Under active gone from too little to too much thyroxine ?

[SherryAMum]

i have paid privately through Thriva for a full thyroid over view

I think my GP has increased my thyroxine too high I am now on 250 a day but still very tired and achy and gaining weight

I also started taking Vit D and B12 3 months ago although i am surprised my results were not better

Based on my news results would you advise any changes ?

Blood test results

Active B12

84.4

Ferritin

84.5

Folate

5.5

TSH

0.075

FT4

23.7

Anti-Thyroidperoxidase antibodies

32.8

FT3

5.05

Thyroxine T4

133.0

TGAB

81.0

Vit d

60.6

[Scazzoh]

Hi Sherry, could you let us have the ranges, which are the numbers in brackets after the results? Ranges change depending on where you live and without them the numbers don't make much sense.

[SherryAMum in reply to Scazzoh]

Active B12

84.4 pmol/L

(25.1 - 165)

Ferritin

84.5 ug/L

13 - 150

Folate

5.5 nmol/L

8.83 - 60.8

Thyroid Stimulating Hormone (TSH)

0.075 mIU/L

0.27 - 4.3

Free Thyroxine (FT4)

23.7 pmol/L

12 - 23

Anti-Thyroidperoxidase antibodies

32.8 kIU/L

0 - 34

Triiodothyronine (FT3)

5.05 pmol/L

3.1 - 6.8

Thyroxine (T4)

133.0 nmol/L

66 - 181

Anti-Thyroglobulin antibodies (TGAB)

81.0 kU/L

0 - 115

25-hydroxy Vitamin D

60.6 nmol/L

50 - 200

[shaws]

I am assuming your test and results above were taken 6 weeks after your new dose.

250mcg of levo used to be a common dose but if you feel your heart is racing and temp high it would be too much.

Going by your blood tests TSH and FT4 (slightly over) and FT3 are good.

If you are still symptomatic I'd ask for some T3 to be added to a reduced T4. Some people only improve on a combination of T3/T4.

Others will respond about your other results

[Hidden]

Your folate (folic acid) levels are below the reference range, if I am reading that correctly. Folic acid deficiency can cause its own symptoms and is needed by the body to make healthy red blood cells. Your body does not store much folic acid so you need to eat a fresh supply everyday, or perhaps supplement until levels return to normal.

[SilverAvocado]

Your freeT4 is over range, and freeT3 about halfway up the range, so you have quite a whopping conversion problem. Really you need to cut that Levothyroxibe slightly and add in some T3, but that is being cracked down on at the moment so you may struggle to get it

The vitamin situation looks pretty bad. B12 and Vit A are both still low, and so is folate. This is good news in a way, because it means you will get some improvement if you can get those up, and it may improve your conversion, too.

How have you been supplementing those two? Have you been using advice from the forum, or going for possibly lower quality treatment? Do you have blood tests from before supplementing, and do you see any improvement?

Generally, if you've supplemented and it hasn't helped, the next step is to ramp up the supplements. Go for the more easily absorbed formulation, or an increased dose. For B12 there are many formats. Hopefully you've had methylcobalamin dissolved under the tongue, and a good B complex with it. For vit D you need a higher dose than GPs will recommend. Probably starting with a loading dose of 5000 or 6000 international units for a month or two.

Hopefully you will get someone more expert to comment on the details of this, and the folate.