DIO2 Homozygous CC

[Pearlteapot]

I got the test results from Regenerus today and I am homozygous CC which means 'CC infers a lower than average response and that tri-iodothyroxine (T3) perhaps should be considered'.

I saw my new Endo for the first time very recently (Saturday) and he increased my levo dose from 93mcg to 100mcg, re-test in 6 weeks and speak to him then. I do already feel a bit better or less worse.

I am going on holiday on 11 August for 3 weeks.

I'm thinking that there is no point contacting him about this before I go away as:

(1) its too soon after my recent dose change to consider adding T3 and he won't

(2) It would be stupid to start T3 while I'm on holiday.

So my best bet is to optimise 'everything else' so that I am in good shape to try T3 when I next see him in September. I understand 'everything else' to mean B12, Folate, D3.

Is there anything else?

Iron? I'm having trouble deciding what to do with iron. I posted recently about Iron where I have very low serum iron and also low TIBC

healthunlocked.com/thyroidu...

On that thread radd advised that if I don't supplement iron my ferritin would soon drop. Neither my GP nor my Endo were concerned in the least with my low serum iron. I am still worried that I shouldn;t supplement because the low TIBC suggests I have a lot of iron. So I started Floridix but then stopped it again. Perhaps I should start again, it's only 6 weeks after all.

[SlowDragon Administrator]

radd or humanbean or SeasideSusie might pop along and comment on iron /ferritin

[Musicmonkey]

Unfortunately, increasing your T4 isn't likely to help, although all patients have to be started on T4, which is rather cruel in your case. Your DIO2 polymorphism, particularly as you are homozygous, means you don't convert well. Your body struggles to turn T4 into T3, the active hormone.

I am guessing you have hypothyroid symptoms?

National guidance in England accepts that a sub set of patients need T3 as well as T4 and you fall into this category.

Has the Endocrinologist suggested T3 supplementation might be needed? While waiting for your appointment, I suggest some research on DIO2. If need be, send it to your Endo, so that when you meet with him he will hopefully see the need and agree to get you on to T3.