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Colchicine and Inflammation Revisited
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Advanced Prostate Cancer
11 months ago
Colchicine and Inflammation Reconsidered
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Fight Prostate Cancer
11 months ago
swollen hands 8 weeks after total Hysterectomy?
hi, just wondering if anyone experienced the same ?if so is there anything can be done or taken ? Iam 8 weeks in recovery from extensive surgery , in surgical menopause now as everything was removed .Never in my life had swollen fingers / hands but I can’t wear my rings on either hands anymore ,I haven
hi, just wondering if anyone experienced the same ?if so is there anything can be done or taken ? Iam 8 weeks in recovery from extensive surgery , in surgical menopause now as everything was removed .Never in my life had swollen fingers / hands but I can’t wear my rings on either hands anymore ,I haven
K2023
in
Endometriosis UK
11 months ago
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Medichecks vs. NHS Results
Hi all. I'm wondering whether FlipperTD or indeed anyone else with some technical know-how, can make sense of my blood results. I've recently gained access to my GP records and can see that I've had low ferritin for at least 4 years. Levels have ranged from 17ng/L to 27ng/L on a range of (10
Hi all. I'm wondering whether FlipperTD or indeed anyone else with some technical know-how, can make sense of my blood results. I've recently gained access to my GP records and can see that I've had low ferritin for at least 4 years. Levels have ranged from 17ng/L to 27ng/L on a range of (10
KBird01
in
Pernicious Anaemia Society
20 days ago
Still tired
5/30/2024 Iron: Normal range: 50 - 212 mcg/dL 101 TIBC: Normal range: 228 - 428 mcg/dL 314 % Percent Saturation: Normal range: 20 - 50 % 32 Ferritin: Normal range: 35 - 463 ng/mL Feb 2023 144 May 2024 151 B12: Normal, if on the low side, range: 232-946 356 Vitamin D, pill
5/30/2024 Iron: Normal range: 50 - 212 mcg/dL 101 TIBC: Normal range: 228 - 428 mcg/dL 314 % Percent Saturation: Normal range: 20 - 50 % 32 Ferritin: Normal range: 35 - 463 ng/mL Feb 2023 144 May 2024 151 B12: Normal, if on the low side, range: 232-946 356 Vitamin D, pill
djrpdx
in
Pernicious Anaemia Society
1 month ago
Iron & PLMD
I had an iron panel done a while back, is there any explanation or link to PLMD & the transferrin % being so high? My ferritin test from about a month ago was 200ug/l & had previously been about 250ug/l. I did start regular b12 jabs around the time of the 250 test,so that might account for the ferritin
I had an iron panel done a while back, is there any explanation or link to PLMD & the transferrin % being so high? My ferritin test from about a month ago was 200ug/l & had previously been about 250ug/l. I did start regular b12 jabs around the time of the 250 test,so that might account for the ferritin
drover123
in
Restless Legs Syndrome
1 month ago
Results and Advice Please
Hi There All, Seeking some expertise please. These are my latest test results taken via Medichecks (finger prick) February 19th; TSH 0.013 mIU/L (0.27 - 4.2) -6.5% Free T4 (fT4) 5.9 pmol/L (12 - 22) -61.0% Free T3 (fT3) 5.7 pmol/L (3.1 - 6.8) 70.3% T4:T3 Ratio 1.035 Thyroglobulin Antibodies (
Hi There All, Seeking some expertise please. These are my latest test results taken via Medichecks (finger prick) February 19th; TSH 0.013 mIU/L (0.27 - 4.2) -6.5% Free T4 (fT4) 5.9 pmol/L (12 - 22) -61.0% Free T3 (fT3) 5.7 pmol/L (3.1 - 6.8) 70.3% T4:T3 Ratio 1.035 Thyroglobulin Antibodies (
