I hope someone can help me. I have been Hypo for 10 years now and my meds have been increased over the years to now 300mcgs a day. I am not absorbing the Levothyroxine and after explaining to my GP that I am taking it an hour before food he has spoken to the Endo at the hospital. They have told him to advise me to take all my Levothyroxine on one day of the week which adds up to 2100mcgs!! I am terrified of taking this amount in one hit as I'm worried what t will do to my heart. The GP says it OK, but I'm just to scared to do it. I have lost faith in my GP/Endo as they won't even consider an alternative medication like NDT despite the obvious issues absorbing the Levothyroxine. Has anyone else experienced this?