update : Thank you all for replies. The doc... - Thyroid UK

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update

Calceolaria profile image
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Thank you all for replies. The doc called me to the surgery, checked my heart, showed me my rather reassuring Qrisk algorithm and did not push me to statins like the last one did, (with death threats!).

Script given for propananol as I can’t seem to bring down this pounding heart (he couldn’t pick it up) and sending me for blood tests - TSH alone of course, eGFR with U&E, bone profile, CRP, FBC, ferritin, LFT, I can’t go til Monday morning anyway as it’s too late. I have also my Medichecks waiting to be opened, so I’ll do one Monday, the other Tuesday. I’m on a waiting list for the electrode machine thing.

Crashed out on sofa and woke up feeling grim but somewhat reassured.

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Calceolaria profile image
Calceolaria
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Buddy195 profile image
Buddy195Administrator

Great news Calceolaria 👍

SlowDragon profile image
SlowDragonAdministrator

propranolol will significantly lower uptake and conversion of levothyroxine Ft4 to active hormone

Test before starting ideally

How much propranolol has he prescribed

What vitamin supplements are you taking

A magnesium supplement in afternoon or evening may help (at least 4 hours away from Levo)

How much levothyroxine are you taking

Which brand

Is it always same brand at each prescription

Obsdian profile image
Obsdian in reply toSlowDragon

I use bisoprolol and haven't had a drop in conversion (only before that with a dose increase if levo). Calceolaria, might be worth asking if bisoprolol is an alternative.

Calceolaria profile image
Calceolaria in reply toObsdian

Thanks Obsidian. What a shame doc didnt suggest that as I carefully asked if prop would clash with levo. I honestly can’t be bothered at mo to attempt another foray into GP World.

SlowDragon profile image
SlowDragonAdministrator

Are you still only on 75mcg levothyroxine

And approx how much do you weigh in kilo

Unless extremely petite likely on too low a dose levothyroxine

This can cause palpitations, irregular heart beat or ectopic beats

Calceolaria profile image
Calceolaria in reply toSlowDragon

Not having ectopic beats or palpitations, it’s a strong, heavy pounding., reduced somewhat at present, largely around my back/shoulder blade area.

I’m about 70 kilo, still on 75mcgs and my last Medichecks TSH level, on Jan 8th, was 1.0, range 0.27 - 4.2.

I take 3x spray D/K2 and Your Supplement magnesium glycinate 1 cap, 80mg.

I take 1 Super B Complex, Igennus, stopped Monday, preparing for Medichecks next week. Substituted Jarrow Formula Methyl Folate and sublingual Nature Provides Bioactive B12 drops.

SlowDragon profile image
SlowDragonAdministrator in reply toCalceolaria

Possibly low iron/ferritin, low magnesium and/or low thyroid levels

Calceolaria profile image
Calceolaria in reply toSlowDragon

Thanks

Ferritin in Jan was is 208 ug, range 30-332

Folate 30.5 no range.

I’m feeling a bit steadier now.

kiefer profile image
kiefer in reply toCalceolaria

How's your cortisol level? Elevated cortisol can cause palpitations. Do you have any symptoms related to that, like insomnia, systolic hypertension, abdominal weight gain, bloating, skin fragility, etc.? This was my personal experience. I had heart beats so strong that I would stiffen my neck just to keep my head from rocking forward and backward at night. The adrenal glands (in my case) compensated for the lack of adequate thyroid function (atrophic thyroiditis) and I spent almost 2 years with severe insomnia. The palpitations began to lessen once my thyroid therapy began and included adequate amounts of T3.

How Cortisol Affects Heart Contractility

1. Increases sensitivity to catecholamines (Adrenaline & Noradrenaline)

-Cortisol upregulates beta-adrenergic receptors on heart muscle cells, making the heart more responsive to adrenaline.

-This leads to increased stroke volume (the amount of blood ejected per beat) and a stronger contraction.

2. Enhances Calcium Handling in Heart Cells

-Cortisol modifies calcium channel activity, which is crucial for muscle contraction.

-More calcium availability means stronger contractions even at a normal heart rate.

3. Increases Blood Volume & Blood Pressure

-Cortisol stimulates sodium retention via aldosterone, leading to fluid retention and increased blood volume.