CDN_Lady
in
Thyroid UK
4 months ago
Cause of RLS - another step
Brain Iron Dysregulation in Iron Deficiency Anemia-Related Restless Leg Syndrome Revealed by Neuron-Derived Extracellular Vesicles: A Case–Control Study Apostolos Manolopoulos, MD ,1 William York, BS,1 Krishna Ananthu Pucha, BS,1 Christopher J. Earley, MBBCh, PhD,2 and Dimitrios Kapogiannis, MD1
Brain Iron Dysregulation in Iron Deficiency Anemia-Related Restless Leg Syndrome Revealed by Neuron-Derived Extracellular Vesicles: A Case–Control Study Apostolos Manolopoulos, MD ,1 William York, BS,1 Krishna Ananthu Pucha, BS,1 Christopher J. Earley, MBBCh, PhD,2 and Dimitrios Kapogiannis, MD1
RLSLearner
in
Restless Legs Syndrome
2 months ago
Albumin
New paper below [1]. About 18 years ago, a man who headed a PCa group in CA told me to forget PCa-related markers - the best indicator that a man wouldn't be around in 6 months was albumin. My albumin had been 3.9 at diagnosis. I worked to reduce sub-clinical inflammation via polyphenols (inhibitors
New paper below [1]. About 18 years ago, a man who headed a PCa group in CA told me to forget PCa-related markers - the best indicator that a man wouldn't be around in 6 months was albumin. My albumin had been 3.9 at diagnosis. I worked to reduce sub-clinical inflammation via polyphenols (inhibitors
pca2004
in
Fight Prostate Cancer
1 year ago
Unexpected visit to A&E
Have angina and as some of you might have read on here took part in ORBITA. 2 trial at Basildon cardiothoratic centre late 2022.. Was given a stent to completely blocked LAD and have been mostly angina free since. Fast forward to this week 3 1/2 weeks post total knee replacement and have had niggling
Have angina and as some of you might have read on here took part in ORBITA. 2 trial at Basildon cardiothoratic centre late 2022.. Was given a stent to completely blocked LAD and have been mostly angina free since. Fast forward to this week 3 1/2 weeks post total knee replacement and have had niggling
annpavitt250448
in
British Heart Foundation
3 months ago
The CRP:Albumin ratio & CRPC Survival
New paper from Portugal below [1]. Here is another study showing the consequences of subclinical inflammation. The inflammation markers used were C-reactive protein [CRP] & albumin. {The useful Modified Glasgow Prognostic Score uses the same markers, but in a cruder way.} It is always better
New paper from Portugal below [1]. Here is another study showing the consequences of subclinical inflammation. The inflammation markers used were C-reactive protein [CRP] & albumin. {The useful Modified Glasgow Prognostic Score uses the same markers, but in a cruder way.} It is always better
pca2004
in
Fight Prostate Cancer
1 year ago
Why is iron over-range yet TIBC shows a need ro take more please?
I'm wondering if the following could be explained please?In past ferritin has been 48 ug/L & obv considered normal by Dr. On doing private iron profile results like the following have come up,on more than one occasion. Iron 24.19 (6,6,-22) Tibc 115.49 (41-77) Transferrin saturation 20.95% (20-55) Kind
I'm wondering if the following could be explained please?In past ferritin has been 48 ug/L & obv considered normal by Dr. On doing private iron profile results like the following have come up,on more than one occasion. Iron 24.19 (6,6,-22) Tibc 115.49 (41-77) Transferrin saturation 20.95% (20-55) Kind
Jo5454
in
Pernicious Anaemia Society
3 months ago
What questions did you wish you’d asked before hysterectomy?
