Sorry - but this appears to be the same poorly conducted "research" we have seen so often. Just 180 patients. What was the definiton of "restoration of euthyroidism"? Is it really feasible that TSH, FT4 and FT3 were all "restored" every day of the week? Or can we assume that the results were within range for at least one day a week?
Lack of access to the full paper forces me to make assumptions.
Can it be remotely acceptable to proclaim weekly dosing as a proved "valid therapeutic option and can also be considered as a first line therapy," and then comment that they still need to do work on cardiac safety because of risk of sudden cardiac death?
Significant differences were also reported for LDL and triglyceride levels among groups 2 and 3. However, the authors added that some literature has linked higher FT4 levels with increased risk of sudden cardiac death, and recommend future studies on one-weekly dosing measure cardiac safety.
Why on earth did anyone see fit to throw in an anti-T3 comment? (I cannot see this as anything but that.) What "method of absorption" is so very different between T3 and T4? Both get absorbed in our gut in the few hours after ingestion. What is this "Cytomel or T3"? Doesn't the buffoon know that one is a brand name the other a generic approved name?
"If we did the same experiment with Cytomel [liothyronine sodium], or T3, it would be very dangerous," added S. Sethu Reddy, MD, chair of the AACE annual program committee and the moderator of the oral session, highlighting that the method of absorption of this treatment was vital.
I am absolutely NOT convinced of the safety or efficacy of weekly dosing of thyroid hormones.
[ Edited to add this:
The page contains this "disclaimer" - Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. Which, as so often, will likely be behind a paywall so people like us will not have ready access. ]
[ Edited to add this:
Most patients normalized thyroid function with 12 weeks of higher dose
Sorry folks - but dosing with thyroid hormone does not and NEVER CAN normalize thyroid function. At best it can approximately normalize thyroid hormone levels. It doesn't magically make the flaming thyroid work again, does it! ]