If this Active B12 result was less than 70, it would suggest testing for B12 deficiency. As it's only 74.6 it's not particularly good. I would want it at least half way through range (112).
She could supplement with a good quality B Complex containing melthylcobalamin (not cyanocobalamin) at a decent level and methylfolate (not folic acid). To start with I'd consider Igennus Super B as at the suggested dose of 2 tablets that gives 900mcg methylcobalamin and 400mcg methylfolate, so both B12 and folate levels should rise. Give it 3 months then retest but leave the supplement off for 7 days before retesting, this is because it contains biotin (B7) and Medichecks have confirmed that their testing equipment uses biotin and will give false results if you don't leave Biotin off for a week before testing.
Once levels are improved, it could be possible to maintain them by just taking 1 tablet per day.
VIT D 33.2 NMOL/L. RANGE 50-175
This is very low and in the Insufficient bracket (below 25 is deficient). It equates to 13.28ng/ml.
The Vit D Council recommends a level of 125nmol/L (50ng/ml) and the Vit D Society recommends a level of 100-150nmol/L (40-60ng/ml). To achieve their recommended level from your wife's current level the Vit D Council suggests supplementing with 4,900iu D3 daily (nearest is 5,000iu).
When the recommended level has been achieved, then she will need a maintenance dose to keep it there, which may be 2000iu daily, maybe more or less, maybe less in summer than winter, it's trial and error so it's recommended to retest once or twice a year to keep within the recommended range. You can do this with a private fingerprick blood spot test with an NHS lab which offers this test to the general public:
An oil based softgel (eg Doctors Best) or oil based liquid (eg Vitabay Organics) or oral spray (eg BetterYou) all give better absorption than tablets or capsules.
there are important cofactors needed when taking D3 as recommended by the Vit D Council -
D3 aids absorption of calcium from food and K2-MK7 directs the calcium to bones and teeth where it is needed and away from arteries and soft tissues where it can be deposited and cause problems such as hardening of the arteries, kidney stones, etc.
D3 and K2 are fat soluble so should be taken with the fattiest meal of the day, D3 four hours away from thyroid meds if taking tablets/capsules/softgels, no necessity if using an oral spray
Magnesium helps D3 to work. We need Magnesium so that the body utilises D3, it's required to convert Vit D into it's active form. So it's important we ensure we take magnesium when supplementing with D3.
Magnesium comes in different forms, check to see which would suit you best and as it's calming it's best taken in the evening, four hours away from thyroid meds if taking tablets/capsules, no necessity if using topical forms of magnesium.
Check out the other cofactors too (some of which can be obtained from food).
TSH 1.98 MLU/L. RANGE 0.27 -4.2
One would expect to see a TSH no more than 2 in a normal healthy person, this is a euthyroid result.
FREE THYROXINE 14.800 PMOL/L RANGE 12-22
One might expect to see FT4 around mid-range in a normal healthy person, this might be a bit low but none of us know where our ideal level is as we're not tested when well for a baseline. This result is classed as euthyroid.
FREE T3 5.43 PMOL/L RANGE 3.1-6.8
A good amount of T3 is being converted from the T4 available and this is a euthyroid result.
THROGLOBULIN ANTIBODIES 77.900 KU/L RANGE <115
THYROID PEROXIDASE ANTIBODIES 14.5 KLU/L RANGE <34
These are both in the negative area, although Thyroglobulin antibodies are rather high. I've checked mine over the years and both TPO and TG have always been less than 10-12. It might be worth keeping an eye on this, retest at some point and see if there's much difference.
MAIN SYMPTOMS ARE
anxiety
depression
loss of hair
extreme tiredness
pains
Symptoms of low nutrient levels can overlap with symptoms of hypothyroidism. You can look up symptoms of low Vit D and B12. I think low Vit D is playing a big part in how she feels:
I would optimise all her nutrient levels, retest in 3-4 months and see how things are then.
Don't start all supplements at the same time. Start with one, leave it 1-2 weeks and if no adverse reaction then add the second one. Continue like this. If she has any reaction then she will know what caused it.
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