An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression

Not new - from 21013.

The title says it all, really. Full paper readily available from link at end.

One thing that seems to leap out is the vital importance of in-cell conversion.

Front Endocrinol (Lausanne). 2013; 4: 104.

Published online 2013 Aug 22. doi: 10.3389/fendo.2013.00104

PMCID: PMC3749490

An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression

Dario Antonini,1 Annarita Sibilio,2 Monica Dentice,2 and Caterina Missero1,3,*

Author information ► Article notes ► Copyright and


Skin is the largest organ of the human body and plays a key role in protecting the individual from external insults. The barrier function of the skin is performed primarily by the epidermis, a self-renewing stratified squamous epithelium composed of cells that undergo a well-characterized and finely tuned process of terminal differentiation. By binding to their receptors thyroid hormones (TH) regulate epidermal cell proliferation, differentiation, and homeostasis. Thyroid dysfunction has multiple classical manifestations at skin level. Several TH-responsive genes, as well as genes critical for TH metabolism and action, are expressed at epidermal level. The role of TH in skin is still controversial, although it is generally recognized that TH signaling is central for skin physiology and homeostasis. Here we review the data on the epidermis and its function in relation to TH metabolism and regulation of gene expression. An understanding of the cellular and molecular basis of TH action in epidermal cells may lead to the identification of putative therapeutical targets for treatment of skin disorders.

Keywords: thyroid hormones, skin, deiodinase, regulation of gene expression, epidermal development

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18 Replies

  • Saved to read properly when less foggy, thanks helvella :)

  • There is a sonic hedgehog pathway!?! :D

  • Just another day in thyroid paradise; my skin was lovely before Hashi's. Now my face looks like it's been artex'd and the plaster's falling off if I don't slather face cream every blessed night

    Teeny blisters on my hands when I was first diagnosed, soo painful. Little dry patches in random places that never go away, to this day.

    Don't want to think about the doubtless additional effects, had I stayed on levo...

    Thanks x

  • You would never know from looking at your pic ! :-) x

  • Ah, that's my 'before' portrait Marz :D

    I couldn't show you an 'after' as the artist ran away screaming LMAO xx

  • You got Edvard Munch to do it?

  • No - he made a smashing portrait of the artist, running across the Dartford bridge, tho :D

  • Rapunzel

    I have found Cetraban really good for my flaky pie crust skin and everything else I tried added a few fetching boils to the mix 😬 I even put it in my bath, it has sorted out the shin skin - was like peeling bark on an ornamental birch tree. It is worth a try - if doc prescribes it that would save you a few bob if you are in uk and have medical exemption card

  • Thanks for taking the time and sharing. We have two silver birches in the garden so I know exactly what you mean...what a bummer ! I'll get some Cetraben next time I'm in town and give it a whirl; Won't be pleading with my GP despite my exemption card. The less I see of him the better :)

  • Rapunzel

    You should brazen him out and ask for it at £12 a big bottle (I use c 4 or more a year) It soon adds up, and it is a therapeutic treatment we need due to the direct consequences of hypothyroidism ruining our skin we should get it on prescription. I don't see why I should have a peeling face all the time if this gunk can stop it. I didn't ask for this nightmare condition that has finished off a few family members.

    Could you submit a written request for a prescription saying why you want it and mention a friend who has hypothyrodism has a GP who recommended it to her and prescribes it for her (this is true the GP suggested it to me) to great result and see if they just provide one it is hardly a hazardous substance if you can buy it over the counter and really does not need a consultation. You do not need to mention it can be got over the counter of course.

  • Ah me.

    My GP is a tool of the highest order. If I ask for anything, he will have me in his consulting room, curl his lip at my clear weight problem, ask me to get on the scales to which my reply is No thank you, I weigh x kilos and then take my blood pressure. He is a perfect sh*t, I have moved once already and will stay with this buffoon to p*ss him orf.

    That's just the kind of warped b*tch I am and I can live with it. Thankful to be able to lay down my own money, of course - I hear you but with my dunderhead GP, who must be near retirement age ( my big hope ) I may as well talk to the invisible hand in front of his face. One fine day, you misogynist simpleton... :X

  • Rapunzel

    Blimey makes mine look like a saint but I still avoid the surgery like the plague!! You should swap to someone else good for you to refuse the weigh in - darn cheek!

  • The recommended emollient in these cost-cutting times is now Epimax, which is quite a bit cheaper. My GP said that my usual Diprobase was no longer prescribable, so I plucked the name of another product out of the air, but found it unsuitable. I later phoned the surgery's prescriptions office and was told they usually prescribe Zerobase, which is in the same price range as Diprobase!

    As for hazardous: best to keep away from open fires and naked flames.

    Once you're greased up and looking like a Channel swimmer, there's also the problem of ruined bedding and clothes :-(

  • SmallBlueThing

    The cetraban vanishes right into my skin in a nano second and leaves no greasy residue nor does it cause any ruination of clothes, bedding etc. It sounds much better than your stuff (a synthetic version of goose grease? Also sounds like you need the brown paper with it my dad told me about from when he was a boy!) give It a whirl it goes a long way if you are not like Cleopatra here, lobbing it in the bath 🛀🏽 like asses milk 😂😂😂

  • The Channel swimmer bit was an exaggeration (more appropriate to the ointment version), but over time it does stain clothes and bedding. I've just read a discussion about toddlers with eczema leaving greasy marks on carpets, walls and windows.

    Cetraben contains white soft paraffin 13.2%, light liquid paraffin 10.5%; while Diprobase has white soft paraffin 15% and liquid paraffin 6% so I suppose the liquid paraffin makes Cetraben more easily absorbed, while Diprobase is formulated to remain on the surface of the skin for longer.

  • I certainly get no skin reactionsfrom it like other stuff I have tried but not the two you mention.Odd that these minerals should work so well

  • Yes, I've read patients expressing extreme caution about using emollients, as their oils aren't "natural" but, along with many others, I'm forbidden from using products containing lanolin, which is.

  • 21013 - Time travelled over night and it's STILL winter! Lol 😉

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