Give up Syntroid. Will try Hydrocortisone. - Thyroid UK

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Give up Syntroid. Will try Hydrocortisone.

Lucas22 profile image
17 Replies

Hello.

After 6 weeks with 112 mcg of Synthroid, I came with the folling results:

TSH: 0.49 Ref: 0.35 – 4,94

Free T3: 2.30 pg/ml Ref: 2 to 4.4 pg/ml

Free T4: 1.09 ng/dl Ref: 0.70 – 1.48

Total T4: 7,65 ug/dl Ref: 4,87 – 11,72

Total T3: 0,71 ng/ml Ref: 0,64 – 1,52

Even whit a low TSH, my thyroid hormones are low in the range.

I still low like a turtle on these dose and can’t tolerate 2.5 mcg of T3.

If I don’t tolerate T3 the problem is either iron or cortisol.

My ferritin is normal, at 150.

I will ask my doctor for a trial of hydrocortisone 2.5 mg capsules, to take 5 mg in the morning and 2.5 mg at evening.

If I fell something it is cortisol that I am missing. If in the first day I fell noting, will stop.

Wil also ask for 0.5 mcg of T3 to see If I can tolerate that dose.

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17 Replies
Xanthi profile image
Xanthi

Could I ask what symptoms your intolerance to t3 were please?

Lucas22 profile image
Lucas22 in reply to Xanthi

More fatigue, brain fog, depression, fast heart rate.

Xanthi profile image
Xanthi in reply to Lucas22

Slightly different to mine, I wondered if it were similar. It made me extremely panicky & wired. Don’t know if due to low cortisol or low ferritin or maybe releasing loads of rt3?

JAmanda profile image
JAmanda

My 'intolerance' to T3 was because I was taking too little. When I stopped cutting the pills into 2.5 or 5 mcg and took 2x10 mcg all in one go, with t4, first thing in the morning I had no intolerance (head ear neck pain) at all.

jostafford0 profile image
jostafford0

Hi Lucas, your situation seems very similar to mine - I can't tolerate T3 or anything combined with T3 either. It makes me feel dreadful. I'm on Levo 112mcg at the mo and I feel alright, not good just alright and still feel really tired in the mornings. My free T3 and free T4 are not great either. I know about the cortisol thing but can you explain about the iron? Thanks so much & best of luck Jo x

Rather than asking your GP for hydrocortisone I would ask him to test to see if you do have low cortisol by doing an early morning blood cortisol. Whereas HC might help you in the short term it won't in the long term as it will stop your adrenal glands working altogether & you will end up needing steroids for life which you really don't want as it is a life threatening condition. I have adrenal insufficiency due to removal of a pituitary tumour, my adrenal glands now don't work so I am dependent on the steroids, if I stop taking them I will die.

Lucas22 profile image
Lucas22 in reply to

Thats the problem. My morning serum cortisol is normal for a 8:00 am test, but my salivary morning cortisol is low.

in reply to Lucas22

Salivary cortisol is not a good way to measure low cortisol, it is only good for testing for high cortisol as in Cushing's syndrome. The serum will be a much more accurate readinf of your cortisol levels.

magsyh profile image
magsyh in reply to

That's rather over the top regarding HC. There is no problem providing you take a low dose. Under 10 mg a dose will not shut down your ACTH. Too low a daily dose will cause adrenaline but around 20mg a day is perfectly safe. I cannot tolerate thyroid medication without it due to low cortisol. All my anxiety has gone and I feel human again. I think it's more dangerous to take thyroid medication without it as it made my cortisol even lower.

in reply to magsyh

I'll have to disagree with you on that, 20mgs is the therapeutic dose for people with adrenal insufficiency , so for someone who's adrenal glands are working ie not proved to be insufficient then by taking HC may tip them into either Cushing's syndrome or adrenal insufficiency. Having had Cushing's disease & now adrenal insufficiency I wouldn't wish them on my worse enemy!

Lucas22 profile image
Lucas22 in reply to

Today I took 3 mcg of T3 twice a day and I am very, very tired, without any energy and my hands are freezing.

Without thyroid medication, my TSH is 6. I am beginning to think that I should try to get a tsh between 1 and 1.5. Staying with low tsh only caused an absurd aging of my skin, my face has aged and my hair has fallen since I started playing with my thyroid. My face looks like it's fallen, it's horrible.

One thing that makes me think that I am taking too much hormone is that without medication my SHBG was normal, and since I started taking T4 my SHBG is super high, above the reference, and if you search now on google what causes an elevation on SHBG you will see that the answer is Hyperthyroidism !!

Xanthi profile image
Xanthi in reply to magsyh

I had a few injections into my feet as I had a lot pain in the joints of my feet through bunions. The third one I had made me a bit dizzy. I remember searching and came across a study that was done with athletes, stating that occasionally just one dose can put someone’s adrenals out of balance and have a lasting affect. So I didn’t have any more. Felt it better to err on the side of caution.

FitnessMike profile image
FitnessMike in reply to

even if the dose is physiologic ???

in reply to FitnessMike

I think you ,may mean physiologic doses? It would only be physiological dose if it was shown that the adrenal glands weren't working as well as they should. If the adrenal glands were functioning properly then it wouldn't be a physiological dose. This article talks about steroids & the side effects of them. ncbi.nlm.nih.gov/pmc/articl...

FitnessMike profile image
FitnessMike in reply to

yes i meant physiological, low cortisol is often cause of not tolerating thyroid med, i can only take fraction of NDT, if i take more it is just stacking in blood and causing high adrenaline and muscle twitches, and blood results are very high in all hormones.

jgelliss profile image
jgelliss

You didn't post your vitamin "D" levels. From my personal experiences in order for me to be able to tolerate T3/NDT I had to add more T4 Iron vitamin "C" B- Complex Celtic Sea Salt for electrolytes /adrenals. I wouldn't worry about TSH . When ever adding T3/NDT it will lower the TSH very low. FT3 and FT4 are the more important thyroid markers. Symptoms are very important markers since every single cell needs thyroids. Journal your symptoms they are very telling . Labs are just a snap shot of the moment you had your labs done.

Lucas22 profile image
Lucas22 in reply to jgelliss

I take 5.000 iu of vitamin D3 and my levels are 70 ng/ml.

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