Urine vs blood for B vitamins - anyone understand why one could be high and one low?

[jsy_girl]

I have had several blood tests for Vitamin B12 which has increased over the past 12-14 months via supplementation (igennus super B mainly). My latest medichecks result was:

31March active B12 204 pmol/L (25.1-165)

I then had a Dutch test which involves both saliva and urine tests. As part of the urine testing they test B12 and B6 markers which it says may be deficient if high. Both were high suggesting deficiency.

Methylmalonate (MMA) Above range, 2.7 ug/mg (0-2.5) (Vitamin B12 marker)

Xanthurenate Above range, 2.82 ug/mg (0.12-1.2) (Vitamin B6 marker)

Kynurenate Above range, 7.1 ug/mg (0.8-4.5) (Vitamin B6 marker)

So after this I decided to get a vitamin B6 blood test from medichecks as I didnt want to supplement B6 if it was also high, and like B12, it was high:

7June B6 29.7 (8.7-27.2) over range

My functional doctor suggested this is a result of insulin resistance, and working on insulin resistance will help. I know insulin resistance relates to sugar but does it also work with letting vitamins in? I have PCOS which is why i have some insulin resistance.

My B12 was low before I started supplementing, but it would seem potentially i'm not actually absorbing it properly. Just wondering now what to do about supplementing? Is it pointless if its not actually going in?

Has anyone come across this before?

[nellie237]

Hi jsy-girl,

Oooh, that's very complicated, and you can't test whether or not your B vits are getting into your cells. Keto diet?

Good luck😊

[helvella Administrator Thyroid UK]

I suggest you ask over on the Pernicious Anaemia Society forum. There are some with good science backgrounds who might well be able to answer properly.

healthunlocked.com/pasoc

[jsy_girl in reply to helvella]

Thank you - good idea