-More blood volume can increase preload (the amount of blood returning to the heart), resulting in a more forceful contraction.

4. Reduces Vasodilation (Increases Peripheral Resistance)

-Higher cortisol levels can lead to vasoconstriction, making the heart work harder to push blood through the circulation.

-This indirectly contributes to stronger beats (bounding pulse) even if heart rate remains normal.

Clinical Signs of Cortisol-Induced Increased Contractility

-Bounding pulse (strong and forceful heartbeat)

-Palpitations with normal or slightly elevated heart rate

-Higher systolic blood pressure due to increased cardiac output

-Increased cardiac workload, potentially leading to left ventricular hypertrophy over time

-Worsening symptoms in hyperadrenergic states (e.g., stress, anxiety, hyperthyroidism)

Dehydration can also cause palpitations.

Calceolaria profile image
Calceolaria in reply tokiefer

Thank you, that’s interesting. I did send for a Medichecks test a few months ago but sent it back as I thought ‘Nah, get over yourself’ but some of the symptoms you describe definitely ring bells.

Calceolaria profile image
Calceolaria

Normal rate.

DippyDame profile image
DippyDame

Your FT3 is possibly too low....the heart needs a lot of T3 to function.

Low cellular T3 is a cause of fatigue....and many other things

Calceolaria profile image
Calceolaria in reply toDippyDame

Thanks Dippy.

My last T3, January 8th was 4.9 pmol range 3.1-6.8

FT4 was 20.3 range 12-22.

This was why I was anticipating my Medichecks next week.

SlowDragon profile image
SlowDragonAdministrator in reply toCalceolaria

FT3 low then

DippyDame profile image
DippyDame in reply toCalceolaria

FT3 4.9 range 3.1-6.8

That's 48.65% through the ref range

We aim to have both Frees roughly approaching 75%

Your FT4 is 83% thro the ref range

High FT4 @ 83% with low FT3 @ 48.65% indicates poor T4 to T3 conversion

When conversion is poor we usually need to introduce some T3

But be aware that prop can reduce conversion

High cholesterol is a symptom of hypothyroidism (usually low FT3) adequately replacing T3 should lower cholesterol....made a big difference to my cholesteril level.

The heart needs a lot of T3.....deficiency can cause cardiac symptoms.....eg pounding heart

I'd suggest they can go racing round the houses looking for answers but until they correct your FT3 level with adequate T3 they will be chasing their tail

Clearly we are all different but it is worth remembering that for good health every cell in the body must be flooded with T3 by way of a constant and adequate supply....that is the first step.

How much thyroid hormone are you now taking?

Oooops.....I see it's 75mcg levo, you don't have much room to raise T4 so I'd be pushing to add a little T3.

I need high dose T3-only to function!

Sadly medics knowledge of thyroid disease is miserably poor as is diagnosis and medication.

I would drop the prop ....it will take a few days to clear from your system

Have a full thyroid test

check to see if conversion has improved without prop

( that is %ages are closer)

Then start to correctly medicate with replacement hormones......post new results for help

I'm not sure your medics know what they are doing other than trying to look as if they are busy doing something!!

Good luck!

Calceolaria profile image
Calceolaria in reply toDippyDame

Thanks, yes, I’ve no intention of starting the prop if ever. Everything has settled quite a bit and I’m just tired out.

SlowDragon profile image
SlowDragonAdministrator in reply toCalceolaria

Free T4 (fT4) 20.3 pmol/L (12 - 22) 83.0%

Free T3 (fT3) 4.9 pmol/L (3.1 - 6.8) 48.6%

Shows poor conversion

How old are you…..pre or post menopause?

Helpful to add age on profile and short summary of thyroid so far

See what next Medichecks results show

Hopefully you are also retesting vitamin levels

as your hypothyroidism is autoimmune are you on strictly gluten free diet and/dairy free diet

If not get coeliac blood test BEFORE trialing gluten free

2-3 months later look at trial on dairy free as well

Calceolaria profile image
Calceolaria in reply toSlowDragon

I’m 77 on Monday.

Yes, I’m also testing vitamins, even tho last Medichecks was January. You advised me to test again in 6/ 8 weeks.

