Thyroid antibodies: If one has 5 to 6 times the... - Thyroid UK

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Thyroid antibodies

Tythrop profile image
16 Replies

If one has 5 to 6 times the "Safe" (35) ati tpo antibody count and had been constantly in the bottom 35% of the tsh "safe" zone, about 5% below T4 zone and about 10%from bottom of T3 "euthyroid" zone, And feeling lots of Hashimoto's symptoms And had been officially medicated in the past for very very high oveeractive(post partum) accompanied with great illness And had a blood family history of Thyroid illness... Would you think it reasonable to prescribe treadment? Any views welcome as I am about to start self medicating with Armour dessicated thyroid and will self moniter with medicheck pin prick blood testing and personal analysis of symptoms (having been very very Hyperthyroidal in the past I think I know what overactive feels like. PS I saw that Thyroid UK did a presentation to a debate at Parliament. Its online.

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16 Replies
Wetsuiter profile image
Wetsuiter

My brain wont quite compute. Would you mind posting your actual results with ranges?

Tythrop profile image
Tythrop in reply to Wetsuiter

Anti peroxidase antibody 500%

T3 : 35%

T4: minus 5%

This is based on saying that the minimum figure in the range was 1% and the max 100%

greygoose profile image
greygoose in reply to Tythrop

Far better to give us the actual numbers, eg:

TSH result (range)

Takes less thinking about!

But, if you have high antibodies (Hashi's), high TSH and under-range FT4, why isn't your doctor treating you?

No idea what you mean by a 'safe zone'. :)

Tythrop profile image
Tythrop in reply to greygoose

Test today shows my TPO antibodies now 94 (ref range :under 35 U/ml is normal, 34 is borderline and above 34 is "TPO positive" ).... So I am well above.

In 2018 I was feeling ill and paid for a private Blue Horrizon blood test which showed about 160 for TPO antibodies but T3T4 were both low but not low enough to trigger the protocol.

All this time I have low but within protocol- range tsh/t4/T3 or sometimes very slightly below range... But medics say no to treatment because of protocol.

Having read Prof Toft and others I suspect that my thyroid is shrunk and pretty ineffective. This would be as a result of consistent exposure to TPO antibodies for over 20 years. The very very high TPO which caused post partum thyroiditis in 1999 successfully treated pre protocol (I was very very ill with Hyperactive thy) followed by years of lower but always above range TPO antibodies.

I think I have low Tsh and low T3 T4 (which shouldn't make sense because when tsh goes down t4/3should be elevated and vice verca) but because the hypothalamus-pituatory-thyroid communication is basically worn out the readings are not protocol compliant... I am not protocol compliant.

I think everyone on this network should keep an eye on their antibody readings.

greygoose profile image
greygoose in reply to Tythrop

Prof Toft also says that if high antibodies are present, you should be treated whether you fit the protocol or not.

Having read Prof Toft and others I suspect that my thyroid is shrunk and pretty ineffective. This would be as a result of consistent exposure to TPO antibodies for over 20 years.

No, it wouldn't. That's not how Hashi's works. The TPO antibodies themselves don't do very much, they're just easy to test for to see if you have Hashi's. But, you can still have Hashi's, even if you never have over-range antibodies, so the antibodies are not the disease. Your thyroid would be shrunken due to continual attacks from the lymphocytes produced by the immune system.

The very very high TPO which caused post partum thyroiditis in 1999 successfully treated pre protocol

TPO antibodies don't cause post partum thyroiditis. You have been misinformed. You already had Hashi's, which is very common post partum. But there is no protocol to treat them. They go up and down by themselves, no matter what you do. But, they don't need treating because they don't do anything much. They are just there because you have Hashi's. And, the nature of Hashi's is to swing between hypo and 'hyper' as the thyroid is slowly destroyed.

But, the upshot is that you do have Hashi's - which can produce some unusual blood test results - but you still haven't given us the actual numbers, meaning that it's difficult for people to advise. :)

Tythrop profile image
Tythrop in reply to greygoose

Thought I had gvn numbrs:

In 2018 when I felt ill so tested by by Blue Horrizon :

Tsh 1.58 (0.27 to 4.2)

T4.63.4.(66-181)

T3.4.09.(3.01-6.8)

Anyi TPO antibodies 166 (RANGE 34 and below)

Ferritin. 67.7.(13-150)

Magnesium 1.01.(0.66-0.99)

Reverse T3. 11.(10-24)

Rrverse T3 ratio. 24.21 (normal equal to or more than 34..so I was "borderline")

