latest blood results: Hi everyone last year just... - Thyroid UK

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latest blood results

foxyeyes profile image
12 Replies

Hi everyone last year just at the beginning of covid i had an accident and smashed my shoulder it's still not right at first didn't feel too bad but over the last 5 months i have felt rotten no energy, hair falling out, weight gain, got no eyebrows now,dry skin swollen with water retention and worst of all no motivation, shave spoken to GP 4 times but all he says is my last bloods were fine and it takes time to recover then he blames my age so have had bloods done with Blue Horizon here are results

Magnesium H 1.08 o66-099 mmol/L

Cortisol 472 6am -10am 113.456 nmol/L 4pm -8pm 58-278

midnight 64

TSH H 6.12 0.27 -4.20nmol/L

Total T4 126.0 66-181 nmol/L

Free T4 15.7 12.00-22.00 pmol/L

Free T3 4.38 3.1-6.8 pmol/L

Antithyroidperoxdiase abs 13 34 klu/L

Anti Thyroglobulin abs H 117 115 klu/L

i take 100 mcg of thyroxine daily any advice would be welcome

take care and have a good day

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foxyeyes
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12 Replies
tattybogle profile image
tattybogle

TSH 6 would explain how you feel. Contact your Doctor and tell him about this result, if he doesn't feel he can accept a private blood test, then at the very least he should arrange an NHS blood test to check your TSH. if it is that high then you probably need a small dose increase .

make sure the test is early as possible in the morning and take that day's dose afterwards. (that should give highest TSH level, and lowest fT4.)

foxyeyes profile image
foxyeyes in reply to tattybogle

Thanks for replying so quickly he hasn't accepted them in the past but will give it another go

tattybogle profile image
tattybogle in reply to foxyeyes

be firm ...." i have found that my TSH is now over range at 6, and i have symptoms of undermedication so i'd like to try an increased dose of 25mcg (or at least 12.5 mcg) to see if it improves my symptoms. I understand you may not be able to accept a private test result , but if that is the case, please run your own to confirm my current TSH level"

it's not reasonable to say "it was OK last time he looked" as you have given him a good reason for him to look again.

when he said 'your last blood were fine' do you know the actual TSH result ? 'fine' is a matter of opinion "

Ask him what you previous TSH actually was (and range)

Hopefully someone else can comment on the high AM cortisol. as i don't know much abut that ., except it's higher than it should normally be in the morning.

If GP has difficulty accepting your TSH should be kept lower than 6 .. point him to this article in 'GPonline' written by a specialist registrar in endocrinology , and a specialist registrar in cardiology in 2010

healthunlocked.com/thyroidu....

"Replacement therapy with levothyroxine should be initiated in all patients to achieve a TSH level of 0.5-2.0pmol/L. "

foxyeyes profile image
foxyeyes in reply to tattybogle

Sorry for late reply have not been at all well and we are moving house thank you for your reply have spoken to doctor and had new blood tests so will find out this week

tattybogle profile image
tattybogle in reply to foxyeyes

:) apologies not needed .x we know what it's like. ...really glad i'm not moving house .you have my sympathy .

SlowDragon profile image
SlowDragonAdministrator

Do you always get same brand levothyroxine at each prescription

What vitamin supplements are you currently taking, if any

Was test done as early as possible in morning before eating or drinking anything other than water and last dose levothyroxine 24 hours before test

Did you get vitamin D, folate, ferritin and B12 results too?

Request 25mcg dose increase in levothyroxine and bloods retested 6-8 weeks time

TSH should be under 2 as an absolute maximum when on levothyroxine

gponline.com/endocrinology-...

Replacement therapy with levothyroxine should be initiated in all patients to achieve a TSH level of 0.5-2.0pmol/L.

New NHS England Liothyronine guidelines July 2019 clearly state on page 13 that TSH should be between 0.4-1.5 when OPTIMALLY treated with just Levothyroxine

Note that it says test should be in morning BEFORE taking levothyroxine

Also to test vitamin D, folate, B12 and ferritin

sps.nhs.uk/wp-content/uploa...

Aim is to bring a TSH under 2.5

UK guidance suggests aiming for a TSH of 0.5–2.5

gp-update.co.uk/SM4/Mutable...

Dr Toft, past president of the British Thyroid Association and leading endocrinologist, states in Pulse Magazine,

"The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range - 0.2-0.5mU/l.

In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l.

Most patients will feel well in that circumstance.

But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l.

This 'exogenous subclinical hyperthyroidism' is not dangerous as long as serum T3 is unequivocally normal – that is, serum total around T3 1.7nmol/l (reference range 1.0-2.2nmol/l)."

(That’s Ft3 at 58% minimum through range)

You can obtain a copy of the articles from Thyroid UK email print it and highlight question 6 to show your doctor



please email Dionne at

tukadmin@thyroiduk.org

foxyeyes profile image
foxyeyes in reply to SlowDragon

Sorry for late reply have not been well and we are moving house as well i do take the same levothyroxine they have tried to change it but stuck to my guns i take a powder called Green Vibrance it has got all i need,i did the test at 7.am on empty stomach i spoke to my GP and he said to have another blood test will have results this week thank you for your reply

SlowDragon profile image
SlowDragonAdministrator

Also ….approx how much do you weigh in kilo

guidelines on dose levothyroxine by weight

Even if we frequently don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or near full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

Also here

cks.nice.org.uk/topics/hypo...

gp-update.co.uk/Latest-Upda...

Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.

For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.

For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

foxyeyes profile image
foxyeyes in reply to SlowDragon

thank you will look at this

Jazzw profile image
Jazzw

It’s not your age, it’s your doctor.

It’s fairly obvious to me you need an increase in levothyroxine.

Grrr. Some doctors…. :(

SlowDragon profile image
SlowDragonAdministrator

Likely low iron/ferritin when under medicated

Low ferritin leads to hair loss

foxyeyes profile image
foxyeyes in reply to SlowDragon

i have had full blood tests will find out results this week thank you for your reply

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