Thyroid Disease and MTHFR: How a Gene Mutation Can Affect Thyroid Function
Genes are bundles of information that are passed down through parents to their offspring. Numerous attributes such as eye and hair color, height, and skin tone are determined by our genes. Recent research suggests that genes may even influence the likelihood of developing thyroid issues. Specifically, it is posited that defective methylenetetrahydrofolate (MTHFR) genes may contribute to the occurrence of thyroid disease.
To better understand this connection, we must first discuss the role of MTHFR, the possible complications that come with MTHFR mutation, and the specific effects of irregular MTHFR on thyroid activity.
The Role of MTHFR
The MTHFR gene is responsible for producing an enzyme called methylenetetrahydrofolate reductase. This enzyme has multiple functions such as facilitating the conversion of folic acid, also called folate, into methylfolate.
Methylfolate plays an essential role in the production of neurotransmitters such as serotonin, dopamine, and norepinephrine. Each of these communicative compounds are recognized for their ability to influence mood and regulate a wide range of bodily processes.
Methylfolate is also involved in the creation of s-adenosylmethionine (SAMe), which is used in the regulation of over 200 enzymes throughout the body. The MTHFR enzyme may also be used in conjunction with folate to break down an amino acid named homocysteine to produce methionine. Both methylfolate and methionine are used in a number of important bodily processes.
As a key component for the production of methylfolate and methionine, the MTHFR gene indirectly affects several areas of wellness. These include:
Cell maintenance and repair
Metabolization of chemicals, toxins, B-vitamins, neurotransmitters, and hormones
Production of the body’s main antioxidant, glutathione
Regulation and production of various neurotransmitters
Supporting protein and DNA functionality
Synthesis of CoQ10, creatine, melatonin, carnitine, and phosphatidylcholine; all of which are used in critical bodily processes including immunity and energy regulation
Clearly, by influencing so many essential functions, MTHFR reductase and by extension the MTHFR gene are important factors of wellness. As such, it should not come as a surprise that any sort of mutation or irregularity of the MTHFR gene may result in notable dysfunction...
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