Vit D. 51 ( insufficient is between 25-50)

Folate 14. (8.83-60.8)

B12. 157. (insufficient is 145-250)

Feb 2020 blood test by NHS as I feel ill again (actually I feel ill most winters with Hashi symptoms)

Anti to antibodies. 94 (above 33 is positive)

Tsh. 1.67.(0.27-4.2)

Free T4. 12. 2. .(12-22)

B12 503.(107-771)

Tpo antibodies. 94 (above33 is positive)

D3 vitamin 124( above 75 is optimal

greygoose profile image
greygoose in reply to Tythrop

No, you just gave percentages, which isn't all that informative. :)

T4.63.4.(66-181)

That is a TT4, which doesn't give us much in the way of useful information. Can you add the FT4?

T3.4.09.(3.01-6.8)

That is rather low. We would expect a higher TSH with that low FT3, but it depends on the level of the FT4.

Ferritin. 67.7.(13-150)

That's rather low. If you could eat liver once a week, that would probably raise it to a more comfortable level.

Magnesium 1.01.(0.66-0.99)

No point testing serum magnesium, even when good the results don't mean you're not deficient. Best to just take some and see if it helps.

Reverse T3. 11.(10-24)

Rrverse T3 ratio. 24.21 (normal equal to or more than 34..so I was "borderline")

Borderline what? Reverse T3 is totally irrelevant. It doesn't give you any useful information. It's not the 'missing link' that people were led to believe at one point. Really not worth testing.

Vit D. 51 ( insufficient is between 25-50)

At 51 it's still insufficient, so needs supplementing with it's cofactors, vit K2-MK7 and magnesium.

Free T4. 12. 2. .(12-22)

That FT4 is too low. So, even though your TSH is not too high, you really do need to be on thyroid hormone replacement.

When TSH is low and Free T4/3 are also low, one has to suspect a pituitary problem. However, it's very difficult to get doctors to consider it - most of them don't even know that that is possible. I would suggest you direct future research along those lines. :)

Tythrop profile image
Tythrop in reply to greygoose

Ta

Hillwoman profile image
Hillwoman

Do the percentages you've given relate to results within the lower portion of each reference range, or are you talking about percentages below the ranges?

Tythrop profile image
Tythrop in reply to Hillwoman

Confusion is my middle name at ptesent

Anti TPO was 5 times over the limit

For T3 if the lowest figure in the range was 1% and the highest figure in the range was 100% then my reading was 35%. ie 35% up from the bottom/minimum of the range.

T4: if the lowest reading in the range is1% and the highest reading is 100%... mine was minus 5% ie 5% below thr minimum in the range

T3 : if the lowest reading in the range was 1% and highest was 10%, my reading was 35%.

So TPO was +500%.

T4 was +35% and

T3 was - 10%

Hillwoman profile image
Hillwoman in reply to Tythrop

Thanks. I'm quite short of sleep (+brain-fogged), so forgive me for being a bit slow here.

Although it's a good idea to work out how far you are through the FT3 and FT4 ranges, for simplicity's sake the way we usually list results on the forum is to give the actual results in the appropriate units, followed by the lab reference ranges. Then we work out the percentages.

You've described your FT3 as both 35% up the range, and -10% below the range. FT4 at 35% seems too low. Your TPO antibodies reveal Hashimoto's, but you need to know TG abs too. You also need to test B12 (pref 'active'), folate, vit D3 and folate. These are essential nutrients that are often low, both affecting and being affected by hypothyroidism.

I'll ask SeasideSusie and SlowDragon to come in here, because I have no experience of hyperthyroidism and only basic knowledge of it. However, it would seem that you need some thyroid replacment at this stage.

SeasideSusie profile image
SeasideSusieRemembering in reply to Hillwoman

Can't do anything without results and ranges I'm afraid Hillwoman , far too complicated the way the levels have been explained. Not willing to scramble my brain trying to untangle it. I don't think anyone has "got" it from the way it's been explained yet!

SeasideSusie profile image
SeasideSusieRemembering

Why not just give the result and the reference range, then we can all understand. So much easier for everyone who is trying to help you.

Tythrop profile image
Tythrop

Sorry

Hillwoman profile image
Hillwoman in reply to Tythrop

It's okay, we all make mistakes when we're new to the forum. Just have a good read of forum posts so that you can get a feel for the kind of topics that come up regularly, and the way requests for help are normally framed.

Perhaps start a new post?

Tythrop profile image
Tythrop in reply to Hillwoman

Ta

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