR-V7 so Xtandi and Zytiga work again...also there is research showing BAT can reverse CRPC even when AR-V7 is not a factor and reverse AR mutation that occurs in CRPC

Gus

Nalakrats profile image
Nalakrats in reply to gusgold

And if Patrick's data is correct, we can use DIM now. Patrick has been on it 10 years, but I do not know if he had the bio-active form we both use today. I think you cannot wait to have a T level of 1200, and go to the gym and start lifting 400 lbs--and if you still have sex nerves left, like I do---you probably would make a trip to Costa Rica not for the Fishing--if you know what I mean.

Nalakrats

gusgold profile image
gusgold in reply to Nalakrats

Nal,

when your T reaches 1200 the real problem would be you have to wrestle the gator and flip it over before you know if it is a male or female

Gus

Nalakrats profile image
Nalakrats in reply to gusgold

Can only handle about 390 lbs.---that is it--ADT you know.

Nalakrats

Funny! Thanks for the laugh.

I wonder about the "medical establishment" embracing this treatment option. Mayo, are you onboard with it? I doubt it. Seems like you need to find a maverick doctor to step out side the established guidelines.

take the abstract and the publication to you local library. They can order a copy of the journal article as an interlibrary loan.

Anybody know of any UK based oncologists using BAT?

You may also like...