Please review tests .

[purplemummy]

Hi Everyone ,

See History below . NB I have not started any Thyroid meds as yet as Endo & I wanted to treat Adrenals first ( Hydrocortisone ) Started in September 2015.

I have the following Polyglandular Autoimmune Syndrome ( likely type two ) Which so far comprises of Addison's Disease - Primary , Pernicious Anaemia , Hashimoto's (as yet untreated ), Vitiligo , Anaemia & have had low vitamin D ( Although that I treat & is currently running at 80 ) ,Likely coeliac Disease ( don't eat any gluten ) . My two boys have Polyglandular Autoimmune Syndrome type Two .They have all of above plus Type One Diabetes. It is assumed that I have the same .

Other symptoms which I had put down as Addison's related are thus far Headaches , exhaustion ( although I care 24 hours a day for my boys & have 4- 5 broken sleep every night ) , brain fog & rubbish memory., loss of outer third of eyebrows , hair loss , tricky to lose weight ( could do with loosing around 14 lb ), New symptoms are numb lips . Plus last week tingling hands moving up arms & same with legs ( Tested for Hypoparathroidism - but seemed not that ) . Tingling now passed . I felt dreadful at the time.

I have diagnosed all conditions for all of us . Doctors finally catch up with my diagnosis although often some time later .

I take Hydrocortisone 25 mg spilt over 4 doses plus Fludrocortisone ( one tablet divided into two doses 12 hours apart . Self inject B12 monthly . Don't drink or smoke , eat healthy.

Please could you review blood tests - (9am fasting) I am not keen on standard thyroid treatment - but may need to do that first & then swap to natural . I own a number of thyroid books but am need of some guidance before seeing Endo .

TPO Antibodies 608 kU/L range 0.0 - 9.0 …. YES you do read that correctly top of the range is 9.0 I am 608 !

TSH 4.63 mlU/L ( 0.34 -5.6 )

Free T4 10.20 pmo/L ( 7.5 - 21.1)

FT3 6.90 pmol/L ( 3.8 - 6.8 )

Ferritin 12 ug/L ( 11.0 -336.0)

Folate 24.4ug/L ( 3.1 - 19.9 )

Have other stuff bone profile , red blood cell etc if required

[Clutter]

Purplemummy, TPO antibodies are positive for autoimmune thyroid disease (Hashimoto's) which causes 90% of hypothyroidism.

thyroiduk.org.uk/tuk/about_...

FT3 is mildly over range (transient thyrotoxicosis) which may be due to a Hashi flare up whereby lymphocytes infiltrating the thyroid cause cell destruction which dump thyroid hormone as they die. After a few attacks the loss of cells atrophies the thyroid gland reducing production of thyroid hormones and hypothyroidism ensues.

NHS doesn't usually prescribe Levothyroxine until TSH is over range or FT4 below range. It's unlikely you will be prescribed Levothyroxine while your FT3 remains high as replacement may cause T3 to rise which will make you hyperthyroid. As your FT3 drops your TSH will rise.

Ferritin is almost deficient, optimal is >100 through to half way in range. Supplement iron and take each tablet with 500mg-1,000mg vitamin C to aid absorption and minimise constipation.

Elevated folate is fine as long as B12 is within normal range.

Numb lips and fingers/toes are often due to low calcium. Numbness and tingling in arms and legs may be due to low B12.

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I am not a medical professional and this information is not intended to be a substitute for medical guidance from your own doctor. Please check with your personal physician before applying any of these suggestions.

[purplemummy in reply to Clutter]

Hi ,

Update Endo prescribed 50mg of Levo for two weeks then 100mg from them on .

I really want natural thyroid meds long term .

I know in the US they treat TSH over 2.0 .

So do you think this will now go badly wrong due to T3 being weird ?

I will try again to get iron up . Whatever I take never makes a difference . At one point I was taking 600mg per day of iron with vitamin C

More recently 6 sachets per day of Spa tone per day for 12 weeks with Vit C .

Barely any movement at all .

B12 I self inject monthly .

I also thought low calcium but seemed to be ok plus had Parathyroid Hormone checked .

Thank you for your advice .

[Clutter in reply to purplemummy]

Purplemummy, It's unusual to have high TSH and high FT3 so it's possible you may feel overmedicated if FT3 goes higher.

NDT is not licensed for use in the UK so is rarely prescribed on NHS. Most members using NDT have private prescriptions or buy it online and self medicate.

_____________________________________________________________________

I am not a medical professional and this information is not intended to be a substitute for medical guidance from your own doctor. Please check with your personal physician before applying any of these suggestions.