I was tested for coeliac, nothing.

I’m not gluten free, tried it and dairy for quite a few months and it did nothing. Or not noticeably.

I will do a profile - I never thought I’d be on this site as much so didnt bother. Mistake!

My cholesterol isn’t bad. HDL is good.

Calceolaria profile image
Calceolaria

Thank you NL. I’m not going to take it. It would give a very inaccurate reading. I want to know what my thyroid or whatever, is up to and this has been waiting to happen for a while!

arTistapple profile image
arTistapple

When you say it’s pounding, is that in your ears or you just feel it in your chest?

Calceolaria profile image
Calceolaria in reply toarTistapple

Upper chest, round the back between shoulder blades mostly.

arTistapple profile image
arTistapple in reply toCalceolaria

Yes I get it in my ears as well as all the places you mention. I should have asked - any pain accompanying it?

Calceolaria profile image
Calceolaria in reply toarTistapple

Thank you. It has settled into extremely painful shoulder/upper back muscle pain/soreness. I’m wondering about injury but I can’t think what - and why the heart pounding.

arTistapple profile image
arTistapple in reply toCalceolaria

My situation (a very long time since and never properly diagnosed) was I now realise, the first very important symptom of my hypothyroidism. I think it’s probably extremely rare to start with this symptom. “Rare” is always accompanied by a scarcely polite reply from medics, implying to the patient “Liar”. However the upshot/conclusion I have come to is it’s the most important symptom of the state of my hypothyroidism.

I would advise that you examine your dosage and blood tests very carefully. What could be going on? Don’t see any current useful testing in your post.

Unfortunately I have found medics total lack of any respect for the patient gets us nowhere fast. We experience such a rigid culture re: heart, it’s not thoroughly examined.

It’s very likely your Levo is an issue. One way or another. I found 75mcgs a very ‘difficult dose’. I have seen others report this too. I have seen it explained as a sort of transition dose. I think that might be a very important point for quite a few of us. Anyway there does seem to be an issue at this dose. Anyone’s guess why though, as so little research is done on dosing. Each to their own it seems.

Get full blood tests done privately and don’t waste any more time on medics.

Calceolaria profile image
Calceolaria in reply toarTistapple

I’ve had 3-4 private tests over past two and a half years and posted regularly on here. The consensus seems to be poor conversion.

Definitive ( I hope) private fully comprehensive thyroid and vitamin etc test due tomorrow and GP also wants NHS tests tomorrow so it’ll be interesting to compare TSH at the least.

Thanks. I’ll be updating my results on here next week - I really must sort out my profile.

Best wishes.

arTistapple profile image
arTistapple in reply toCalceolaria

Excellent. Will look out for your post.

Poniesrfun profile image
Poniesrfun

Curious if “pounding heart” is all the time or only specific time, such as following meals or anticipating meals. The stomach produces H2 (histamine 2) which the heart is very suspitble to. This is a little different than the histamine that causes allergies, though it can contribute a bit to allergies. I have found taking an H2 blocker. such as famotadine (Pepcid) once in a while “as needed” helps me. Plus it doesn’t mess up your gut like PPI stomach acid meds do.

Patti in AZ

Calceolaria profile image
Calceolaria in reply toPoniesrfun

Food has revived the ghost of it, especially if sweet. I did consume a lot of calories - well, more than usual anyway - yesterday, the day after the episode.

That’s well worth a try. Thanks. I won’t try anything until after my blood tests. I do have Peptac liquid ( like Gaviscon but no aspartame) in the house which I occasionally use as I don’t like the PPI stuff and am aware if it’s negative impact.

Having now looked it up I can see Peptac wouldn’t be useful as a blocker.

How would you know when to take it, as it’s a pre-emptive medicine?

Poniesrfun profile image
Poniesrfun in reply toCalceolaria

I take it if my heart rate goes up a tad, if I have any feeling (even slight) of “pounding”and before heavy meals (my neighbor is a chef who loves having us for holiday and birthday dinners). And, hard to explain, somethimes when I just feel I might need it. 🤗

Calceolaria profile image
Calceolaria in reply toPoniesrfun

Many thanks.

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