Hi All, I had excision surgery (BSGE surgeon) last autumn (pouch of Douglas, uterosacral ligament and uterine wall) and since spring this year the pain has returned. I’d been offered Zoladex or a hysterectomy, but i pushed for an MRI before making any decisions (the surgeon put me on the waiting list
Hi All, I had excision surgery (BSGE surgeon) last autumn (pouch of Douglas, uterosacral ligament and uterine wall) and since spring this year the pain has returned. I’d been offered Zoladex or a hysterectomy, but i pushed for an MRI before making any decisions (the surgeon put me on the waiting list
Saffie123
in
Endometriosis UK
1 year ago
Three Arrows Iron Repair has arrived! :-)
Last iron results from 1 month ago were: Iron 10.9 umol/L (Range: 10 - 30) TIBC 56.5 umol/L (Range: 45 - 81) UIBC 45.6 umol/L (Range: 13 - 56) Transferrin Saturation X 19.3 % (Range: 25 - 45) Ferritin X 14.90 ug/L (Range: 30 - 207) I have only been taking Spatone drinks since then as iron supplement
Last iron results from 1 month ago were: Iron 10.9 umol/L (Range: 10 - 30) TIBC 56.5 umol/L (Range: 45 - 81) UIBC 45.6 umol/L (Range: 13 - 56) Transferrin Saturation X 19.3 % (Range: 25 - 45) Ferritin X 14.90 ug/L (Range: 30 - 207) I have only been taking Spatone drinks since then as iron supplement
jenny876
in
Thyroid UK
3 months ago
Keeping Going (part 4)
Well having been turned inside out by a nasty Bug and losing 14 lb of weight in two week, my Grandson and daughter convinced me that if at 76 to recover, I was going to have to do a lot of work. So ordered some Whey protein and some weights. So some gentle weight training plus gentle runs. After two
Well having been turned inside out by a nasty Bug and losing 14 lb of weight in two week, my Grandson and daughter convinced me that if at 76 to recover, I was going to have to do a lot of work. So ordered some Whey protein and some weights. So some gentle weight training plus gentle runs. After two
hamit
Graduate
in
Couch to 5K
1 year ago
Iron test results - 6 weeks pregnant
Hello again My last iron test results suggested I was oversupplementing, so I reduced it to 1 Thorne Iron, alternate days. I have since found out I'm pregnant, but not sure that it makes any difference to what I'm doing...guess it will just need monitoring as we go, as iron is one of the things that
Hello again My last iron test results suggested I was oversupplementing, so I reduced it to 1 Thorne Iron, alternate days. I have since found out I'm pregnant, but not sure that it makes any difference to what I'm doing...guess it will just need monitoring as we go, as iron is one of the things that
Molly161018
in
Thyroid UK
3 months ago
update on blood results
Good morning everyone - so referring back to last weeks post my blood tests came back showing raised Neutrophil count 10.2 and my C-reactive protein up at 12 - so GP suggested going back to 12mg for 2 weeks then dropping to 11 for a further 2 weeks then repeating bloods. I also asked for a referral
Good morning everyone - so referring back to last weeks post my blood tests came back showing raised Neutrophil count 10.2 and my C-reactive protein up at 12 - so GP suggested going back to 12mg for 2 weeks then dropping to 11 for a further 2 weeks then repeating bloods. I also asked for a referral
Sungolfer
in
PMRGCAuk
7 months ago
Does this sound like osteoarthritis - or something else?
Hi everyone, I wonder if I can please get some help. I’ve been experiencing widespread body pain for c.3 years. I initially put this down to the menopause and earlier this year I started to focus on my under active thyroid - I’m not yet optimally medicated for that (takes a while). In May I decided
Hi everyone, I wonder if I can please get some help. I’ve been experiencing widespread body pain for c.3 years. I initially put this down to the menopause and earlier this year I started to focus on my under active thyroid - I’m not yet optimally medicated for that (takes a while). In May I decided
J972
in
NRAS
7 months ago
Goat whey, casein, IGF-1 etc. - Do they promote or slow cancer growth?
I've been trying for many years to decide whether to take a protein powder supplement to help maintain muscle mass. Since I started on ADT in 2016, I've lost 30 pounds. I don't know how much is due to the ADT, and how much is due to my diet. I'm 172 pounds now. I was muscular and athletic at 202,
I've been trying for many years to decide whether to take a protein powder supplement to help maintain muscle mass. Since I started on ADT in 2016, I've lost 30 pounds. I don't know how much is due to the ADT, and how much is due to my diet. I'm 172 pounds now. I was muscular and athletic at 202,
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
GNRH Injections and Fibroids
Dear all, I have had painful periods since the age of 12 and I am now 53 years old and they are getting worse. The pain each month is unbearable and I have to take a combination of paracetamol and ibuprofen daily to take the edge off the pain. I had a long period of reduced pain because I went
Dear all, I have had painful periods since the age of 12 and I am now 53 years old and they are getting worse. The pain each month is unbearable and I have to take a combination of paracetamol and ibuprofen daily to take the edge off the pain. I had a long period of reduced pain because I went
Melons70
in
Pelvic Pain Support Network
1 year ago
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