NDT trial one or two doses in a day?

Can those of you on NDT give me advice please? How do you find a split dose rather than the full amount in one go? I understand that the problem with two goes in a day can be food/supplement times but I am also unsure of the reasoning behind it. Is it due to the T3 content that I will not have had before? I am currently on 100mg of levothroxin. Second question: I am on antibiotics for the next week. Will that interfere with my NDT? Should I wait to finish the course before starting NDT or will it not matter - this has been a two week course for a gut bug.

12 Replies


T3 peaks in the blood after ingestion and has a relatively short half life so splitting dose x 2 or 3 evens the peaks and avoids the feeling of T3 wearing off.

I would wait a week or two after stopping antibiotics before switching to NDT or you will be unsure whether any adverse effect is due to your illness, antibiotics or NDT.

Thanks clutter.

Hi it depends on the brand . I'm on wp thyroid & always used to split doses until I found on the directions it said one morning dose is recommended .

That is also what I have so was interested to hear other peoples experience. Have you always had WP thyroid - are the directions different on other brands? Just curious.

I have only ever taken wp so couldn't comment on others !

Hi AmandaQ,

I am also taking W.P. Thyroid and have been splitting the dose, taking it twice a day. I have also recently found the directions saying to take the full dose in the morning but I have not tried it yet. I was thinking taking the full amount may give too much T3 in one go.

Have you felt any difference since taking it all in one go.

To be honest I have not found a great deal of improvement over levo. and now wonder if it is because of splitting the dose.

I have not felt any difference to be honest and because it's recommended on the leaflet thought I'd better follow their advice !

O.K. thanks for letting me know.

One benefit too I've noticed is better sleep - not sure if it's connected with the swap but could well be...

Thank you, I may give it a try.

How much do you take?

I take one 2 grain tablet first thing . ranges come back pretty stable in every blood test so far .

That is good news as this is one of my main problems. Thanks AmandaQ

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