Hi all, I just thought I'd give a little update as I've not posted here in about a year and just possibly my experience may be of interest. I am not in ANY way invalidating anyone else's condition or treatment, this is just my story.
For years I have struggled with low mood, lacking 'oomph' in life. I put this down to my irradiated thyroid and supposed suboptimal treatment on Levothyroxine mono. I tried T4+T3 for years into the price hike, then I imported NDT, then imported T3. I tried diet, exercise, ensuring my vitamins were good. All of it.
Last year my final throw of the dice was to start TRT - Testosterone Replacement Therapy. It had zero positive effect but had the side effects of giving me terrible sleep, sweating profusely at night. Blood tests showed T > 100% and oestradiol > 200%. I stopped that.
I've come to realize that my problem is psychological and hence I'm seeing a counsellor. I'm coming to accept and eventually I hope to love myself for the first time. It's gruelling but fruitful so far.
Again, I'm not suggesting this is an answer for anyone else, but it might be an avenue worth exploring once you've explored the medication route?